Columbus, OH, United States
Columbus, OH, United States

Franklin University is a private university in Ohio. It was founded in 1902 to serve the needs of adult students. The university has five campuses in Ohio and Indiana as well as large selection of online courses. Wikipedia.

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News Article | February 28, 2017
Site:, a leading career and education website focused on graduate programs in accounting and finance, has released its ranking of the Top Online Master’s in Accounting Programs. To be considered for the list, schools with an online master’s in accounting program were checked for not-for-profit status and accreditation from one of the six regional accreditation agencies in the US recognized by the US Department of Education. The online degrees from the schools on the list are also the same degrees granted to traditional, on-campus students. The rankings were based on factors measuring academic quality, student experience, and graduate success. The ranking uses a unique methodology that considers such factors as the average tuition cost per online credit hour; program accreditation by the AACSB, ACBSP, or IACBE; the average mid-career pay of alumni; and school rankings according to US News & World Report in the regional, national, and online categories. Rob Voce, founder of, said about the list: “Enrollment in online degree programs is increasing and schools are responding by offering more distance education programs at the graduate level - which can be particularly convenient for those who are already working full-time. Our ranking is designed to help these prospective students learn about and compare first-rate online master’s in accounting programs that offer long-term value.” Overall, 37 schools with online master’s in accounting programs satisfied the inclusion requirements and ranked on this list. Auburn University, in Auburn, Alabama, captured the top spot on the list, followed by the University of North Carolina at Chapel Hill in the second spot. As well as providing schools’ results on ranking factors, the Top Online Master’s in Accounting Programs list includes detailed information on schools’ admissions statistics and requirements as well as tuition comparisons. For the top-ranking schools the list also provides: The top schools on this year’s list are: 1. Auburn University Raymond J. Harbert College of Business (Auburn, AL) 2. University of North Carolina Kenan-Flagler Business School (Chapel Hill, NC) 3. University of Connecticut School of Business (Storrs, CT) 4. University of Massachusetts Amherst Isenberg School of Management (Amherst, MA) 5. Pennsylvania State University World Campus (State College, PA) 6. University of Southern California Marshall School of Business (Los Angeles, CA) 7. Emporia State University School of Business (Emporia, KS) 8. Rutgers, The State University of New Jersey Business School (New Brunswick, NJ) 9. Colorado State University College of Business (Fort Collins, CO) 10. University of Alabama at Birmingham Collat School of Business (Birmingham, AL) 11. University of Texas at Dallas Naveen Jindal School of Business (Richardson, TX) 12. St. John’s University Peter J. Tobin College of Business (Jamaica, NY) 13. Georgia Southern University College of Business Administration (Statesboro, GA) 14. Northeastern University D’Amore-McKim School of Business (Boston, MA) 15. DePaul University Kellstadt Graduate School of Business (Chicago, IL) 16. Golden Gate University Edward S. Ageno School of Business (San Francisco, CA) 17. Southern New Hampshire University College of Online and Continuing Education (Hooksett, NH) 18. California State University, Sacramento College of Business Administration (Sacramento, CA) 19. University of Scranton Kania School of Management (Scranton, PA) 20. Syracuse University Martin J. Whitman School of Management (Syracuse, NY) 21. University of Hartford Barney School of Business (West Hartford, CT) 22. University of Miami School of Business Administration (Coral Gables, FL) 23. George Mason University School of Business (Fairfax, VA) 24. University of South Dakota Beacom School of Business (Vermillion, SD) 25. Florida Atlantic University College of Business (Boca Raton, FL) 26. Stetson University M.E. Rinker Sr. Institute of Tax and Accountancy (DeLand, FL) 27. Rider University College of Business Administration (Lawrenceville, NJ) 28. New England College School of Graduate and Professional Studies (Henniker, NH) 29. Western Governors University (Salt Lake City, UT) 30. Indiana Wesleyan University DeVoe School of Business (Marion, IN) 31. Plymouth State University College of Business Administration (Plymouth, NH) 32. Bellevue University College of Business (Bellevue, NE) 33. Loyola University Chicago Quinlan School of Business (Chicago, IL) 34. Franklin University Ross College of Business (Columbus, OH) 35. Nova Southeastern University Huizenga College of Business (Fort Lauderdale, FL) 36. Saint Mary’s University Graduate School of Business and Technology (Winona, MN) 37. Baypath University School of Science & Management (Longmeadow, MA) *See the full rankings and program details here: About is a free online resource focused on providing accurate and up-to-date information on degrees, programs, and schools for prospective master’s in accounting students. The site also provides additional resources such as career outlooks, graduate student guides, scholarships, and more.’s goal is to be best in class.

Stutzmann G.E.,Franklin University | Mattson M.P.,U.S. National Institute on Aging
Pharmacological Reviews | Year: 2011

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle capable of integrating multiple extracellular and internal signals and generating adaptive cellular responses. It plays fundamental roles in protein synthesis and folding and in cellular responses to metabolic and proteotoxic stress. In addition, the ER stores and releases Ca 2+ in sophisticated scenarios that regulate a range of processes in excitable cells throughout the body, including muscle contraction and relaxation, endocrine regulation of metabolism, learning and memory, and cell death. One or more Ca 2+ ATPases and two types of ER membrane Ca 2+ channels (inositol trisphosphate and ryanodine receptors) are the major proteins involved in ER Ca 2+ uptake and release, respectively. There are also direct and indirect interactions of ER Ca 2+ stores with plasma membrane and mitochondrial Ca 2+-regulating systems. Pharmacological agents that selectively modify ER Ca 2+ release or uptake have enabled studies that revealed many different physiological roles for ER Ca 2+ signaling. Several inherited diseases are caused by mutations in ER Ca 2+-regulating proteins, and perturbed ER Ca 2+ homeostasis is implicated in a range of acquired disorders. Preclinical investigations suggest a therapeutic potential for use of agents that target ER Ca 2+ handling systems of excitable cells in disorders ranging from cardiac arrhythmias and skeletal muscle myopathies to Alzheimer disease. © 2011 by The American Society for Pharmacology and Experimental Therapeutics.

Rudwaleit M.,Endokrinologikum Berlin | Sieper J.,Franklin University
Nature Reviews Rheumatology | Year: 2012

The spectrum of HLA-B27-associated inflammatory spine diseases is referred to as axial spondyloarthritis (axSpA). AxSpA encompasses established ankylosing spondylitis (AS) but also nonradiographic axSpA, and can be classified according to the Assessment of SpondyloArthritis international Society classification criteria for axSpA. Specific and effective therapy for axSpA includes education, physiotherapy, NSAIDs and biologic agents, as appropriate. Patients with axSpA, however, are often diagnosed late in the course of the disease. As specific therapy is available, the effective identification of those individuals who are likely to have axSpA among patients with chronic back pain in primary care and their subsequent referral to a rheumatologist for establishing a correct diagnosis is worth pursuing. Candidate referral parameters that can easily be applied to patients with chronic back pain and age at onset ĝ‰ Currency sign45 years (the target population) include inflammatory back pain (IBP) and positivity for HLA-B27. Following diagnostic work-up by a rheumatologist, these referral parameters, either alone or in combination, have led to the diagnosis of as many as 33-45% of patients within this target population with axSpA, 41-62% of whom had undiagnosed AS. Thus, educating primary care physicians on the value of IBP and HLA-B27 testing within this target population, and referral to a rheumatologist if one of these parameters is positive, is a promising approach to reduce the long delay in diagnosing patients with axSpA. © 2012 Macmillan Publishers Limited All rights reserved.

Korfel A.,Franklin University | Schlegel U.,Ruhr University Bochum
Nature Reviews Neurology | Year: 2013

Primary CNS lymphoma (PCNSL) is a rare lymphoma that is confined to the CNS, with low tendency for systemic dissemination and a relatively aggressive course. Outcome in patients with PCNSL is often poor. Owing to its low incidence, current knowledge about optimal treatment of PCNSL is fragmentary. Chemotherapy regimens based on high-dose methotrexate are currently standard treatment for all patients with PCNSL who can tolerate such drugs. Whole-brain radiotherapy alone can lead to remission in up to 90% of patients, but often results in poor long-term disease control when given alone, and in delayed neurotoxicity when given after high-dose methotrexate. In this Review, we describe current approaches to diagnosis and treatment of PCNSL, and discuss novel therapeutic approaches that are currently in development, such as the use of rituximab and high-dose chemotherapy followed by autologous stem-cell transplantation. The possible use of intrathecal and intraventricular chemotherapy, optimal salvage treatment, and specific treatment approaches in elderly, paediatric and immunocompromised patients, are also considered. © 2013 Macmillan Publishers Limited. All rights reserved.

Feldmeier H.,Franklin University
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2012

Pediculosis capitis is a ubiquitous parasitic skin disease caused by Pediculus humanus capitis. Head lice are highly specialised parasites which can propagate only on human scalp and hair. Transmission occurs by direct headto- head contact. Head lice are vectors of important bacterial pathogens. Pediculosis capitis usually occurs in small epidemics in play groups, kindergartens and schools. Population based studies in European countries show highly diverging prevalences, ranging from 1% to 20%. The diagnosis of head lice infestation is made through the visual inspection of hair and scalp or dry/wet combing. The optimal method for the diagnosis of active head lice infestation is dry/wet combing. Topical application of a pediculicide is the most common treatment. Compounds with a neurotoxic mode of action are widely used but are becoming less effective due to resistant parasite populations. Besides, their use is restricted by safety concerns. Dimeticones, silicone oils with a low surface tension and the propensity to perfectly coat surfaces, have a purely physical mode of action. This group of compounds is highly effective and safe, and there is no risk that head lice become resistant. The control of epidemics requires active contact tracing and synchronised treatment with an effective and safe pediculicide. © Springer-Verlag 2012.

To describe the plasma concentration-time profile of moxifloxacin after intravenous and enteral administration in intensive care unit (ICU) patients and to provide a pharmacodynamic (PD) evaluation with regard to pneumonia. Twenty-five adult patients from a cardiothoracic/mixed surgical ICU were enrolled. Moxifloxacin was given as a standard dose (400 mg once daily). Therapy was successfully switched to enteral administration on day 5 in 16 patients. A rich data sampling schedule was performed after intravenous (day 4) and enteral (day 8) administration. Moxifloxacin concentrations were analysed by HPLC. A population pharmacokinetic (PK) model was developed using NONMEM VII. Simulated concentration-time profiles were evaluated for their probability of attaining PK/PD target values relevant for community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP). A linear-elimination two-compartment model described the data adequately. Parameter estimates (coefficient of variation of inter-individual variability) were: absorption rate constant, 1.09/h (135%); enteral bioavailability, 76% (20.0%); central volume of distribution, 55.6 L; peripheral volume of distribution, 59.6 L (15.3%); inter-compartmental clearance, 47.7 L/h; and clearance, 11.3 L/h (23.7%). Both intravenously and enterally administered standard-dose moxifloxacin reliably attained the PK/PD target values for pathogens with MICs ≤ 0.25 mg/L for CAP and ≤ 0.125 mg/L for HAP. Drug exposure to moxifloxacin in ICU patients was more variable than in healthy volunteers. The standard dosing provides sufficient drug exposure for treatment of CAP but for HAP it does so only when a highly susceptible pathogen is present. Intravenous/enteral sequential therapy may be considered for cautiously selected cases in ICU patients.

Paulus W.J.,VU University Amsterdam | Tschope C.,Franklin University
Journal of the American College of Cardiology | Year: 2013

Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling were shown to be specifically altered in heart failure with preserved ejection fraction (HFPEF). A new paradigm for HFPEF development is therefore proposed, which identifies a systemic proinflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations. The new paradigm presumes the following sequence of events in HFPEF: 1) a high prevalence of comorbidities such as overweight/obesity, diabetes mellitus, chronic obstructive pulmonary disease, and salt-sensitive hypertension induce a systemic proinflammatory state; 2) a systemic proinflammatory state causes coronary microvascular endothelial inflammation; 3) coronary microvascular endothelial inflammation reduces nitric oxide bioavailability, cyclic guanosine monophosphate content, and protein kinase G (PKG) activity in adjacent cardiomyocytes; 4) low PKG activity favors hypertrophy development and increases resting tension because of hypophosphorylation of titin; and 5) both stiff cardiomyocytes and interstitial fibrosis contribute to high diastolic left ventricular (LV) stiffness and heart failure development. The new HFPEF paradigm shifts emphasis from LV afterload excess to coronary microvascular inflammation. This shift is supported by a favorable Laplace relationship in concentric LV hypertrophy and by all cardiac chambers showing similar remodeling and dysfunction. Myocardial remodeling in HFPEF differs from heart failure with reduced ejection fraction, in which remodeling is driven by loss of cardiomyocytes. The new HFPEF paradigm proposes comorbidities, plasma markers of inflammation, or vascular hyperemic responses to be included in diagnostic algorithms and aims at restoring myocardial PKG activity. © 2013 by the American College of Cardiology Foundation.

Feldmeier H.,Franklin University
American Journal of Clinical Dermatology | Year: 2014

Pediculosis capitis is the most common ectoparasitic disease in children in industrialized countries and extremely common in resource-poor communities of the developing world. The extensive use of pediculicides with a neurotoxic mode of action has led to the development and spread of resistant head lice populations all over the world. This triggered the development of compounds with other modes of action. The current literature on treatment approaches of head lice infestation was searched, and published randomized controlled trials were critically analyzed. The following compounds/family of compounds were identified: spinosad, a novel compound with a new neurotoxic mode of action, isopropyl myristate, 1,2-octanediol, ivermectin, plant-based products, and dimeticones. The efficacy and safety of these compounds are reviewed and recommendations for the treatment of pediculosis capitis in individuals as well as the interruption of ongoing epidemics are provided. © 2014, Springer International Publishing Switzerland.

Franklin University | Date: 2011-08-05

The present invention provides a new method for recombinantly expressing a protein of interest, such as the human BR-CA2 protein, BLM protein, CtIP protein, or EXOI protein, by expressing the protein in the form of a fusion protein comprising two maltose-binding protein (MBP) or glutathione-S-transferase (GST) tags. The expression cassette useful for this method and the fusion protein produced by this method are also described.

Two protein families that represent major components of essential amino acid transport in insects have been identified. They are annotated as the SLC6 and SLC7 families of transporters according to phylogenetic proximity to characterized amino acid transporters (HUGO nomenclature). Members of these families have been identified as important apical and basolateral parts of transepithelial essential amino acid absorption in the metazoan alimentary canal. Synergistically, they play critical physiological roles as essential substrate providers to diverse metabolic processes, including generic protein synthesis. This review briefly clarifies the requirements for amino acid transport and a variety of amino acid transport mechanisms, including the aforementioned families. Further it focuses on the large group of Nutrient Amino acid Transporters (NATs), which comprise a recently identified subfamily of the Neurotransmitter Sodium Symporter family (NSS or SLC6). The first insect NAT, cloned from the caterpillar gut, has a broad substrate spectrum similar to mammalian B 0 transporters . Several new NAT-SLC6 members have been characterized in an effort to explore mechanisms for the essential amino acid absorption in model dipteran insects. The identification and functional characterization of new B 0-like and narrow specificity transporters of essential amino acids in fruit fly and mosquitoes leads to a fundamentally important insight: that NATs evolved and act together as the integrated active core of a transport network that mediates active alimentary absorption and systemic distribution of essential amino acids. This role of NATs is projected from the most primitive prokaryotes to the most complex metazoan organisms, and represents an interesting platform for unraveling the molecular evolution of amino acid transport and modeling amino acid transport disorders. The comparative study of NATs elucidates important adaptive differences between essential amino acid transportomes of invertebrate and vertebrate organisms, outlining a new possibility for selective targeting of essential amino acid absorption mechanisms to control medically and economically important arthropods and other invertebrate organisms. © 2011 Elsevier Ltd.

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