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Franklin, IN, United States

Franklin College is a sixth form college on Chelmsford Avenue in Grimsby, North East Lincolnshire, England, serving more than 2,700 students, including adult learners. Wikipedia.

Fok H.,Kings College And Kings Health Partners | Cruickshank J.K.,Franklin College
Current Hypertension Reports | Year: 2015

Isolated systolic hypertension is the commonest form of hypertension from middle age onwards. Achieving target systolic blood pressure (BP) control remains difficult in everyday clinical practice and even under clinical trial conditions. Most antihypertensive medicines were designed to lower peripheral vascular resistance, which was considered the haemodynamic determinant of hypertension; most are effective in reducing steady but not pulsatile components of BP. Arterial stiffness, defined via aortic length-specific pulse wave velocity (PWV), is thought to be an important determinant of pulse pressure widening through its effects on the timing and amplitude of pressure wave reflection, and/or the aorta’s Windkessel function, or its excess ‘reservoir’ pressure. Whereas pulse pressure is neither an independent nor consistent cardiovascular risk factor, particularly below the age of about 60 years, PWV has become the most powerful predictor of cardiovascular outcomes including mortality, independent of systolic, pulse, mean or other BP components. PWV is therefore a more direct target for treatment. This review addresses the potential therapeutic options for targeting arterial stiffness and the role of pulse pressure. © 2015, Springer Science+Business Media New York. Source

Traditional natural resource management approaches often focus on a specific natural resource and ignore social components other than economic value. In contrast, new approaches to resource management, such as those employing ecosystem management strategies, recognize and strive to incorporate other social components of the managed system. This study uses a content analysis of regional newspaper coverage of two relatively new reserves in river-floodplain systems, the Lower Wisconsin State Riverway and the Middle Elbe Biosphere Reserve, to analyze each reserve's success in managing the social components of its resources during each reserve's first ten years. The results suggest that positive coverage of both reserves has increased, as has the perceived authority of the reserve staff, as measured by trends in the quantity of direct quotes. The Middle Elbe Biosphere Reserve received approximately three times more coverage than its Wisconsin counterpart, suggesting that the more extensive public outreach program of the former is an important tool in dealing with social issues within a conservation reserve. © 2010 Springer Science+Business Media, LLC. Source

Anderson M.L.,Franklin College
Behavioral and Brain Sciences | Year: 2015

Neural reuse is a form of neuroplasticity whereby neural elements originally developed for one purpose are put to multiple uses. A diverse behavioral repertoire is achieved via the creation of multiple, nested, and overlapping neural coalitions, in which each neural element is a member of multiple different coalitions and cooperates with a different set of partners at different times. This has profound implications for how we think about our continuity with other species, for how we understand the similarities and differences between psychological processes, and for how best to pursue a unified science of the mind. After Phrenology surveys the terrain and advocates for a series of reforms in psychology and cognitive neuroscience. The book argues that, among other things, we should capture brain function in a multi-dimensional manner, develop a new, action-oriented vocabulary for psychology, and recognize that higher-order cognitive processes are built from complex configurations of already evolved circuitry. Copyright © Cambridge University Press 2015 Source

Gnudi L.,Franklin College
Diabetologia | Year: 2016

Diabetic nephropathy is the main cause of end-stage renal failure in the Western world. In diabetes, metabolic and haemodynamic perturbations disrupt the integrity of the glomerular filtration barrier, leading to ultrastructural alterations of the glomeruli, including podocyte foot process fusion and detachment, glomerular basement membrane thickening, reduced endothelial cell glycocalyx, and mesangial extracellular matrix accumulation and glomerulosclerosis, ultimately leading to albuminuria and end-stage renal disease. Many vascular growth factors, such as angiopoietins, are implicated in glomerular biology. In normal physiology angiopoietins regulate the function of the glomerular filtration barrier. When they are dysregulated, however, as they are in diabetes, they drive the cellular mechanisms that mediate diabetic glomerular pathology. Modulation of angiopoietins expression and signalling has been proposed as a tool to correct the cellular mechanisms involved in the pathophysiology of diabetic microvascular disease, such as retinopathy in humans. Future work might evaluate whether this novel therapeutic approach should be extended to diabetic kidney disease. © 2016 The Author(s) Source

Ito T.,Franklin College | Ito T.,University of California at San Diego
International Journal of Hematology | Year: 2013

Chronic myeloid leukemia (CML) is a cancer of blood cells driven by the BCR-ABL1 oncogenic protein tyrosine kinase, which is the product of a reciprocal chromosomal translocation known as the Philadelphia chromosome. Discovery of tyrosine kinase inhibitors targeting the BCR-ABL1 kinase revolutionized CML therapy, but these drugs are unable to eradicate the disease due to the presence of a drug-insensitive stem cell population that sustains continued growth of the malignant cells. Resistance to therapies also increases the risk of relapse and disease progression to a more advanced phase. This review discusses emerging issues in CML research, and describes recent progress in elucidating the mechanisms of CML stem cell maintenance and disease progression. © 2013 The Japanese Society of Hematology. Source

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