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Bi D.-M.,Langfang Fourth Peoples Hospital | Dong Y.-L.,Langfang Fourth Peoples Hospital | Wu J.-P.,Langfang Fourth Peoples Hospital | Wang X.-N.,Langfang Fourth Peoples Hospital | And 3 more authors.
World Chinese Journal of Digestology | Year: 2015

AIM: To explore the expression of Caspase3, P53 and Ki-67 in colon cancer and colon adenoma. METHODS: The expression of Caspase3, P53 and Ki-67 in 100 colon cancer tissues and 100 colon adenoma tissues was detected by immunohistochemistry.Correlations between Caspase3, P53 and Ki-67 expression and between their expression and clincopatholgical parameters were investigated using Spearman correlation analysis. RESULTS: The expression of Caspase3, P53 and Ki-67 had no significant correlation with age, sex, tumor differentiation or infiltration (P > 0.05). The positive expression rates of Caspase3, P53 and Ki-67 differed significantly between the lymph node metastasis group (18.18%, 31.82%, and 90.91%, respectively) and non-lymph node metastasis group (52.56%, 89.74%, and 61.54%, respectively) and between Duke's stage A-B (52.56%, 89.74%, and 61.54%, respectively) and C-D (18.18%, 31.82%, and 90.91%, respectively) (P < 0.05). The positive expression rates of Caspase3, P53 and Ki-67 were 45.00%, 77.00% and 68.00%, respectively, in colon cancer tissues and 83.00%, 49.00% and 26.00%, respectively, in adenoma tissues (P < 0.01). The expression of P53 was positively correlated with that of Caspase3 (r = 0.315, P < 0.01), but negatively correlated with that of Ki-67 (r = -0.302, P < 0.01). CONCLUSION: Caspase3, P53 and Ki-67 are all involved in the development and progression of colon cancer, and combined detection of their expression can help determine the invasion, metastasis and prognosis of this malignancy. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

Yang L.,Langfang Fourth Peoples Hospital | Liu C.,Chinese PLA General Hospital | Hua W.,Langfang Fourth Peoples Hospital | Liu W.,Langfang Fourth Peoples Hospital | And 5 more authors.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2013

To explore the procedure and effectiveness of sequential reduction and fixation for zygomatic complex fractures. Between March 2004 and February 2012, 32 patients with zygomatic complex fractures were treated. There were 28 males and 4 females with a median age of 29 years (range, 17-55 years). Fractures were caused by traffic accident in 29 cases and by tumble in 3 cases. The time between injury and admission was 1-12 days (mean, 3 days) in 28 fresh fractures and 22-60 days (mean, 40 days) in 4 old fractures. All patients were diagnosed by clinical symptom and CT scan. Coronal scalp incision, lower eyelid aesthetic incision, and intraoral incision were used to expose the zygomatic bone segments. The sequence of fractures reduction and fixation was horizontal first, and then longitudinal. In horizontal orientation, reduction and simultaneous fixation started from the root of the zygoma, to zygomatic arch, body of the zygoma, and inferior orbital rim in turn. Longitudinally, fracture reduction of zygomatico-frontal suture and orbital posterolateral walls was done first, followed by fracture reduction of zygomaticomaxillary buttress. Primary healing of incision was obtained in all 32 cases, without complications of maxillary sinus fistula and infection. Eighteen patients were followed up 6 months to 6 years with a median time of 32 months. All the patients gained satisfactory results with normal zygomatic contour and symmetric midface. All patients restored normal mouth opening. No eye and vision damage occurred. Frontal disappearance and brow ptosis were observed in 2 cases. Hair loss (2-3 mm) was seen at the site of coronal scalp incision, without scar hyperplasia; there was no obvious scar at lower eyelid. CT and X-ray films showed bony healing at 6 months after operation. Sequential reduction and fixation is accord with the mechanical characters of complicated zygomatic fractures. It is very easy to achieve anatomic reduction of the bone segments and facial symmetry. Source

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