Tianjin Fourth Central Hospital

Tianjin, China

Tianjin Fourth Central Hospital

Tianjin, China
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Xu Z.,Tianjin Fourth Central Hospital | Li G.,Center for Cancer Genomic and Center for Human Genomic
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2014

To study the gender differences of amount of neurons in the nodose ganglions of rats. Fourteen Sprague-Dawley rats (7 males and 7 females) were selected. Bilateral nodose ganglions were dissected and serial sections of nodose ganglion were cut in a cryostat, followed by Cresyl-violet staining for neurons. Eight to ten consecutive sections from mid-portion of each nodose ganglion sample, which represent the most neuron number per section, were counted and averaged. Gender difference in the amount of neurons in the nodose ganglions was compared. No gender difference of neuron numbers was found in either side of nodose ganglion (p > 0.05). However, average neuron number of nodose ganglions on the left side of male (654 ± 60) and female (616 ± 37) were significantly more than that on the right side of male (470 ± 22) and female (453 ± 40) respectively (p < 0.05). There is no gender difference in total neuron number of nodose ganglions between male and female rat. However, the neuron number in the left nodose ganglion is greater than that in the right one. The difference may be due to the fact that left and right nodose ganglion is receiving different visceral sensory impulses separately, which is associated with different physiological functions. Further work should be carried out with retrograde tracing on neurons of nodose ganglions in an animal model, which are directly related to laryngeal sensory transmission, in order to determine the gender difference in the neuron number and morphology related to laryngeal functions. © 2012 Association of Otolaryngologists of India.


PubMed | Tianjin Nankai Hospital and Tianjin Fourth Central Hospital
Type: Journal Article | Journal: Cell biology and toxicology | Year: 2016

In the present study, we determined the protective role of lutein against A


Zhang J.-J.,Tianjin Fourth Central Hospital | Shi H.-C.,Tianjin Fourth Central Hospital | Yang W.-S.,Tianjin Fourth Central Hospital | Wang D.,Tianjin Fourth Central Hospital
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Clinical studies have demonstrated that systemic mild hypothermia could significantly reduce the disability and mortality rate of patients with severe traumatic brain injury. In recent years, the researches about the treatment of spinal cord injury by mild hypothermia have been successively carried out. OBJECTIVE: To investigate the effects of mild hypothermia on nerve regeneration microenvironment after spinal cord injury and explore the possible underlying mechanism of nerve regeneration and functional recovery after spinal cord injury in rats. METHODS: Twenty out of sixty-seven rats were randomly selected as the sham group, and other rats were used to establish spinal cord injury models in T9 segment using modified Allen’s method. Three rats were excluded for failure in spinal cord injury induction and four rats for death during modeling. The rest 40 rats were randomly and evenly divided into the spinal cord injury and mild hypothermia groups (n=20 rats/group). The rats in the sham and spinal cord injury groups were placed in the operating table with normal temperature, making their rectal temperature at 37.0±0.5 "C for 72 hours. The rats in the mild hypothermia group were placed on ice blanket machine, making their rectal temperature at 34.0±0.5 "C for 72 hours, then the temperature was naturally rewarmed. RESULTS AND CONCLUSION: Compared with spinal cord injury group, the apoptosis index and the level of aquaporin 4/9 mRNA and protein expression in spinal cord injury tissue were all decreased, somatosensory evoked potential latency and amplitude were recovered, and the motor functional scores were increased in the mild hypothermia group. These results indicate that mild hypothermia play its protective effect on spinal cord injury through attenuating apoptosis of neural cells and decreasing aquaporin 4/9 mRNA and protein expression levels. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Liu J.,Tianjin Fourth Central Hospital | Sun H.,Tianjin Fourth Central Hospital | Wang S.,Tianjin Fourth Central Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2014

OBJECTIVE: To investigate and analyze the candida infection situation at the intensive care unit (ICU) in Tianjin Fourth Central Hospital from 2008 to 2012.METHODS: Critically ill patients admitted in ICU Department in Tianjin Fourth Central Hospital from Jan. 2008 to Dem. 2012 were selected, and candida in all blood, sputum and other specimens of patients, were tested. Data on the following items as:hospital sections and distribution of candida infection on the places where the fungus was identified, distribution of different species of candida, antifungal drug resistance of candidates commonly used in ICU department in the last five years etc., were statistically analyzed.RESULTS: Among 4 529 cases of critically ill patients stayed in the hospital ICU Department between 2008 and 2012, 76 cases of candida infection were identified, with the rate as 1.68%. In the past five years, candida in hospital ICU was mainly detected in sputum samples in 52 cases which accounted for 68.4%. Another 9 cases were detected in blood, accounted for 11.8%, 8 cases were detected in urine, which accounted for 10.5% , 36 cases (47.4%) of candida infection detected at the hospital ICU department in the last 5 years with major species as Candida albicans infection, followed by Candida glabrata, Candida tropicalis, Candida parapsilosis and Portugal Candida. The highest rate of resistance was to itraconazole, with a resistance rate of 19.7%, followed by voriconazole, with the rate as 15.8%.CONCLUSION: In recent years, the number of patients infected with candida at the ICU department had increased annually with most cases as respiratory infections, which were caused by Candida albicans. The rate of resistance of candida to itraconazole was the highest, which called for special attention.


Wang D.,Tianjin Fourth Central Hospital
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2010

Bone marrow mesenchymal stem cells (BMSCs) play an important role in repairing nerve injury, meanwhile external temperature has significant effect on BMSCs transplantation, proliferation, and differentiation. To investigate the effect of BMSCs transplantation and mild hypothermia on repair of rat spinal cord injury (SCI). Forty-five female adult SD rats (weighing 200-250 g) were made the models of hemitransection SCI and divided randomly into 3 groups according to different treatments: group A (SCI group), group B (BMSCs transplantation group), and group C [BMSCs transplantation combined with mild hypothermia (33-35 degrees C) group]. At 1, 2, 4, 6, and 8 weeks after injury, the function of hind limb was evaluated with Basso Beattie and Bresnahan (BBB) score and inclined plane test. At 4 weeks after injury, histopathology and BrdU immunohistochemistry staining were performed. At 8 weeks after injury, horseradish peroxidase (HRP) retrograde nerve trace and transmission electron microscope (TEM) testing were performed to observe the regeneration of axon. After 4 weeks, the function of hind limb obviously recovered in groups B and C, there were significant differences in BBB score between groups B, C and group A (P < 0.05), between group B and group C (P < 0.05). There was no significant difference (P > 0.05) in tilt angle among 3 groups after 1 and 2 weeks, and there were significant differences (P < 0.05) among 3 groups after 4 weeks. HE staining showed that significant cavity could be seen in group A, little in group B, and no cavity in group C. BrdU immunohistochemistry staining showed that the number of positive cells was 0, 90.54 +/- 6.23, and 121.22 +/- 7.54 in groups A, B, and C, respectively; showing significant differences (P < 0.01) among 3 groups. HRP retrograde neural tracing observation showed that the number of HRP positive nerve fibers was 10.35 +/- 1.72, 43.25 +/- 2.65, and 84.37 +/- 4.59 in groups A, B, and C, respectively, showing significant differences (P < 0.01) among 3 groups. TEM observation showed that a great amount of unmyelinated nerve fibers and myelinated nerve fibers were found in central transverse plane in group C. The BMSCs transplantation play an important role in promotion of recovering the function of hind limb after SCI, and mild hypothermia has synergism effects.


Zhang L.,Tianjin Fourth Central Hospital | Sun W.-W.,Tianjin Fourth Central Hospital | Fu L.-N.,Tianjin Fourth Central Hospital
World Chinese Journal of Digestology | Year: 2014

AIM: To evaluate the impact of nursing intervention combined with Care for Life in Science (CLS) biological treatment on the prognosis of patients with digestive system tumors. METHODS: Eighty gastrointestinal cancer patients treated at Tianjin Fourth Central Hospital from January 2011 to December 2011 were randomly divided into either an intervention group or a conventional group. The conventional group received CLS biological treatment combined with routine care, while the intervention group underwent nursing intervention combined with CLS biological treatment. Clinical effects were compared between the two groups. RESULTS: The intervention group had significantly higher 2- and 3-year survival rates than the conventional group (85.7% vs 70.0%, 75.0% vs 60.0%, P < 0.05). Appetite, pain and disease awareness and activities of daily living were significantly better in the intervention group than in the conventional group (t = 5.017, 6.332, 8.407, 9.352, P < 0.05). CONCLUSION: CLS biological treatment combined with care intervention is feasible and can improve the patient’s prognosis. © 2014 Baishideng Publishing Group Inc. All rights reserved.


Luo Z.K.,Tianjin Fourth Central Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To observe the clinical efficacy and safety of Puerarin Injection treatment on angina pectoris. 388 patients with angina pectoris, enrolled to Tianjin Fourth Central Hospital during January 2009 and February 2011 were selected and randomly divided into treatment or control groups with 194 patients of each. Based on the conventional therapy program, one group was given Puerarin Injection as treatment group while, the other was given with Danshen Injection as control group. Clinical efficacy, the attack rate of angina pectoris, oxygen consumption, indices on electrocardiogram, haemorheology and other adverse reactions among the two groups were compared. The total efficacy of the treatment group (88.14%, 171/194) was significantly higher than the control group (61.86%, 120/194) and the difference was statistically significant (P < 0.05). During the treatment, no significant adverse events were noticed in both of the two groups of patients. The Puerarin Injection treatment program on angina pectoris seemed effective and safe.


PubMed | Tianjin Fourth Central Hospital
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To observe the clinical efficacy and safety of Puerarin Injection treatment on angina pectoris.388 patients with angina pectoris, enrolled to Tianjin Fourth Central Hospital during January 2009 and February 2011 were selected and randomly divided into treatment or control groups with 194 patients of each. Based on the conventional therapy program, one group was given Puerarin Injection as treatment group while, the other was given with Danshen Injection as control group. Clinical efficacy, the attack rate of angina pectoris, oxygen consumption, indices on electrocardiogram, haemorheology and other adverse reactions among the two groups were compared.The total efficacy of the treatment group (88.14%, 171/194) was significantly higher than the control group (61.86%, 120/194) and the difference was statistically significant (P < 0.05). During the treatment, no significant adverse events were noticed in both of the two groups of patients.The Puerarin Injection treatment program on angina pectoris seemed effective and safe.


PubMed | Tianjin Fourth Central Hospital
Type: Journal Article | Journal: Saudi medical journal | Year: 2017

To investigate whether there is a difference in carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 72-4 (CA72-4), and neuron-specific enolase (NSE) between diabetic and non-diabetic patients.Methods: A retrospective analysis was performed in 268 type 2 diabetic patients and 95 non-diabetic ones, and their serum levels of CA19-9, CEA, CA72-4, and NSE were compared in our endocrine ward at the Tianjin Fourth Central Hospital, Tianjin, Chinaduring the period from January to June 2015. The diabetic patients were divided into 4 groups based on glycosylated hemoglobin (HbA1c) levels to investigate the relationship between levels of tumor markers and glucose status.Results: Diabetic patients had higher levels of tumor markers than non-diabetic subjects (CA19-9: 13.0 versus 7.25U/mL, p=0.000; CEA: 2.55 versus 2.25 ng/mL, p=0.012; CA72-4: 1.95 versus 1.50U/mL, p=0.001; NSE: 11.64 versus 10.22ng/mL, p=0.000). CA19-9 levels increased in a stepwise manner with poor diabetes status. CEA levels were increased in patients with HbA1c 9% and CA72-4 elevation was predominant in patients with poor glycemic control (HbA1c 11%). NSE levels were not associated with metabolic parameters.Conclusion: Serum levels of CA19-9, CEA, CA72-4, and NSE were elevated in type 2 diabetes; however, only CA19-9, CEA, and CA72-4 levels were associated with hyperglycemia.


PubMed | Tianjin Fourth Central Hospital
Type: Journal Article | Journal: Neural regeneration research | Year: 2015

Following successful establishment of a rat model of spinal cord hemisection injury by resecting right spinal cord tissues, bone marrow stem cells were transplanted into the spinal cord lesions via the caudal vein while maintaining rectal temperature at 34 0.5C for 6 hours (mild hypothermia). Hematoxylin-eosin staining showed that astrocytes gathered around the injury site and formed scars at 4 weeks post-transplantation. Compared with rats transplanted with bone marrow stem cells under normal temperature, rats transplanted with bone marrow stem cells under hypothermia showed increased numbers of proliferating cells (bromodeoxyuridine-positive cells), better recovery of somatosensory-evoked and motor-evoked potentials, greater Basso, Beattie, and Bresnahan locomotor rating scores, and an increased degree of angle in the incline plate test. These findings suggested that hypothermia combined with bone marrow mesenchymal stem cells transplantation effectively promoted electrical conduction and nerve functional repair in a rat model of spinal cord hemisection injury.

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