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Tie L.-J.,Xian Jiaotong University | Yu H.,Foshan Maternal and Child Health Care Hospital | Huang S.-J.,Foshan Maternal and Child Health Care Hospital
Biological Rhythm Research | Year: 2010

Sleep plays a critical role in children's development. Sleep not only impacts on physical growth, behaviour, and emotional development but also is closely related to cognitive functioning, learning, and attention. Sleep problems that include nightmares, night terrors, sleep talking, sleepwalking, bed-wetting, teeth grinding and snoring are very common in Chinese children. In recent years, there has been improvement in the epidemiology of sleep problems in children of different ages in China. Despite growing research efforts, the aetiology of sleep problems has not been clearly identified. A number of surveys suggest that, in addition to biological determinants of sleep, sleep quality appears to be influenced in part by social, cultural and familial issues. In this review, we focus on assessing cultural aspects of sleep in Chinese children of different ages, especially young children. Particular emphasis is given to sociocultural factors (co-sleeping, transitional objects, child-rearing practices, feeding practices, sleep position) and familial environment that are related to the bedtime behaviour of children. © 2010 Taylor & Francis. Source


Zhao J.,Foshan Maternal and Child Health Care Hospital | Lei T.,Zhongshan Peoples Hospital | Xu C.,Pepoles Hospital of Hainan Province | Li H.,Foshan Maternal and Child Health Care Hospital | And 4 more authors.
Biochemical and Biophysical Research Communications | Year: 2013

Aberrantly expressed microRNAs (miRNAs) are frequently associated with the aggressive malignant behavior of human cancers, including clear cell renal cell carcinoma (ccRCC). Based on the preliminary deep sequencing data, we hypothesized that miR-187 may play an important role in ccRCC development. In this study, we found that miR-187 was down-regulated in both tumor tissue and plasma of ccRCC patients. Lower miR-187 expression levels were associated with higher tumor grade and stage. All patients with high miR-187 expression survived 5. years, while with low miR-187 expression, only 42% survived. Suppressed in vitro proliferation, inhibited in vivo tumor growth, and decreased motility were observed in cells treated with the miR-187 expression vector. Further studies showed that B7 homolog 3 (B7-H3) is a direct target of miR-187. Over-expression of miR-187 decreased B7-H3 mRNA level and repressed B7-H3-3'-UTR reporter activity. Knockdown of B7-H3 using siRNA resulted in similar phenotype changes as that observed for overexpression of miR-187. Our data suggest that miR-187 is emerging as a novel player in the disease state of ccRCC. miR-187 plays a tumor suppressor role in ccRCC. © 2013 Elsevier Inc. Source


Li H.,Foshan Maternal and Child Health Care Hospital | Zhao J.,Foshan Maternal and Child Health Care Hospital | Zhang J.W.,Foshan Maternal and Child Health Care Hospital | Huang Q.Y.,Foshan Maternal and Child Health Care Hospital | And 6 more authors.
Neoplasma | Year: 2013

Aberrantly expressed microRNAs (miRNAs) are frequently correlated with a variety of human cancers, including clear cell renal cell carcinoma (ccRCC). In this study, we determined the expression patterns of miR-217 in ccRCC, and tested its effect on cancer cell proliferation and migration. The expression levels of miR-217 were determined in 54 ccRCC samples using Real-Time qPCR. 786-O and ACHN cells were transfected with miR-217 mimics or miRNA mimics control. Cell proliferation and migration were evaluated by MTT assay and scratch-wound assay, respectively. We found that miR-217 was down-regulated in ccRCC compared to paired normal tissue. Lower miR-217 expression levels were associated with higher tumor grade and stage. All patients with high miR-217 expression survived 5 years, while with low miR-217 expression, only 40% survived. Cell proliferation inhibition and decreased motility were observed in cells transfected with the miR-217 mimics. In conclusion, miR-217 plays a tumor suppressor role in ccRCC. Source


Gao X.-Y.,Foshan Maternal and Child Health Care Hospital | Gao P.-M.,Foshan Maternal and Child Health Care Hospital | Wu S.-G.,Foshan Maternal and Child Health Care Hospital | Mai Z.-G.,Foshan Maternal and Child Health Care Hospital | And 14 more authors.
Chinese Journal of Contemporary Pediatrics | Year: 2016

Objective: To investigate the risk factors for the development of congenital anal atresia in neonates. Methods: A total of 70 neonates who were admitted to 17 hospitals in Foshan, China from January 2011 to December 2014 were enrolled as case group, and another 70 neonates who were hospitalized during the same period and had no anal atresia or other severe deformities were enrolled as control group. Univariate and multivariate logistic regression analyses were used to investigate the risk factors for the development of congenital anal atresia. Results: The univariate analysis revealed that the age of mothers, presence of oral administration of folic acid, infection during early pregnancy, and polyhydramnios, and sex of neonates showed significant differences between the case and control groups (P<0.05). The multivariate logistic regression analysis revealed that infection during early pregnancy (OR=18.776) and male neonates (OR=9.304) were risk factors for congenital anal atresia, and oral administration of folic acid during early pregnancy was the protective factor (OR=0.086). Conclusions: Infection during early pregnancy is the risk factor for congenital anal atresia, and male neonates are more likely to develop congenital anal atresia than female neonates. Supplementation of folic acid during early pregnancy can reduce the risk of congenital anal atresia. Copyright © 2016 Chinese Journal Of Contemporary Pediatrics. All rights reserved. Source

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