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Schwarz M.A.,Forschungs und Beratungsinstitut Gefahrstoffe | Behnke A.,Biochemisches Institute For Umweltcarcinogene | Brandt M.,Umweltbundesamt | Eisentrager A.,Biochemisches Institute For Umweltcarcinogene | And 3 more authors.
Integrated Environmental Assessment and Management | Year: 2014

Semipolar polycyclic aromatic compounds (sPACs) are frequently found in association with homocyclic polycyclic aromatic hydrocarbons (PAHs) in substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) from coal or crude oil and products derived thereof. However, major information deficiencies exist with regard to their prevalence and their toxicological and ecotoxicological potential, persistency, and bioaccumulation characteristics. Therefore, in this work, the environmental concern and relevance of sPACs was addressed in a general, stepwise approach. First, a large list of sPACs was collected and subsequently refined by assessing their persistence, bioaccumulation, and toxicity (PBT) properties by quantitative structure-activity relationship (QSAR) methods and their relevance by determining their respective frequency of occurrence. In this way, 15 priority sPACs were identified. These 15 priority sPACs were further characterized in detail with respect to their ecotoxicological properties, environmental behavior, carcinogenicity, and genotoxicity attributes. All of these 15 substances were quantified in distillate or product samples. In the next step, some principles for nomination of indicator substances, indicative for the overall content of sPACs, are derived. Data gaps on ecotoxicological endpoints preclude final conclusions, but the respective necessary supplemental tests were identified. Five of the 15 sPACs were tentatively characterized as potential substances of very high concern (SVHC) for the environment. The overall results of this study also clearly show that regulatory risk management of homocyclic PAHs within the European Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) does not address the environmental concern created by sPACs within UVCBs from coal or crude oil. The study proves the need for additional regulatory steps under REACH and suggests indicator substances for their enforcement. © 2014 SETAC. Source


Kersting K.,Berufsgenossenschaft der Bauwirtschaft | Ruhl R.,Berufsgenossenschaft der Bauwirtschaft | Heine K.,Forschungs und Beratungsinstitut Gefahrstoffe | Kalberlah F.,Forschungs und Beratungsinstitut Gefahrstoffe | Geier J.,Informationsverbund Dermatologischer Kliniken IVDK
Gefahrstoffe Reinhaltung der Luft | Year: 2013

Cured epoxy resins are notable for their outstanding technical properties. However, the use of these products before they have cured presents a risk of allergic skin disease. Epoxy resins used in the construction sector are one of the most common triggers of allergic skin reactions among men in Germany Several approaches exist to reducing the allergy risk; rarely however can a substitute substance be found for the epoxy resin. In some cases, a product with a weaker sensitizing action can be used. Corresponding results of a new research project have been published. Suitable gloves have for some years been indicated as personal protective equipment for use with solvent-free epoxy resins. This protective measure must be given greater and proper consideration In industrial use. Source

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