Cambridge, ME, United States
Cambridge, ME, United States
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The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.


The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.


The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.


Patent
FORMA Therapeutics | Date: 2016-09-02

The present invention is directed to compounds of Formula I:


Patent
FORMA Therapeutics | Date: 2016-11-18

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R_(1), R_(2), R_(3), R_(3), R_(4), R_(5), X_(1), X_(2), X_(3), X_(4), and n are described herein.


The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W_(1), W_(2), W_(3), R_(1)-R_(6), and R_(9 )are described herein.


Patent
FORMA Therapeutics | Date: 2016-05-12

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R^(1), R^(2), R^(5), and R^(8 )are as described herein.


Patent
FORMA Therapeutics | Date: 2016-05-12

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R_(1), R_(2), R_(4 )and R_(7 )are defined herein.


Patent
FORMA Therapeutics | Date: 2016-05-12

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R^(1), R^(2), R^(5), and R^(8 )are as described herein.


Patent
FORMA Therapeutics | Date: 2016-05-12

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R_(1), R_(2), R_(4 )and R_(7 )are defined herein.

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