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Marinkovic N.,University of Zagreb | Pasalic D.,University of Zagreb | Ferencak G.,Medikol Outpatient Clinic | Grskovic B.,Forensic Science Center Ivan Vucetic | Rukavina A.S.,University of Zagreb
Arhiv za Higijenu Rada i Toksikologiju | Year: 2010

The term dioxins usually refers to polychlorinated dibenzo-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). As 2,3,7,8-tetrachloro-dibenzo-p- dioxin (TCDD) has the highest toxic potential, the toxic potentials of other PCDDs and PCDFs are defined in comparison with it. Human exposure to dioxins can be environmental (background), occupational, or accidental pollution. In the human body, dioxins are in part metabolised and eliminated, and the rest is stored in body fat. People vary in their capacity to eliminate TCDD, but it is also dose-dependent; the elimination rate is much faster at higher than lower levels. The liver microsomal P4501A1 enzyme oxygenates lipophilic chemicals such as dioxins. It is encoded by the CYP1A1 gene. Cytosolic aryl hydrocarbon receptor (AhR) mediates their carcinogenic action. It binds to dioxin, translocates to nucleus and together with hydrocarbon nuclear translocator (ARNT) and xenobiotic responsive element (XRE) increases the expression of CYP1A1.Dioxins are classified as known human carcinogens, but they also cause noncancerous effects like atherosclerosis, hypertension, and diabetes. Long-term exposures to dioxins cause disruption of the nervous, immune, reproductive, and endocrine system. Short-term exposure to high levels impairs the liver function and causes chloracne. The most sensitive population to dioxin exposure are the foetuses and infants.A large number of health effects have been documented in the scientific literature, and they all place dioxins among the most toxic chemicals known to man.

Cukelj N.,University of Zagreb | Jakasa I.,University of Zagreb | Sarajlija H.,Forensic Science Center Ivan Vucetic | Novotni D.,University of Zagreb | Curic D.,University of Zagreb
Talanta | Year: 2011

Whole grain cereals are an important source of bioavailable lignans, the group of compounds with potential anti-cancerogenic, antioxidant, anti-proliferative, pro-apoptotic, and antiangiogenic properties. The aim of this work was to develop a sensitive method for determination of wheat bran lignans. The analysis of lignans secoisolariciresinol, hydroxymatairesinol, lariciresinol, matairesinol, pinoresinol, syringaresinol is based on derivatization with pentafluoropropionic anhydride (PFPA) and gas chromatography-electron capture detection (GC-ECD), using styrene glycol as internal standard. To our knowledge, this is the first time that EC detection has been used for lignan analysis. The results show that the technique is reproducible and sensitive enough for detecting lignans in wheat at parts-per-billion (ppb) levels, except for hydroxymatairesinol. The method developed showed good recovery (85-105%) and precision (4-20%) for five types of lignans and thus represents a simpler and more affordable alternative to state-of-the-art wheat lignan liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. © 2010 Elsevier B.V. All rights reserved.

Salihovic M.P.,Institute for Anthropological Research | Baresic A.,Institute for Anthropological Research | Klaric I.M.,Institute for Migration and Ethnic Studies | Cukrov S.,Forensic Science Center Ivan Vucetic | And 2 more authors.
American Journal of Physical Anthropology | Year: 2011

The Roma are comprised of many founder groups of common Indian origins but different socio-cultural characteristics. The Vlax Roma are one of the founder Roma populations characterized by a period of bondage in the historic Romanian principalities, and by the archaic Romanian language. Demographic history suggests different migration routes of Roma populations, especially after their arrival in Mesopotamia and the eastern boundary of the Byzantine Empire. Although various genetic studies of uniparental genetic markers showed a connection between Roma genetic legacy and their migration routes, precise sampling of Roma populations elucidates this relationship in more detail. In this study, we analyzed mitochondrial DNA of 384 Croatian Vlax Roma from two geographic locations in the context of 734 European Roma samples. Our results show that Roma migration routes are marked with two Near-Eastern haplogroups, X2 and U3, whose inverse proportional incidence clearly separates the Balkan and the Vlax Roma from other Roma populations that reached Europe as part of the first migration wave. Spatial and temporal characteristics of these haplogroups indicate a possibility of their admixture with Roma populations before arrival in Europe. Distribution of haplogroup M35 indicates that all Vlax Roma populations descend from one single founder population that might even reach back to the original ancestral Indian population. Founder effects followed by strict endogamy rules can be traced from India to contemporary small, local communities, as in the case of two Croatian Vlax Roma populations that show clear population differentiation despite similar origins and shared demographic history. Copyright © 2011 Wiley-Liss, Inc.

Kerolli-Mustafa M.,University of Prishtina | Bacic I.,Forensic Science Center Ivan Vucetic | Curkovic L.,University of Zagreb
Materialwissenschaft und Werkstofftechnik | Year: 2013

The aim of this work was to identify and characterize three samples of jarosite process tailing waste in Mitrovica, Kosovo, using Raman and Fourier transform infrared (FTIR) spectroscopy. The identification is made based on the assignment of bands in the Raman and FTIR spectra. Both Raman and FTIR spectra show the fundamental stretching and bending vibration mode of SO 4 2-, OH- and NH4 + groups. The results obtained by the means of Raman and infrared spectroscopy are compared with cited reference data in order to sum the analysis of vibrational spectra. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Curkovic L.,University of Zagreb | Ljubas D.,University of Zagreb | Segota S.,Ruder Boskovic Institute | Bacic I.,Forensic Science Center Ivan Vucetic
Journal of Alloys and Compounds | Year: 2014

Nanostructured sol-gel TiO2 films were prepared on a glass substrate by means of the dip-coating technique with titanium tetraisopropoxide as a precursor. TiO2 sols were synthesized with and without the addition of polyethylene glycol (PEG) as a structure-directing agent. The synthesized sol-gel TiO2 were characterized by XRD, AFM, FTIR and Micro-Raman spectroscopy. The photocatalytic activity of the films was evaluated by the photocatalytic degradation of Lissamine Green B (LGB) dye (dissolved in water) as a model pollutant with the predominant irradiation wavelength of 365 nm (UV-A). It was found that the addition of PEG to the initial sol affects the surface morphology and the photocatalytic properties of prepared sol-gel TiO2 films. AFM analysis confirmed the presence of nanostructured sol-gel titania films on the glass substrate. Roughness parameters (R a, Rq, and Zmax) of the sol-gel TiO2 film with the addition of PEG are higher than the parameters of the sol-gel TiO2 film without the addition of PEG. The TiO2 film prepared with the addition of PEG has a higher surface density (a larger active surface area) and better photocatalytic activity in the degradation of the LGB dye solution than the TiO2 film prepared without the addition of PEG. © 2014 Elsevier B.V. All rights reserved.

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