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Cincinnati, OH, United States

Lanzarotta A.,Forensic Chemistry Center
Sensors (Switzerland)

A search of the current scientific literature yields a limited number of studies that describe the use of Fourier transform infrared (FT-IR) spectroscopic imaging for the analysis of forensic casework, which is likely due to the fact that these instruments are fairly new commodities to the field of analytical chemistry and are therefore not yet commonplace in forensic laboratories. This report describes recent forensic case studies that have used the technique for determining the composition of a wide variety of multi-component sample types, including animal tissue sections for toxic inclusions, drugs/dietary supplements, an antibiotic with an active pharmaceutical ingredient (API) present as several different salt forms, an adulterated bulk API, unknown trace powders for illicit drugs and an ophthalmic solution suspected of being adulterated with bleach. © 2016 by the authors; licensee MDPI, Basel, Switzerland. Source

Lanzarotta A.,Forensic Chemistry Center | Lakes K.,Miami University Ohio | Witkowski M.R.,Forensic Chemistry Center | Sommer A.J.,Miami University Ohio
Analytical Chemistry

Advantages and limitations of analyzing authentic and counterfeit pharmaceutical tablets with both macro (nonimaging) attenuated total internal reflection Fourier transform infrared (ATR-FT-IR) spectroscopy and micro ATR-FT-IR spectroscopic imaging have been evaluated. The results of this study demonstrated that micro ATR imaging was more effective for extracting formulation information (sourcing), whereas a macro ATR approach was better suited for counterfeit detection (screening). More importantly, this study demonstrated that a thorough analysis of the counterfeit core can be achieved by combining the results of both techniques. © 2011 American Chemical Society. Source

Easter R.,University of Cincinnati | Easter R.,Forensic Chemistry Center | Barry C.,Forensic Chemistry Center | Caruso J.,University of Cincinnati | Limbach P.,University of Cincinnati
Analytical Methods

A combined hydrophilic interaction chromatography (HILIC) electrospray ionization mass spectrometry (ESI-MS) approach for the separation and identification of phosphorothioate oligonucleotides is described. Phosphorothioate 21-mer and 23-mer were separated by HILIC and detected using selected ion monitoring (SIM) ESI-MS. Phosphorothioates could be detected from 50 nM solutions suggesting effectiveness comparable to ion pairing reversed phase chromatography approaches. © 2013 The Royal Society of Chemistry. Source

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