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Wu H.-C.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Yang S.-C.,Kaohsiung Medical University | And 4 more authors.
Phytochemistry | Year: 2012

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively. © 2012 Elsevier Ltd. All rights reserved. Source


Chen J.-J.,Tajen University | Huang S.-S.,Tajen University | Liao C.-H.,Chang Gung University | Wei D.-C.,Tajen University | And 3 more authors.
Food Chemistry | Year: 2010

The fruit of Swietenia macrophylla is commercially used in healthcare products for the improvement of blood circulation and skin condition. A new phragmalin-type limonoid, 6-O-acetyl-3′-demethylswietephragmin E (1), has been isolated from the fruit of S. macrophylla, together with 16 known compounds. The structure of this new compound was determined through spectroscopic and MS analyses. 6-O-Acetyl-3′-demethylswietephragmin E (1), 3,6-O,O-diacetylswietenolide (5), 3-O-tigloylswietenolide (6), 3-O-tigloyl-6-O-acetylswietenolide (8), swietemahonin E (9), and 6-O-acetylswietemahonin G (10) exhibited inhibition (IC50 ≤ 35.7 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP). © 2009 Elsevier Ltd. All rights reserved. Source


Chen L.-W.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2010

Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumiso-flavone (9) genistein (10), 2′-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6β-hydroxystigmast-4-en-3-one (20) and 6β-hydroxystigmasta-4,22- dien-3-one (21), and a mixture of β-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H 37R V in vitro with MIC values of 16, 35, 30, and ≤2.8 μg/ml, respectively. © 2010 Verlag Helvetica Chimica Acta AG. Source


Chiang C.-C.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Huang H.-Y.,Kaohsiung Medical University | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2010

One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2-14, scopoletin (3), isobavachalcone (12), and (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl) phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)prop-2-en-1-one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H 37Rv, with MIC values of 42, 18, and 30 μg/ml, respectively. © 2010 Verlag Helvetica Chimica Acta AG. Source


Chou T.-H.,Kaohsiung Medical University | Chen J.-J.,Tajen University | Peng C.-F.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2011

Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H 37Rv strain in vitro with MIC values of 3.5 and 25.0μg/ml, respectively. © 2011 Verlag Helvetica Chimica Acta AG, Zürich. Source

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