Food Industry Research and Development Institute FIRDI

Hsinchu, Taiwan

Food Industry Research and Development Institute FIRDI

Hsinchu, Taiwan
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Chen J.-J.,Tajen University | Huang S.-S.,Tajen University | Liao C.-H.,Chang Gung University | Wei D.-C.,Tajen University | And 3 more authors.
Food Chemistry | Year: 2010

The fruit of Swietenia macrophylla is commercially used in healthcare products for the improvement of blood circulation and skin condition. A new phragmalin-type limonoid, 6-O-acetyl-3′-demethylswietephragmin E (1), has been isolated from the fruit of S. macrophylla, together with 16 known compounds. The structure of this new compound was determined through spectroscopic and MS analyses. 6-O-Acetyl-3′-demethylswietephragmin E (1), 3,6-O,O-diacetylswietenolide (5), 3-O-tigloylswietenolide (6), 3-O-tigloyl-6-O-acetylswietenolide (8), swietemahonin E (9), and 6-O-acetylswietemahonin G (10) exhibited inhibition (IC50 ≤ 35.7 μM) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP). © 2009 Elsevier Ltd. All rights reserved.


Wu H.-C.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Yang S.-C.,Kaohsiung Medical University | And 4 more authors.
Phytochemistry | Year: 2012

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively. © 2012 Elsevier Ltd. All rights reserved.


Chiang C.-C.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Huang H.-Y.,Kaohsiung Medical University | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2010

One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2-14, scopoletin (3), isobavachalcone (12), and (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl) phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)prop-2-en-1-one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H 37Rv, with MIC values of 42, 18, and 30 μg/ml, respectively. © 2010 Verlag Helvetica Chimica Acta AG.


Chen L.-W.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Peng C.-F.,Kaohsiung Medical University | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2010

Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumiso-flavone (9) genistein (10), 2′-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6β-hydroxystigmast-4-en-3-one (20) and 6β-hydroxystigmasta-4,22- dien-3-one (21), and a mixture of β-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H 37R V in vitro with MIC values of 16, 35, 30, and ≤2.8 μg/ml, respectively. © 2010 Verlag Helvetica Chimica Acta AG.


Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Wu M.-D.,Food Industry Research and Development Institute FIRDI | Chen I.-S.,Kaohsiung Medical University | Yuan G.-F.,Food Industry Research and Development Institute FIRDI
Natural Product Research | Year: 2010

A new sesquiterpene, monaspilosuslin (1), as well as seven known compounds 3β-hydroxystigmast-5-en-7-one (2), β-sitostenone (3), monascin (4), ankaflavin (5), N-trans-feruloyltyramine (6), vanillic acid (7) and -tocopheryl quinone (8), were isolated from the n-BuOH-soluble fraction of the 70% ethanolic extract of red yeast rice fermented with the fungus Monascus pilosus BCRC 38072 (Eurotiaceae). The structures of these compounds were determined by analyses of spectroscopic data, mainly 2D nuclear magnetic resonance (NMR) experiments. All of the isolates were also evaluated for their scavenging properties toward the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical in thin layer chromatography (TLC) autographic and spectroscopic methods. © 2010 Taylor & Francis.


Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Yeh Y.-T.,Fooyin University | Wang C.-J.,Kaohsiung Medical University | Chen C.-Y.,Fooyin University
Natural Product Research | Year: 2011

Investigation of leaf extract of Cinnamomum tenuifolium (Lauraceae) led to the isolation of one new nitrobenzoate, ethyl 3,5-dihydroxy-4-nitrobenzoate (1), along with four known compounds. This is the first report of Cinnamomum metabolites with a nitro benzenoid derivative. Their structures were determined through in-depth spectroscopic and mass spectrometric analyses. © 2011 Taylor & Francis.


Chou T.-H.,Kaohsiung Medical University | Chen J.-J.,Tajen University | Peng C.-F.,Kaohsiung Medical University | Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Chen I.-S.,Kaohsiung Medical University
Chemistry and Biodiversity | Year: 2011

Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H 37Rv strain in vitro with MIC values of 3.5 and 25.0μg/ml, respectively. © 2011 Verlag Helvetica Chimica Acta AG, Zürich.


Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Wu M.-D.,Food Industry Research and Development Institute FIRDI | Yuan G.-F.,Food Industry Research and Development Institute FIRDI | Su Y.-S.,Kaohsiung Medical University | Yanai H.,Kino Dental Clinical
Phytochemistry Letters | Year: 2012

A detailed phytochemical study of the n-BuOH-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus pilosus BCRC 38072 (Eurotiaceae) revealed a new azaphilone derivative, namely monascusazaphilol (1) (rel-(3S,3aR,9aR)-3-(1-hydroxydecyl)-9a-methyl-6-((E)- propenyl)-3a,4,8,9a-tetrahydro-3H-furo[3,2-g]isochromene-2,9-dione), along with ten known compounds (2-11). Their structures were established by direct interpretation of their spectral data, mainly high resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D and 2D NMR (COSY, ROESY, HSQC and HMBC), and comparison of the spectroscopic data with those reported for structurally related compounds. We also evaluated the inhibitory effects of some isolates on the production of tumor necrosis factor (TNF-α) induced by lipopolysaccharide (LPS). Among the isolates, compounds 1-3 inhibited TNF-α production in U937 cells in vitro, and the IC 50 values were 1.24, 2.35 and 3.75 μg/ml, respectively. © 2012 Phytochemical Society of Europe.


Cheng M.-J.,Food Industry Research and Development Institute FIRDI | Wu M.-D.,Food Industry Research and Development Institute FIRDI | Su Y.-S.,Kaohsiung Medical University | Yuan G.-F.,Food Industry Research and Development Institute FIRDI | And 2 more authors.
Phytochemistry Letters | Year: 2012

Phytochemical analysis of the n-BuOH-soluble fraction of the 95% EtOH extract of the red yeast rice fermented with the yellow mutant of the fungus Monascus kaoliang BCRC 31506 led to the isolation of one new azaphilone metabolite, designated as monascuskaolin (1), along with 9 known compounds (2-10). Monascuskaolin (1) contains an isochroman-6-one azaphilone skeleton connected with one γ-lactone ring, one propan-2-yl acetate moiety, and one decanoyl side chain. Their structures were elucidated by detailed spectroscopic analyses, including HRESIMS and 1D and 2D NMR data (COSY, HSQC, HMBC, and NOESY). The relative configuration of 1 was confirmed by NOESY experiment. Other known compounds were identified by comparison of their spectral data with the literature data of authentic samples. Inhibitory effects of some isolates on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages were evaluated. Compounds 1-4 showed inhibition on NO production in LPS-stimulated RAW 264.7 macrophages in vitro, showing MIC values of 7.62, 18.78, 26.72, and 32.80 μg/mL, respectively. © 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.


Wei Y.-H.,Food Industry Research and Development Institute FIRDI | Liou G.-Y.,Food Industry Research and Development Institute FIRDI | Liu H.-Y.,Food Industry Research and Development Institute FIRDI | Lee F.-L.,Food Industry Research and Development Institute FIRDI
International Journal of Systematic and Evolutionary Microbiology | Year: 2011

Three ustilaginomycetous anamorphic strains were isolated from flowers of Kandelia candel in mangrove forests of Taiwan. Phylogenetic analyses based on the combined sequences of internal transcribed spacer 1 (ITS1)-5.8S-ITS2 and the D1/D2 domain of the large-subunit (LSU) rDNA indicated that the closest recognized species was Sympodiomycopsis paphiopedili. The results of a DNA-DNA hybridization experiment and the physiological characteristics showed that the three strains represent a novel species within the genus Sympodiomycopsis. The name Sympodiomycopsis kandeliae sp. nov. is proposed, with FIRDI 007T (=BCRC 23165T =CBS 11676T) as the type strain. In addition, based on phenotypic characteristics and the phylogenetic analyses of the combined sequences of the ITS region and D1/D2 domain of the LSU rDNA, Sympodiomycopsis lanaiensis was clustered with the genus Jaminaea. A new combination, Jaminaea lanaiensis comb. nov. (type strain LM418T =DSM 18755T =ATCC MYA-4092T =NRRL Y-48466T =CBS 10858T =BCRC 23177T), is proposed. © 2011 IUMS.

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