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Nadri H.,Tehran University of Medical Sciences | Pirali-Hamedani M.,Tehran University of Medical Sciences | Shekarchi M.,Food and Drug Control Laboratories Research Center | Abdollahi M.,Tehran University of Medical Sciences | And 5 more authors.
Bioorganic and Medicinal Chemistry | Year: 2010

A novel series of benzofuranone-ylidene-methyl benzylpyridinium derivatives (6a-u) were synthesized as acetylcholinesterase inhibitors. The anticholinesterase activity of synthesized compounds was measured using colorimetric Ellman's method. It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among them compound 6b was the most active compound (IC50 = 10 ± 6.87 nM). © 2010 Elsevier Ltd. All rights reserved.

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