Food and Drug Control Laboratories FDCLs

Tehrān, Iran

Food and Drug Control Laboratories FDCLs

Tehrān, Iran
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Mousavi Khaneghah A.,Islamic Azad University at Tehran | Mousavi Khaneghah A.,University of Campinas | Shoeibi S.,Food and Drug Control Laboratories FDCLs | Limbo S.,University of Milan | And 2 more authors.
International Food Research Journal | Year: 2015

Overall migration (OM) of polyethylene terephthalate (PET) pieces into three types of commercial oils, namely sunflower oil, canola oil and blended oil (which included sunflower oil, soybean oil, and cottonseed oil) has been investigated by the determination of the weight variation of plastic pieces before and after 20, 60 days contact with oil at 25, 45°C and also determination the amount of absorbed oil. Also Fatty acid profiles of each type of oil were determined by using a Gas Chromatography (GC) system before and after experiments to find the correlation between the amount of overall migration and fatty acid profile. The result shows that the highest migration level was noticed with PET pieces contacted with blended oil. Also the effect of temperature, storage time, kind of oils and amount of unsaturated fatty acids and degree of unsaturation in amount of migration were observed. The amount of migration has correlation with fatty acid profile, especially the amount of unsaturated fatty acids and also, the degree of unsaturation. The reasons of these subjects can be investigated in future trends. Previous investigations have been performed on food stimulant such as olive oil and synthetic triglyceric mixture HB307, the present study has the advantage of working on real food samples so obtaining more accurate results were possible.


Rahimifard N.,Food and Drug Laboratory Research Center | Rahimifard N.,Food and Drug Control Laboratories FDCLs | Rahimifard N.,Islamic Azad University at Tehran | Hajimehdipoor H.,Shahid Beheshti University of Medical Sciences | And 4 more authors.
Journal of Medicinal Plants | Year: 2010

Background: Mentha species are widely used in traditional medicine mostly as anti-flatulence. Nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. Moreover, cytotoxic effects of some Mentha species have been reported. Objective: In this study, cytotoxic properties of Mentha piperita, M. spicata, M. aquatica, M. crispa, M. pulegium and M. longifolia have been investigated. Methods: Different concentrations of essential oils and total extracts of six Mentha species were tested by MTT assay against Vero, Hep2 and Hela cell lines. Results: The results showed that all samples were toxic against Vero, Hela and Hep2 cell lines (IC50 28.1-166.2 μg/ml). Conclusion: All examined Mentha species extracts and essential oils have cytotoxic effects but some of them could be considered as potent toxic agents.


Aminnezhad S.,Islamic Azad University at Dāmghān | Rahimifard N.,Food and Drug Laboratory Research Center | Rahimifard N.,Food and Drug Control Laboratories FDCLs | Kermanshahi R.K.,Alzahra University | And 3 more authors.
Biosciences Biotechnology Research Asia | Year: 2012

Antimicrobial resistance development resulted by using of antibiotics in treatment of infectious diseases. Therefore, there is a big demand for new sources of treatment again such as using of drug. In The other hand reduce antibiotic dose required to decrease the associated side effect. In this study the synergistic action of Conventional Antibiotics and cell free supernatant (CFS) of probiotic (L. plantarum ATCC:8014) against P. aeruginosa ATCC: 27853was evaluated. Cultured medium of probiotic bacteria were separated by centrifuging at 15000 rpm. The antimicrobial effects CFS of L. plantarum was evaluated by well diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by micro dilution method according to CLSI 2006. Finally interaction between CFS and Amikacin, Gentamicin, Ciprofloxacin and Azithromycin against P. aeruginosa ATCC: 27853 were examined through checkerboard method and fractional inhibitory concentration (FIC) was determined. The results showed a significant effect by CFS on the P. aeruginosa. The MIC and MBC of CFS from L. plantarum were 62.5 ìID ml and 125/μlD ml. Using the FIC indices, synergistic interactions were observed in combination of CFS and antibiotics. FIC indices of CFS from L. plantarum and Gentamicin, and Azithromycin were 0.124 and 0.312 respectively showing synergism effect, while FIC indices of CFS and Amikacin and Ciprofloxacin were 1.6 and demonstrated indifference action. Our finding indicated that L. plantarum as probiotic bacteria have a significant inhibitory effect on the growth of Pseudomonas aeruginosa ATCC: 27853. The antimicrobial potency of this combination can be useful for designing and developing alternative therapeutic strategies again P. aeruginosa infections.


Mousavi Khaneghah A.,Islamic Azad University at Tehran | Limbo S.,University of Milan | Shoeibi S.,Food and Drug Control Laboratories FDCLs | Mazinani S.,Islamic Azad University
Journal of the Science of Food and Agriculture | Year: 2014

BACKGROUND: Polyethylene terephthalate (PET) containers for food oil packaging were evaluated with a newly established determination method for terephthalic acid (TPA) and isophthalic acid (IPA). The analysis of monomers, TPA and IPA that migrate from PET bottles into oils was performed using high-pressure liquid chromatography with a diode array detector. Three types of commercial oils (sunflower oil, canola oil and blended oil which included sunflower oil, soy bean oil and cottonseed oil) were bottled in PET containers. These samples were incubated for 10 days at 49 °C as accelerated test condition. RESULTS: The means of recovery for this method varied from 70% to 72% and from 101% to 111% for TPA and IPA, respectively. The results showed that the amounts of specific migration of TPA and IPA into the samples conform to European Union legislation that identifies specific migration limits. More important, the results highlighted a different behavior of migration as a function of the fatty acid profile. CONCLUSION: Previous investigations have been performed with food simulants such as HB307 or 20% ethanol but our study used real food samples and determined trace amounts of the migrated compounds. Further investigation will be needed to better explain the influence of fatty acid conformation on migration of PET monomers. © 2013 Society of Chemical Industry.


Khaneghah A.M.,Islamic Azad University at Tehran | Shoeibi S.,Food and Drug Control Laboratories FDCLs | Ameri M.,Savola Behshahr Ind Co
Advances in Environmental Biology | Year: 2012

The Effects of polyethylene terephthalate (PET) pieces and different storage conditions on fatty acids profile and some quality factors in three types of commercial oils, namely sunflower oil, canola oil, and blended oil containing sunflower oil, soy bean oil, and cottonseed oil were studied. Fatty acid profile and quality factors such as peroxide value, free fatty acids, and iodine value and induction period before and after storage of samples at 25 and 45°C for 20 and 60 days in the presence or absence of PET pieces were investigated. Results showed that the amount of polyunsaturated fatty acids like linoleic acid was decreased slightly and the amount of monounsaturated and saturated fatty acids like oleic acid and palmitic acid, respectively, was marginally increased. Thus, it was concluded that the stability of vegetable oils is dependent on the type of oil and its initial physical and chemical properties, time and temperature of storage and the type of employed packaging material (PET and glass). This study showed that storing oils at low temperatures (T<25 °C) may be recommended in order to extend the shelf life and maintenance quality of commercial oils which are packaged in PET containers.


Karami F.,Islamic Azad University at Tehran | Omrani G.A.,Islamic Azad University at Tehran | Shoeibi S.,Food and Drug Control Laboratories FDCLs | Ranjbar R.,Baqiyatallah Medical Sciences University | And 3 more authors.
Journal of Isfahan Medical School | Year: 2014

Background: Many species of sustainable mycotoxin-producing fungi are considered as dangerous agents for humans. Bread is one of the materials exposed to fungal infection and molds are amongst the most important pollutant microbial and chemical mycotoxin-producing agents of bread. In this study, the microbial and chemical contamination of recycled waste breads and the types of produced mycotoxins at two areas of Tehran municipality, Iran, were investigated. Methods: Using fungal culture media, twenty samples of waste bread were analyzed for microbial contaminations. To recognize contamination to mycotoxins, high-performance liquid chromatography (HPLC) method and fuorescence detector (FLD) were used. Findings: All but one sample were contaminated to mold infections such as Aspergillus, Penicillium, and yeasts including Geotricum candidum, Candidia albicans and Saccharomyces cerevisiae. Eight samples were contaminated to aflatoxins, ochratoxin A and deoxynivalenol, whereas none of them showed contamination with zearalenone. Conclusion: The results indicated that presence of microbial and toxic contamination in bread waste is inevitable, which is harmful for human health. The sanitary control of food waste to reduce or eliminate microbial hazards in food recycling is necessary. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.


Sajadian S.S.,Islamic Azad University at Varamin | Khosrokhavar R.,Food and Drug Laboratory Research Center | Eshaghi M.R.,Islamic Azad University at Varamin | Shahrestani M.,Food and Drug Control Laboratories FDCLs | And 3 more authors.
CEFood 2012 - Proceedings of 6th Central European Congress on Food | Year: 2012

Bisphenol A diglycidyl ether (BADGE) and its derivatives are determined in canned oily foods from Iran's market using a new simplified extraction method. Samples are extracted with methanol, back extracted with methanol, and were analyzed by using reversed-phase high performance liquid chromatography (RP-HPLC) with fluorescence detection (FLD) and excellent validation data were obtained. Whereas detection limit for BADGE.2H2O was detected in 0.04 ppm. Also the present of recovery for BADE and its derivatives in comparison to previous investigations is suitable. This method can detect the amount of BADGE and its derivatives in low concentration. From 57 analyzed cans, containing various fatty tuna fish products, BADGE.HCL, BADGE.H2O.HCL and BADGE.H2O were not detected in any samples. However, BADGE, BADGE.2H2O and BADGE.2HCL were detected in samples but the amounts of specific migration of BADGE and its derivatives from metal cans into the samples conform to European Community legislation (EC 1895/2005 that determined specific migration limits (SML) for sum of the BADGE and its hydrolyzed derivatives is 9 mg/kg and Sum of chlorinated derivatives is, 1 mg/kg), which confirm the safety of these cans container that were used for packaging oily foods in Iran.


Ronaghi A.A.,Islamic Azad University at Varamin | Khosrokhavar R.,Food and Drug Laboratory Research Center | Eshaghi M.R.,Islamic Azad University at Varamin | Shahrestani M.,Food and Drug Control Laboratories FDCLs | And 3 more authors.
CEFood 2012 - Proceedings of 6th Central European Congress on Food | Year: 2012

Metal cans as an economic and useful packaging usually have a polymeric coating, and it is possible that different compounds can transfer from this coating to foodstuff. If this transferring includes known and unknown compounds, it will be known as Overall migration. In this study overall migration caused by metal can polymeric coatings in food stimulants, is investigated. Investigated metal can lacquer coatings, were from golden phenolic epoxy kind, beige phenolic epoxy kind, and white Andric epoxy kind, and 10% ethanol and 3% acetic acid was used as stimulant for overall migration testing. The Overall migration was calculated by determination the lose weight of lacquers after storage at mentioned conditions. Result showed that overall migration ranges obtained from golden phenolic epoxy, beige phenolic epoxy, and white Andric epoxy liquors are around 2-4.2 mg/dm2, 1.65-4.9 mg/dm2, 2-4.2 mg/dm2, respectively. Results show that the amounts of overall are adopted with (European Union) EU legislation that identifies as overall migration limit (OML).


Sajadian S.S.,Islamic Azad University at Varamin | Shoeibi S.,Food and Drug Control Laboratories FDCLs | Eshaghi M.R.,Islamic Azad University at Varamin | Shahrestani M.,Food and Drug Control Laboratories FDCLs | Mousavi Khaneghah A.,Middle East Technical University
Advances in Environmental Biology | Year: 2012

Migration of compounds from packaging materials is one of the most important aspects of food safety. The main purpose of this study is determination and quantification of migrated BADGE and its derivatives in canned tuna fishes by a rapid HPLC (High Performance Liquid Chromatography) method with fluorescence detector. Samples have been collected from Iran's market by PMS method (Post Marketing Service) from different regions of Iran. Migrated compounds were extracted with methanol then analyzed by a HPLC system. This method can detect the amount of BADGE and its derivatives in low concentration. Whereas detection limit for BADGE.2H2O was detected in 0.04 ppm. Also the present of recovery for BADE and its derivatives in comparison to previous investigations is suitable. Results showed that the BADGE.HCL, BADGE.H2O.HCL and BADGE.H2O were not detected in any samples. However, BADGE, BADGE.2H2O and BADGE.2HCL were detected in samples but the amounts of specific migration of BADGE and its derivatives from metal cans into the samples conform to EU legislation (EC 1895/2005 that determined specific migration limits (SML) for sum of the BADGE and its hydrolyzed derivatives is 9 mg/kg and Sum of chlorinated derivatives is, 1 mg/kg), which confirm the safety of these cans container that were used for packaging of tuna fish in Iran's market.


Rahimifard N.,Food and Drug Laboratory Research Center | Rahimifard N.,Food and Drug Control Laboratories FDCLs | Rabiei M.,Food and Drug Laboratory Research Center | Rabiei M.,Food and Drug Control Laboratories FDCLs | And 2 more authors.
Biosciences Biotechnology Research Asia | Year: 2012

Helicobacter pylori, a gram negative microaerophilic bacterium, infection is now recognised as a worldwide problem. The growing problem of antibiotic resistance by the organism demands the search for novel herbal compounds. The present study is designed for evaluating the antimicrobial effect of methanol extract of this remedy on clinical isolates of H.pylori in Kashan to identify potential sources of cheap stating materials for the synthesis of new and more effective drugs. This study was taken from 20 Helicobacter pylori samples isolated from patients with gastrointestinal disorders. The samples were cultured on Columbia agar base plates (Merck) with supplements. Plates were incubated at 37°C for 3-5 days in a microaerophilic environment (anaerocult C, Merck). The isolates that grown on plates were identified by bacteriological tests. The micro dilution broth method was used to determine the susceptibility of methanol extract of ginger on 20 isolates of H.pylori with a serial dilution of 1000, 500, 250, 50, 25, 12.5, 6.25, 3.125, 1.56, 0.78 μg/ml. The MIC of extract ranged from 3.125-25 μg/ml for H.pylori, the MIC of 12 (60%) isolates were 3.125μg/ml ,4 isolates(20%)were 12.5μg/ml, 3 isolates(15%)were 6.25/xg/ml, 1 isolate (5%)was 25μg/ml. The methanolic extract of ginger may contain compounds with therapeutic activity, and the most effective MIC (60%) against H.pylori were 3.125μg/ml. We also understand that H.pylori has high sensivity against ginger.

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