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Shakouri A.,Shahid Beheshti University of Medical Sciences | Yazdanpanah H.,Shahid Beheshti University of Medical Sciences | Yazdanpanah H.,Food and Drug Control Laboratories | Shojaee M.H.,Faroogh Life science Research Laboratory | Kobarfard F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Pharmaceutical Research | Year: 2014

A multi-residue method for simultaneous determination of 41 LC-amenable pesticides in rice, belonging to different chemical classes has been developed in Iran by LC-MS/MS. For the first time the pesticides were analyzed simultaneously in a single run using positive electrospray ionization with multiple reaction monitoring (MRM) after extraction with slightly modified QuEChERS method. The calibration curve for each analyte was linear over the concentration range of 0.02-1.0 μg/g with a correlation coefficient range between 0.993 and 0.999. The LOQ and LOD were.025 μg/g and 0.008 μg/g respectively, for all 41 pesticides and the mean recoveries obtained for three fortification levels (0.025, 0.08 and 0.250 μg/g) were 71-119% with satisfactory precision (RSD<20%). The developed method was used to investigate the occurrence of pesticides in 30 domestic and 30 imported rice samples collected from Tehran market. Five compounds were detected in 11 domestic and 9 imported positive samples in concentration range from 0.032 μg/g to 0.081 μg/g and 0.028 μg/g to 0.074 μg/g, respectively. With the exception of prohibited pesticides, phosphamidon and TCMTB, three permitted pesticides, cinosulfuron, triadimenol and tricyclazole, found in positive rice samples were below MRLs established by Institute of Standards and Industrial Research of Iran (ISIRI). © 2014 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Peymani P.,Shiraz University of Medical Sciences | Joulaie H.,Shiraz University of Medical Sciences | Zamiri N.,Shiraz University of Medical Sciences | Ahmadi S.M.,Shiraz University of Medical Sciences | And 3 more authors.
Middle East Journal of Scientific Research | Year: 2012

Human intervention trials have documented that diets with high Trans Fatty Acids have significant adverse effects on cardiovascular disease (CVD). It seems reasonable for health sector policy makers to confront this serious and yet modifiable risk factor for CVD by focusing on oil industries responsible for TFA's production. Health policy makers are encouraged and designed a national plan and agenda in order to reduce the level and amount of TFAs in oil industry. The program's framework comprised three main aspects: Campaigning on Public education with an emphasis on increase in knowledge and attitude of the public regarding adverse health effects of TFA, negotiation of Ministry of Health and Medical Education (MOHME) representatives with food and oil processing companies and setting regulations on restricting the amount of TFAs from >20% to less than 10% and establishment of a national committee including experts of MOHME and representatives of major food industries to coordinate all policy makings on food production at national and local levels. Four years after implementation of the policy on limiting the amount of TFA in edible oil to 10%, a dramatic decline was observed in TFA content of edible oils in Iran from 28.8% in 2001 to 5.62% in 2006. TFA and SFA?? intake can be decreased by proper education, voluntary reduction of TFA content by oil industries and labeling of TFA and SFA (Saturated Fatty Acid) composition of each production along with legislations on TFA and SFA reduction in edible oil (legislation to ban these fats). Public campaigns and policy measures are motivating food manufacturers and restaurants to replace the trans fatty acids in foods with alternative fats. © IDOSI Publications, 2012.

Shoeibi S.,Food and Drug Control Laboratories | Shoeibi S.,Food and Drug Laboratories Research Center | Amirahmadi M.,Food and Drug Control Laboratories | Amirahmadi M.,Food and Drug Laboratories Research Center | And 6 more authors.
Iranian Journal of Pharmaceutical Research | Year: 2011

A gas chromatography mass spectrometry with spike calibration curve method was used to quantify three carbamate pesticides residue in cooked white rice and to estimate the reduction percentage of the cooking process duration. The selected pesticides are three carbamate pesticides including carbaryl and pirimicarb that their MRL is issued by "The Institute of Standards of Iran" and propoxur which is used as a widely consumed pesticide in rice. The analytical method entailed the following steps: 1- Blending 15 g cooked sample with 120 mL acetonitrile for 1 min in solvent proof blender, 2- Adding 6 g NaCl and blending for 1 min, 3- Filtering upper layer through 25 g anhydrous Na2SO4, 4- Cleaning up with PSA and MgSO4, 5- Centrifuging for 7 min, 6- Evaporating about 0.3 mL and reconstituting in toluene till 1 mL, 7- Injecting 2 μL extract into GC/MS and analyzing by single quadruple selected ion monitoring GC/MS-SQ-SIM. The concentration of pesticides and the percentage of pesticides amounts after the cooking were determined by gas chromatography mass-spectrometry (GC/MS) using with interpolation of the relative peak areas for each pesticide to internal standard peak area in the sample on the spiked calibration curve. Calibration curve was linear over the range of 25 to 1000 ng/g, and LOQ was 25 ng/g for all three pesticides. The percent of loss for the three pesticides were 78%, 55% and 35% for carbaryl, propoxur and pirimicarb respectively. Different parameters such as vapor pressure, boiling point, and suspect ability of the compound to hydrolysis, could be responsible for the losing of pesticides during the cooking process. © 2011 by School of Pharmacy.

Amirahmadi M.,Shahid Beheshti University of Medical Sciences | Amirahmadi M.,Food and Drug Laboratories Research Center | Amirahmadi M.,Food and Drug Control Laboratories | Yazdanpanah H.,Shahid Beheshti University of Medical Sciences | And 11 more authors.
Iranian Journal of Pharmaceutical Research | Year: 2013

A reliable, rapid and accurate method based on spiked calibration curves and direct sample introduction was developed for determination of 17 pesticide residues in rice by gas chromatography-mass spectrometry single quadrupole selected ion monitoring GC/MS-SQ-SIM. Sample preparation is based on extraction with acetonitrile without clean up. The use of spiked calibration curves for constructing the calibration curve substantially reduced adverse matrix-related effects. The average recovery of pesticides at 6 concentration levels was in range of 97.5-102.1%. The method was proved to be repeatable with RSDr in range of 0.7%-19.8%for all of the concentration levels. The limits of detection and limit of quantifications for all the pesticides were < 10 ng/g and < 25 ng/g, respectively. The developed method was applied for simultaneous determination of the selected pesticides in 23 rice samples collected from Tehran retail market in March 2009. Although many studies have been conducted regarding the determination of pesticides by using GC-MS, this is the first attempt in Iran using GC-MS-SIM technique that successfully can determine 17 pesticides with difference in physicochemical properties in rice. © 2013 by School of Pharmacy.

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