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Caliandro P.,Fondazione Don Carlo Gnocchi ONLUS
Cochrane database of systematic reviews (Online) | Year: 2011

Ulnar neuropathy at the elbow is the second most common entrapment neuropathy after carpal tunnel syndrome. Treatment may be conservative or surgical but optimal management remains controversial. The objectives of this systematic review were to determine the effectiveness and safety of conservative and surgical treatments in ulnar neuropathy at the elbow. We searched the Cochrane Neuromuscular Disease Group Specialized Register (16 February 2010), Cochrane Central Register of Controlled Trials (The Cochrane Library 2010, Issue 1), MEDLINE (January 1966 to February 2010), EMBASE (January 1980 to February 2010), AMED (January 1985 to February 2010), CINAHL Plus (January 1937 to February 2010), LILACS (January 1982 to Feburary 2010), PEDro (January 1980 to February 2010), and the papers cited in relevant reviews. The review included only randomised controlled clinical trials. Two authors independently reviewed titles and abstracts of references retrieved from the searches and selected all potentially relevant studies. The authors extracted data from included trials and assessed trial quality independently. They contacted trial investigators for missing information. We identified 1461 papers and selected six randomised controlled clinical trials with moderate quality evidence. The sequence generation was not adequate in one study and not described in two studies. We performed two meta-analyses to evaluate the clinical and neurophysiological outcomes of simple decompression versus decompression with submuscular or subcutaneous transposition.We found no difference between simple decompression and transposition of the ulnar nerve for both clinical improvement (risk ratio (RR) 0.93, 95% CI 0.80 to 1.08) and neurophysiological improvement (RR 1.47, 95% CI -0.94 to 3.87). Transposition showed a higher number of wound infections (RR 3.10, 95% CI 1.18 to 8.15).In one trial the authors compared medial epicondylectomy with anterior transposition and found no difference in the clinical and neurophysiological outcomes.One trial assessed conservative treatment in clinically mild or moderate ulnar neuropathy at the elbow. The authors found that information on avoiding prolonged movements or positions was effective in improving subjective discomfort. Night splinting and nerve gliding exercises in addition to the information did not produce further improvement. The available evidence is not sufficient to identify the best treatment for idiopathic ulnar neuropathy at the elbow on the basis of clinical, neurophysiological and imaging characteristics. We do not know when to treat a patient conservatively or surgically. However, the results of our meta-analysis suggest that simple decompression and decompression with transposition are equally effective in idiopathic ulnar neuropathy at the elbow, including when the nerve impairment is severe. In mild cases, evidence from one small randomised controlled trial of conservative treatment showed that information on movements or positions to avoid may reduce subjective discomfort. Source


Lagana M.M.,Fondazione Don Carlo Gnocchi ONLUS
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | Year: 2011

The Chronic Cerebro-Spinal Venous Insufficiency, recently described as a possible role in Multiple Sclerosis pathogenesis, is diagnosed and classified with Echo Color Doppler (ECD) examination of the extra- and intra-cranial veins. As to the intracranial examination, the presence of reflux in the deep cerebral veins (DCVs) or in the dural sinuses is inspected, with a new insonation approach, i.e. the transcondylar window. This work describes a procedure for the co-registration of anatomical Proton Density-weighted Magnetic Resonance Images (MRI) with the intracranial ECD obtained through the transcondylar window. The procedure, preliminarily tested on 10 volunteers, allowed to assess what are the DCVs visible from this new insonation approach and their position relative to the surrounding brain tissues. Source


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: HEALTH.2012.4.1-5 | Award Amount: 620.09K | Year: 2012

Nanotechnology applied to medical applications, Nanomedicine, is one of the most important emerging areas of health research and is understood to be the most promising out of the six KETs, for innovative devices and materials for personalised, targeted and regenerative medicine. However, due to the complexity of technologies and medical application areas Nanomedicine requires many different so far independent stakeholders from academia, industry and regulatory bodies. Due to the diversity of stakeholders the partners of this project will initiate a strong coordination and support action to build a pertinent European Nanomedicine community involving all key players necessary to define the resources, gaps and needs for development and implementation of nanomedical research into marketable innovations to be used by doctors for the benefit of patients. The implementation concepts will also target the initiation of Public Private Partnerships for the creation of novel infrastructures and innovative funding programmes. Nanomedicine research is growing fast in many countries. Therefore, the project consortium will initiate international collaborations in the Nanomedicine area, especially the coordination of international regulation of Nanomedicine products. The partners involved in the project represent major European networks combining academia, industry, clinicians and public authorities. Based on this strong partnership and after integration of further national and European initiatives the output of this support action will be a strong, established partnership of relevant stakeholders in identified key areas of Nanomedicine with new concepts for translation of nanomedical innovations into clinical practice and efficient and transparent communication channels. This will make Nanomedicine an important contributor to the future European healthcare system with a beneficial impact on improved treatment for patients and on social challenges such as ageing population.


Patent
Fondazione Don Carlo Gnocchi Onlus | Date: 2013-02-11

The present invention relates to a high voltage switch circuit, comprising an input port adapted to receive a pulse type input current and an output port, which can be used selectively to conduct an output current to a corresponding electrical load. The switch circuit comprises a buffer stage adapted to sense the input voltage at said input port and to provide a buffered voltage that follows said input voltage. The switch circuit comprises complementary switches electrically connected between said input port and said output port and a voltage level translator electrically connected with said switches, said buffer stage and a control terminal that provides a control signal. The voltage level translator provides suitable gate voltages at the gate terminals of said switches, so that the operation of these latter can be controlled by said control signal.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.5 | Award Amount: 12.98M | Year: 2011

As we move inextricably into a digital economy there is a looming crisis for a growing number of increasingly marginalized individuals. The accessibility technologies we have are meeting the needs of only some, at high cost, and will not work with many new technologies. The path and pace of technological change predestines these approaches to fail in the very near future. At the same time the incidence of disabilities is increasing as our population ages.\nThe same technical advances however hold the potential for a radical paradigm shift in our approach to accessibility that can harness the pace of innovation and have it work for us rather than against us. An international consortium is forming to tap the unprecedented ability to pool resources and match demand with supply enabled by the Cloud to build a Global Public Inclusive Infrastructure (GPII) that can deliver accessibility to every individual where they need it, when they need it and in a way that matches their unique requirements; automatically so that they do not need to negotiate, explain, qualify or justify.\nCloud4All represents a European based effort to advance the GPII concept by pulling together a large multi-sector international community including stakeholders, industry leaders and experts in emerging technologies to thoughtfully research, design, develop and test the key software infrastructure and pilot implementations needed to explore this promising approach to digital inclusion. Cloud4All will do this by:\n-Creating/refining user profiling standards and tools capable of capturing the individual needs and preferences of the full range of users facing interface barriers\n-Creating/refining interface and materials profiling standards and tools capable of characterizing the full range of ICT/materials users need to access and the different techniques and strategies for accessing them\n-Improving mechanisms to match users and with interfaces and materials they can use or techniques or services that can make them usable\n-Creating a mechanism to allow users to locate solutions from many different sources in a single search\n-Demonstrating automatic, on-demand, matching or modification of mainstream and specialized technologiesto match each individual as they encounter them, including proof-of-concept demonstrations of this approach across a spectrum of technologies including: Computer OSs and Browsers; Web pages/Apps; Mobiles; Kiosks/Info-Transaction Machines; Installed and Virtual Assistive Technologies; Digital Televisions and Smart Homes\n-Testing of the concept with users with a wide variety and combination of physical, sensory, cognitive, language, and learning disabilities\nIf successful, this approach may give us our first chance of reaching the large group of users that do not qualify for or otherwise have not been reached by special services, but nonetheless face barriers to access that prevent them from participating in our rapidly advancing digitally enabled society.

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