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Pedone C.,Biomedical University of Rome | Napoli N.,Fondazione Alberto Sordi ONLUS | Napoli N.,Biomedical University of Rome | Pozzilli P.,Fondazione Alberto Sordi ONLUS | And 6 more authors.
Journal of the American College of Nutrition | Year: 2011

Objective: Few data are available on the effect of the diet in general on bone health. The objective of this study was to identify dietary patterns and to evaluate the association between such patterns and bone mineral density (BMD) changes over time. Methods: We analyzed a sample of women aged ≥65 years participating in the InCHIANTI Study. BMD was evaluated using computed tomography of the tibia and nutritional intake using the EPIC questionnaire. We used a cluster analysis to identify patterns of dietary intake. The clusters were compared with respect to nutritional intake; risk factors for osteoporosis; comorbidity; total, trabecular, and cortical BMD; and BMD changes over 6 years. Results: The sample size was 434, with a mean age of 75.2 years (SD, 7.01 years; range, 65-94 years). Based on dietary variables, 2 clusters were identified with a marked difference in energy intake (30 kcal/kg of ideal body weight [IBW] in cluster 1 vs 44 kcal/kg IBW in cluster 2). We found no meaningful differences between clusters with regard to nondietary risk factors for osteoporosis, BMD measured at baseline, and changes in BMD over the 6-year follow-up; cluster 2 showed a greater increase in cortical BMD (+30.2 mg/cm 3 vs +16.7 mg/cm 3). Members of cluster 2 were less likely to have a lower cortical BMD increase (adjusted odds ratio, 0.452; 95% confidence interval, 0.215-0.950). Conclusions: Cortical BMD increases more in participants eating a diet exceeding the RDA for macronutrients. Cortical BMD may be more sensitive to diet and dietary interventions than trabecular bone. Source


Pedone C.,Biomedical University of Rome | Napoli N.,Fondazione Alberto Sordi ONLUS | Napoli N.,Biomedical University of Rome | Pozzilli P.,Fondazione Alberto Sordi ONLUS | And 5 more authors.
Bone | Year: 2010

Background: Bone mineral density (BMD) may be influenced by the general dietary pattern and the potential renal acid load (PRAL). Methods: We compared the dietary intake (estimated using the European Prospective Investigation into Cancer and nutrition questionnaire) of 497 community-living women (60 years of age and older) grouped according to tertiles of baseline total, trabecular and cortical BMD estimated using tibial peripheral quantitative computed tomography (pQCT), and of BMD variation over 6 years. Results: None of the nutrients taken into account nor PRAL was associated with total BMD, with the exception that the intake of polyunsaturated fatty acids (PUFA) was slightly higher among women with the highest total BMD. Similar results were found for trabecular BMD. Cortical BMD was associated with serum 25-OH vitamin D (38.8, 43.2, and 49.5 nmol/L in the first, second, and third tertiles, respectively; P=0.042). In the longitudinal analysis, a lower BMI was associated with greater loss of total BMD, while lower serum 25-OH vitamin D at baseline was associated with smaller loss of cortical BMD. Conclusions: We found no relationship between dietary acid load and BMD. We also confirmed the role of well-recognized risk factor for osteoporosis. © 2009 Elsevier Inc. Source

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