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Ceriani L.,Oncology Institute of Southern Switzerland | Martelli M.,University of Rome La Sapienza | Zinzani P.L.,Institute of Hematology and Medical Oncology | Ferreri A.J.M.,San Raffaele Scientific Institute | And 16 more authors.
Blood | Year: 2015

The International Extranodal Lymphoma Study Group (IELSG) 26 study was designed to evaluate the role of 18F-fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT) in the management of primary mediastinal (thymic) large B-cell lymphoma (PMBCL). We examined the prognostic impact of functional PET parameters at diagnosis. Metabolic activity defined by the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) was measured on baseline 18FDG PET/CT following a standard protocol in a prospectively enrolled cohort of 103 PMBCL patients. All received combination chemoimmunotherapy with doxorubicin- and rituximab-based regimens; 93 had consolidation radiotherapy. Cut-off values were determined using the receiver-operating characteristic curve. At a median follow-up of 36 months, progression-free survival (PFS) and overall survival (OS) were 87% and 94%, respectively. In univariate analysis, elevated MTV and TLG were significantly associated with worse PFS and OS. Only TLG retained statistical significance for both OS (P = .001) and PFS (P < .001) in multivariate analysis. At 5 years, OS was 100% for patients with low TLG vs 80% for those with high TLG (P = .0001), whereas PFS was 99% vs 64%, respectively (P < .0001). TLG on baseline PET appeared to be a powerful predictor of PMBCL outcomes and warrants further validation as a biomarker. The IELSG 26 study was registered at www.clinicaltrials.gov as #NCT00944567. © 2015 by The American Society of Hematology.

Pichiecchio A.,National Neurological Institute | Di Perri C.,National Neurological Institute | Arnoldi S.,National Neurological Institute | Berardinelli A.,University of Pavia | And 3 more authors.
Journal of Child Neurology | Year: 2011

Macrocerebellum, a neuroradiological and clinical entity of unknown etiology characterized by an isolated, disproportionately large cerebellum, has to date been reported in only a few cases. It has been suggested that the condition could represent a marker for disturbed cerebral development, however, longitudinal reports are lacking. We describe a 19-month-old patient with agenesis of the corpus callosum, who developed enlargement of the cerebellum without clinical signs of cerebellar impairment, a picture that has not been previously described. © The Author(s) 2011.

MIT President L. Rafael Reif and Gianfelice Rocca, chair of the Fondazione Fratelli Agostino ed Enrico Rocca, signed an agreement today renewing the Progetto Roberto Rocca, a two-way partnership between the Institute and Politecnico di Milano (POLIMI), Italy's top engineering school. Under the terms of the agreement, the Fondazione will provide $1.4 million to support a number of joint research projects, seminars, lectures, and other programming, including the MIT-Italy Program, through 2020. With this renewal, the Fondazione will have contributed $3.9 million over 15 years in support of the MIT-POLIMI partnership. The foundation honors the memory of MIT alumnus Roberto Rocca. According to President Reif, “MIT’s partnership with POLIMI has yielded wonderful opportunities for our faculty, postdocs, and students to collaborate with their counterparts in Italy in addressing common challenges in engineering and science. We remain grateful for the Fondazione’s continued commitment to creating such meaningful pathways for collaboration in problem-solving.” Gianfelice Rocca, the son of Roberto Rocca, and one of Italy’s leading industrialists, paid special tribute to MIT for establishing this program: "The Fondazione has been delighted to see such a robust and productive partnership develop between MIT and the Politecnico over the last decade, and looks forward to confirming its support to this initiative in the name of Roberto Rocca." An aspiration for the next five years is to build on the success of the first 10. With a focus on early-stage work — through supporting both promising young scholars and research projects in the start-up phase — the Progetto seeks to contribute to the emergence of the next generation of exceptional scientists and connect them with meaningful international experiences. Another major goal is to broaden and deepen the impact of these exchanges, in part by involving more faculty and students from both institutions. Since 2005, Progetto Rocca has facilitated more than 30 collaborations between MIT and POLIMI faculty and has funded nearly 100 doctoral and postdoctoral Rocca Fellows at each institution. Many of these collaborations have led to joint publications and have received other forms of academic recognition. The idea to strengthen interactions between MIT and POLIMI came from more than the institutions’ shared commitment to excellence in research and education. The Progetto is named in memory of Roberto Rocca ScD '51 (1922-2003), an alumnus of both institutions. Born in Milan and a graduate of the Politecnico di Milano, Roberto Rocca earned a ScD from MIT in materials science and engineering. The aims of the Progetto are in keeping with Roberto Rocca's passion for education, keen interest in scientific innovation, and his life and career building connections across the Atlantic. Supported activities also reflect Rocca’s fields of interest, including materials science and engineering, mechanical engineering, biological engineering and life sciences, electrical engineering, energy, and computer science.

Strahm B.,Albert Ludwigs University of Freiburg | Nollke P.,Albert Ludwigs University of Freiburg | Zecca M.,Fondazione | Korthof E.T.,Leiden University | And 18 more authors.
Leukemia | Year: 2011

We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan, cyclophosphamide and melphalan. Ninety-seven patients with refractory anemia with excess blasts (RAEB, n53), RAEB in transformation (RAEB-T, n29) and myelodysplasia-related acute myeloid leukemia (MDR-AML, n15) enrolled in the European Working Group of MDS in Childhood (EWOG-MDS) 98 study and given hematopoietic stem cell transplantation (HSCT) were analyzed. Median age at HSCT was 11.1 years (range 1.4-19.0). Thirty-nine children were transplanted from an MSD, whereas 58 were given the allograft from a UD (n57) or alternative family donor (n1). Stem cell source was bone marrow (n69) or peripheral blood (n28). With a median follow-up of 3.9 years (range 0.1-10.9), the 5-year probability of overall survival is 63%, while the 5-year cumulative incidence of transplantation-related mortality (TRM) and relapse is 21% each. Age at HSCT greater than 12 years, interval between diagnosis and HSCT longer than 4 months, and occurrence of acute or extensive chronic graft-versus-host disease were associated with increased TRM. The risk of relapse increased with more advanced disease. This study indicates that HSCT following a myeloablative preparative regimen offers a high probability of survival for children with advanced MDS. © 2011 Macmillan Publishers Limited All rights.

Simoes B.,Fondazione | Aksenov P.,TU Eindhoven | Santos P.,Fraunhofer Institute for Computer Graphics Research | Arentze T.,TU Eindhoven | De Amicis R.,Fondazione
2015 IEEE International Conference on Multimedia and Expo Workshops, ICMEW 2015 | Year: 2015

A key theme in ubiquitous computing is to create smart environments in which there is seamless integration of people, information, and physical reality. In this manuscript, we describe a set of tools that facilitate the creation of such environments, e,g, a service to transform videos recorded with mobile devices into navigable 3D scenes, a service to compute and describe the emotional processes that occur during the user interaction with such content, a service that takes into account certain dynamic needs of users in personalizing solutions for allocating their leisure time and activities, a gamified crowdsourcing application, and a set of projection-based tools for creating and interacting with augmented environments. Ultimately, our objective is have a framework that seamless integrates all these components, to foster creativity processes. © 2015 IEEE.

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