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Balaraju T.C.,Navodaya Medical College | Pathan R.,Navodaya Medical College | Thomas R.,Navodaya Medical College | Kantha S.,Navodaya Medical College | And 3 more authors.
Indian Journal of Public Health Research and Development | Year: 2013

Purpose: The objective of this study were to study the efficacy of dexmedetomidine as a sedative for endoscopic dacryocystorhinostomy performed under local anaesthesia compared to conventional sedative like midazolam and also to study the effects of dexmedetomidine on hemodynamic stability and analgesia. Methods: In this randomized, prospective double-blinded study 40 adult patients were allocated into two groups.Group D received dexmedetomidine 1μg/kg loading dose over 10 minutes followed by 0.5 μg/kg/hr maintenance dose and Group M received 20 μg/kg midazolam at the start of procedure plus same dose repeated 30 minutes later. Endoscopic dacryocystorhinostomy was performed in all patients under local anesthesia. Sedation was assessed using the modified Observer's Assessment Alertness/ Sedation (OAA/S) scale. Pulse rate(PR), Mean arterial pressure(MAP), oxygen saturation (SpO 2), respiratory rate (RR) were recorded every 5 minutes for first fifteen minute and then every ten minutes till the end of the procedure.In the post anaesthesia care unit, Aldrete score was determined every 5 minutes till the patient was ready for discharge Results: Pateints receiving dexmedetomidine had a better OAA/S score throughout the procedure and were more cooperative. VAS scores were significantly lower in the dexmedetomidine group.Pulse rate, MAP were lower in Group D whereas SpO 2 values were higher in Group D compared to Group M. Group D had lesser amount of bleeding but the time taken to reach an Aldrete score of 10 was similar between the groups. Conclusion: Dexmedetomidine is ideal for procedural sedation with the added benefit of hemodynamic stability, no respiratory depression and analgesia.

Basavaraj,Navodaya Medical College | Sreekantha,Navodaya Medical College | Shepur T.A.,Korea Institute of Materials Science | Nandi S.V.,Navodaya Medical College | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012

Objective: To study the prevalence of intestinal parasitic infestations in HIV seropositive children and to correlate these infestations with different immunological status and WHO clinical staging. Methods: Three consecutive samples of each 60 HIV seropositive children in the age group of 18 months to 15 years admitted in KIMS, Hubli, Karnataka, over a period of one year from 1st November2007 to 31st October 2008, were tested for intestinal parasites in the Microbiology department, KIMS, Hubli. Results: The overall prevalence of intestinal parasitic infestation found in this study was 35% (21/60 cases). Of 21 cases, 17 were seen in patients with severe immune suppression. Most of the intestinal parasitic infestations were seen in patients with diarrhea (16/28) cases compared to patients without diarrhea (5/32) cases. The most frequently detected intestinal parasite in this study was Balantidium Coli, followed by Ascaris lumbricoides, Trichuris trichura, Cryptosporidia, Hymenolepiasis nana, Strongyloides stercoralis, Enterobius vermicularis. One case of multiple intestinal parasitic infestations was also noted in this study. Conclusion: The present study highlights the magnitude of intestinal parasitic infestation HIV infected children. The prevalence was found to be significantly more in patients with diarrhea than without diarrhea. Most of the intestinal parasitic infestations were seen in severely immunosuppressed children. However, parasites were also observed in other immune suppression group. So intestinal parasitic infestation should be suspected in all HIV seropositive children particularly with diarrhea and severe immune suppression.

Palatty P.L.,FMMC | Saldanha E.,FMMC
Journal of Association of Physicians of India | Year: 2012

Weight management means lifestyle modification, behavioral therapy, pharmacotherapy and surgery. Drugs have wide ranging side effects and contraindication for its widespread use. Orlistat and sibutramine are the most popular in the present day context. Anti depressants especially fluoxetine is a valuable adjunct for therapy of obesity. There are many newer concepts in weight management and these are mainly hormonal and receptor based, thereby reducing the uncalled adverse effects of drugs like orlistat and sibutramine. Anti-obesity vaccine, an immunotherapy to be looked out for. © Japi.

Aramani A.,Nose and Throat | Karadi R.N.,Shri Bmpatil Medical College | Kumar S.,Fmmc
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Chronic rhino sinusitis(CRS) is the most common disease for which consultation of otorhinolaryngologist is sought. The approach to patients with chronic rhino sinusitis is endoscopic surgery which aims at removing the obstruction of the main drainage pathway. The osteomeatal complex based essentially on the concept that such obstruction perpetuates the sinus disease. This in turn requires the surgeons to have detailed knowledge of the anatomy of the lateral nasal wall, paranasal sinuses and surrounding vital structures and of the large number of anatomical variants in the region.Aims: To study anatomical variations of osteomeatal complex in chronic sinusitis patients.Materials and Methods: Descriptive Cross sectional study design in which fifty four consecutive cases of chronic rhino sinusitis patients attending the ENT outpatient department, who had chronic sinusitis for more than three months duration not responding to the medical line of treatment and who were willing to undergo Functional Endoscopic Sinus Surgery satisfying the inclusion criteria were studied. The results were expressed in percentage and proportions.Results: In our study it was observed that 53.7% of the chronic sinusitis cases had two or more anatomical variations and 33.3% of the cases had single anatomical variation. Deviated nasal septum was found to be the most common amongst the anatomical variations in chronic sinusitis cases in the present study which was followed by unilateral concha bullosa and paradoxically bent middle turbinate. Agger nasi cell and Haller cell were seen in one case each.Conclusion: Prevalence of multiple anatomical variations was more in our study in comparison to single anatomical variation. Deviated nasal septum was the most common anatomical variation encountered in our study followed by concha bullosa. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.

Balaraju T.C.,Navodaya Medical College | Ramdas B.,Navodaya Medical College | Thomas R.,Navodaya Medical College | Garg A.,Navodaya Medical College | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Aim: This randomized single blind study was designed to assess the effect of oral and intravenous (IV) clonidine premedication on hemodynamic response to endotracheal intubation, per-operative hemodynamic stability and post-operative analgesic requirements. Materials and Methods: In this randomised single blind study, 60 ASA grade I and grade 2 patients were randomized into two groups. Group O received 3+g/kg oral clonidine 2 hours prior to induction and group I received 3+g/kg iv clonidine 15 minutes prior to induction. Anaesthesia was induced with thiopentone and maintained with oxygen and nitrous oxide with halothane. Heart rate and mean arterial pressure was noted prior to induction and 1 min, 5 min, 10 min, 30 min and every half hourly till the end of procedure. Post-operative sedation and the analgesic requirements were also assessed. Results: Perioperatively the mean heart rate was comparable between the two groups. The mean arterial pressure also was comparable between the two groups at all times except at 1 hr where the mean arterial pressure was higher in the oral group compared to the IV group. There was no difference between the two groups in VAS and sedation scores recorded at 30 min intervals till 2 h postoperatively. Time of requirement of first dose of analgesic was also similar between the groups. Conclusion: the administration of both oral clonidine and iv clonidine results in improved perioperative haemodynamic stability which are comparable in its effects.

Asish J.,Sree Gokulam Medical College | Amar M.,Chalmida Anand Rao Institute of Medical science | Hajare V.,Navodaya Medical College | Sreekantha S.,Navodaya Medical College | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Chronic suppurative otitis media(CSOM) has been a source of a tremendous health predicament since time immemorial and even today it is immensely intricate. It is an important cause of hearing impairment which in turn may cause serious long term effect on language, auditory and cognitive development and on educational development.Knowledge of the prevailing flora and their susceptibility to antimicrobials will guide the clinician as to prescribing an empirical regimen so that a better and more specific management can be provided to the patients. Hence this study is done in present secenario to isolate the organims associated with CSOM and its susceptibility pattern. To identify the bacterial and fungal profile of Chronic Suppurative Otitis Media patients. 120 patients attending ENT OPD in Navodaya Medical College Hospital and Research Centre were analysed from Nov 2009 to Oct 2010. Using predefined inclusion and exclusion criteria, samples were obtained using sterile cotton microswabs. These were cultured for microbial flora and were identified. Drug susceptibility was done using Kirby Bauer disc diffusion method. The most common organism isolated was Pseudomonas aeruginosa 33% followed by Staphylococcus aureus 25.8% among the 91 bacterial isolates. This was followed by Proteus mirabilis 20.6%, Enterobacter aerogenes and Streptococcus spp at 4.1%. The organisms were most prevalant in winter and early spring between Nov- Feb. Also maximum number of cases were seen in age group of 21-30 years. The organisms were sensitive to gatifloxacin, cefoperazone sulbactum and ceftriaxone.Fungal isolates accounted for 6.2% of the organism with Aspergillus flavus 3.1%, Aspergillus niger 2.1% and Candida albicans 1%. The study suggests that Pseudomonas aeruginosa and Staphylococcus aureus are the most common etiological agents of CSOM. Most of the strainwere sensitive to fluoroquinolones and cephalosporins.

Alvi A.H.,FMH | Baig M.M.I.,FMMC | Sabir O.,FMH
Medical Forum Monthly | Year: 2015

Objective: We conducted this study to elaborate the etiology and epidemiology of liver diseases presenting during pregnancy. Study Design: It was a prospective, observational study. Place and Duration of Study: This study was conducted in the Department of Gastroenterology, Fatima Memorial Hospital in collaboration with the Department of Obstetrics and Gynaecology from June 2011 -May 2013. Materials and Methods: 73 patients were evaluated. Data was evaluated for quantitative and qualitative variables. Outcome of mother, pregnancy and neonates was also recorded where available. Results: During the study period 73pregnant patients were evaluated for the presence of liver disease giving an incidence of 3.6%. The mean age of the patients was 26.3 ± 3.8 (median: 26, range: 16 - 45) years. The patients presented at a mean gestational age of 5.8 + 2.4 (median: 6, range: 1- 9) months. The mean STB and ALT levels were 11.5 ± 8.5 (median: 9.3, range: 1.4 - 48) mg/dL and 943.5 ± 887.4 (median: 765, range: 13 - 4810) IU/L respectively. The mean duration of jaundice and mean hospital stay were 6.82 + 5.32 (median: 5, range: 2 - 30) days and 5.6 ± 2.7 (median: 5, range: 1-18) days. Fulminant hepatic failure was seen in 6.8% of the patients. Acute Hepatitis E was the most frequent diagnosis in our population. Maternal deaths were seen in 8.2%, foetal deaths were seen in 12.3% and neonatal deaths in 6.5%. Conclusions: Liver diseases during pregnancy can have multiple causes and may predict poor outcomes for the patients and neonates.

Sujatha R.,Shri Sathya Sai Medical College | Rangaswamy R.,Kempegowda Institute of Medical science | Avinash S.S.,FMMC
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Anemia is widely prevalent in India which consists of 80% of villages in India, where Majority of the people is ignorant of the hemopoietic principles of diet belong to low socioeconomic status. Pregnancy Imposes an extra demand on the the nutrients, hence anemia is rather a constant association. Factors such as food which is chiefly derived from local ingredients and secondly prevalence of parasitic infections varies and therefore the pattern of incidence, severity and type of anemia also alters. Anemia in pregnancy is a major public health problem in the developing countries. It is one of the commonest causes of the high maternal mortality rate. It is also responsible for the high incidence of premature and low birth of premature and low birth weight babies, thus increasing the perinatal mortality and morbidity. This study deals with various types of anaemia in pregnant women having Haemoglobin level less than 11gm% and study sensitivity and positive predictive value of Red cell distribution width in diagnosis of Iron deficiency anaemia.

Avinash S.S.,FMMC | Remya,NITTE University | Vinodchandran,Manipal University India
International Journal of Pharma and Bio Sciences | Year: 2014

Dermatoglyphics is influenced by heredity and abnormality in it are associated with chromosomal anamolies. Primary hypertension is polygenic and the scientific dermatoglyphic pattern analysis are rare, which could be used as a diagnostic and screening aid. The present was done to study the frequency distribution of scientific ridge pattern in primary hypertensives. The study was carried out in 200 primary hypertensives with 200 normal controls. The hand imprinting was done using a slight modification of conventional ink flab method. Data were analysed using t test. The primary hypertensive male and female had significantly high frequency of whorls and TFRC and decreased ulnar loops and "atd" angle in both hands. Dermatoglyphics can be considered as a simple, inexpensive aid for screening and diagnosing primary hypertension.

Hariprasad S.,RIMS | Avinash S.S.,FMMC | Vinodchandran,Manipal University India
International Journal of Pharma and Bio Sciences | Year: 2013

OBJECTIVES: Clinical and radiological study of pulmonary tuberculosis in diabetic patients. METHODS: 100 cases of diabetes mellitus with pulmonary tuberculosis were studied. Their clinical profile and chest radiograph results were analyzed. RESULTS: The predominant clinical symptoms noted were anorexia (80%), cough (73%), fever (56%). 62.5% of male patients were smokers.Clubbing was noted in 10% of our patients. Average duration of diabetes was 6.6 years. 51% of patients were anemic and 52% of patients had an erythrocyte sedimentation rate above 50mm/hr. The average FBS value was 234.4 mg/dl. 81% of patients were sputum positive for acid fast bacilli under the age of 40 years. Cavitary lesions were noted in about 53% of patients. 38% of patients had infiltration. Fibrosis was noted in 37% of patients above 40 years. Lower lung field involvement was noted in 32% of patients and was more common in patients greater than 40 years. INTERPRETATION AND CONCLUSION: Multiple cavities and multiple lobe involvement are more common in tuberculous diabetics and lower lung field is involved more commonly in older age group patients.Severe hyperglycemia appears to be a contributory factor to the development of pulmonary tuberculosis in diabetics.Diabetes appears to have no effect on the presenting features of pulmonary tuberculosis to a large extent.

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