FMC BioPolymer

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FMC BioPolymer

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Rosiaux Y.,University of Lille Nord de France | Rosiaux Y.,French Institute of Health and Medical Research | Muschert S.,University of Lille Nord de France | Muschert S.,French Institute of Health and Medical Research | And 8 more authors.
Journal of Controlled Release | Year: 2013

The sensitivity of controlled release dosage forms to the presence of ethanol in the gastro intestinal tract is critical, if the incorporated drug is potent and exhibits severe side effects. This is for instance the case for most opioid drugs. The co-ingestion of alcoholic beverages can lead to dose dumping and potentially fatal consequences. For these reasons the marketing of hydromorphone HCl extended release capsules (Palladone) was suspended. The aim of this study was to develop a novel type of controlled release film coatings, which are ethanol-resistant: Even the presence of high ethanol concentrations in the surrounding bulk fluid (e.g., up to 40%) should not affect the resulting drug release kinetics. Interestingly, blends of ethylcellulose and medium or high viscosity guar gums provide such ethanol resistance. Theophylline release from pellets coated with the aqueous ethylcellulose dispersion Aquacoat® ECD 30 containing 10 or 15% medium and high viscosity guar gum was virtually unaffected by the addition of 40% ethanol to the release medium. Furthermore, drug release was shown to be long term stable from this type of dosage forms under ambient and stress conditions (without packaging material), upon appropriate curing. © 2013 Elsevier B.V.

Zhao G.H.,University of Leeds | Kapur N.,University of Leeds | Carlin B.,FMC Biopolymer | Selinger E.,FMC Biopolymer | Guthrie J.T.,University of Leeds
International Journal of Pharmaceutics | Year: 2011

Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Also considered is the binding that occurs between the MCC and the Na-CMC. Avicel RC 591, a processed mixture of MCC and Na-CMC, is one of the more commonly used commercial suspending agents for aqueous compositions. Avicel RC 591 is used as an effective, blended stabilising agent. In this study, the contributions made by each of the components of Avicel RC 591 have been rationalised by monitoring the behaviour of the individual components in Avicel RC 591 suspensions or solutions. The hydrogels that are formed by Avicel RC 591 and by their laboratory formulated equivalent, which is spray dried (MCC + Na-CMC), have been characterised by confocal microscopy scanning electron microscopy and by dynamic light scattering. A 3D network structure that is formed by the MCC, in Avicel RC 591 is visualised. This network is supported by hydrogen bonding and by ionic interactions among and between the MCC, the Na-CMC and water. The strength of the network determines the physical properties of the hydrogel system, as seen in the rheological behaviour. © 2011 Elsevier B.V. All rights reserved.

Transparency Market Research has released a new market report titled "Xanthan Gum Market for Food & Beverage (Bakery & Confectionery, Dairy & Ice cream, Meat & Fish, Beverages and Sauces & Dressings), Oil & Gas, Pharmaceutical, Personal Care and Other End-users - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2016-2024." According to the report, the global xanthan gum market was valued at US$ 651.5 Mn in 2015 and is projected to reach US$ 1,251.7 Mn by 2024 at a CAGR of 7.7% from 2016 to 2024. The food & beverage industry has been expanding for the last few years owing to an upsurge in customer expenditure and change in consumption patterns. Xanthan gum is widely used as a thickening and emulsion stabilizing agent in various food applications such as sauces, dressings, bakery and dairy products. Product development in this field due to growing awareness for food safety and consumer preference for natural products has increased the consumption of xanthan gum in food & beverage segment. Therefore, growth in the food & beverage industry is likely to provide the essential momentum to the xanthan gum market during the next few years. However, quality concerns regarding the China based xanthan gum, since China is one of the major producer of xanthan gum, is expected to hamper the market during the forecast period. Growing preference for xanthan gum from pharmaceutical and personal care as a bio based stabilizer is anticipated to bring immense opportunities in the market. Get Industry Research Report Sample for more Professional and Technical Industry Insights: In terms of end-user, food & beverage was the largest segment of the global xanthan gum market, accounting for more than 50% share in 2015. The segment is anticipated to continue its dominance during the forecast period due to product development of gluten-free products and sluggish growth in the global oil & gas industry. Xanthan gum is used in the hydraulic fracking process of oil & gas drilling. Substitute products like guar gum encountered price inflation in recent years and therefore is projected to provide an edge to the overall xanthan gum market. Asia Pacific dominates the xanthan gum market, followed by North America. These regions are expected to provide lucrative opportunities for xanthan gum market during the forecast period. Significant expansion in the food & beverage industry, owing to the change in consumption patterns and rise in the customer expenditure, is anticipated to be a key factor driving the xanthan gum market in these regions. Europe, Middle East & Africa and Latin America are estimated to witness reasonable growth in xanthan gum market during the forecast period. The global xanthan gum market is consolidated. Key players include Fufeng Group Company Limited, CP Kelco, Archer Daniels Midland Company, Cargill, Inc., Jungbunzlauer Suisse AG, The Aurora Chemical, MeiHua Holdings Group Co., Ltd, Hebei Xinhe Biochemical Co., Ltd., DuPont-Danisco, Deosen, Solvay S.A., The Zoranoc Oilfield Chemical and FMC BioPolymer. The global xanthan gum market has been segmented as follows: Transparency Market Research (TMR) is a global market intelligence company providing business information reports and services. The company's exclusive blend of quantitative forecasting and trend analysis provides forward-looking insight for thousands of decision makers. TMR's experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information. TMR's data repository is continuously updated and revised by a team of research experts so that it always reflects the latest trends and information. With extensive research and analysis capabilities, Transparency Market Research employs rigorous primary and secondary research techniques to develop distinctive data sets and research material for business reports.

News Article | February 15, 2017

— A basic understanding of binders market is the starting point of this 2017 industry study that provides data for a 10 year period of 2012-2022 (5 historic years, 5 year forecasts) along with competitive landscape scenario covering company profiles and details on their products / offerings. The overview part of this binders market report to 2022 covers production market share by type, providing price list for each type. This is later supported with revenue, price and growth rate of each type for a better understanding of product segments. The consumption market share is studied by application and for each application a major buyers’ (clients) list is provided. This is followed by binders market study by geographies (North America, China, Europe, Japan, India and Southeast Asia), with each region covered for its status and 10 year prospects. Market size of binders is provided in value terms covering production & revenue, production & growth rate as well as revenue & growth rate numbers. Get answers to your questions on this 2017 binders market report, before making a purchase decision, via . 2 binder market product types are discussed in this research for their production, revenue, price, market share and growth rate. Split by application, this report focuses on consumption, market share and growth rate of binders in 2 leading application segments. The competitive landscape scenario for binders market is studied by leading manufacturers and companies active in the industry. This section of the report covers company basic information, manufacturing base, competitors, binders product types, applications and specifications, capacity, production, revenue, price and gross margin (2015 and 2016) as well as overall business overview. Competitive binders market situations and trends broken down into top level pointers like expansions, acquisitions, market concentration rates, top 3 and 5 manufacturers and other developments are offered. Companies discussed in this binders market research along with their product / service offerings include Covestro, TaiWan PU, Technix Rubber And Plastics, OTS, BASF and others. Delivered in a PDF file of 106 pages, the Global Binders Market Research Report 2017 is supported with 127 data tables and figures is now available at . The Global Binders Market Research Report 2017 ends by providing technology analysis, consumer needs and preference details, research findings as well as report conclusion followed by a comprehensive list of data tables and figures. On a related note, the Global Binders Excipients Market Research Report 2017 is of 126 pages, supported with 144 data tables and figures while talking about companies like Ashland, BASF, Colorcon, Croda International, EMD Millipore, Dow Chemical, FMC BioPolymer, Fuji Chemical Industry and Ingredion. Cellulosic, Polyols, Lactose and Other binders excipient products are studied at length as a part of segmentation by type. Split by applications, this report focuses on consumption, market share and growth rate of binders excipients in Tablets, Solvents and Capsules. Read more at . Yet another study titled Global Feed Binder Market Research Report 2016 provides insights into applications and types of feed binders with an outlook to 2021. Companies like Archer Daniels Midland Company, Avebe U.A., Borregaard, Beneo Gmbh, Cp Kelco, Danisco A/S, Fmccorporation, Ingredion Incorporated, The Roquette Group and Uniscope are profiled in this armoured glass market report of 106 pages available at . Explore more reports on chemicals and materials markets at . About Us: aims to provide businesses and organizations market intelligence products and services that help in making smart, instant and crucial decisions. Our database offers access to insights from industry leaders, experts and influencers on global and regional sectors, market trends, user behaviour, for companies as well as products. With data and information from reputable and trusted private and public sources, our clients are never short of statistics and analysis that are up to date. Connect With Us: Market Research Blog: News on current market trends and more: Follow Us on Twitter: Follow us on G+ For more information, please visit

Moroni A.,Glaxo SmithKline CHRandD | Drefko W.,International Specialty Products | Thone G.,FMC BioPolymer
Drug Development and Industrial Pharmacy | Year: 2011

Background: Matrix type, monolithic, dosage forms suitable for controlled release that exhibit pH-dependent behavior are considerably less common than similarly behaving multiparticulated, enterically coated dosage forms, although simpler and less expensive to make. Aim: Evaluate the properties of alginates and alginate-containing systems to produce pH-sensitive, monolithic, controlled release dosage forms that perform acceptably and determine their limits of application in regard with stability, pH and Ca ++ sensitivity, and appropriated rate of release. Method: Mixtures of the ionic gum sodium alginate (Na Alg.) with other gel-forming gums such as propylene glycol alginate (PGA), xanthan, or hydroxypropyl methylcellulose have been evaluated for applicability in the manufacture of controlled release dosage forms with three drugs of different solubility and ionic character. Mixture have been compressed into tablets and tested under a variety of pHs to simulate transit through the GI tract, in the presence of Ca ++, and for stability. Results: These mixtures have been able to sustain drug release for up to 12 hours with acceptable performance going from acidic to alkaline pHs to simulate travel through the GI tract and in the presence of Ca ++. Release rate has been adjusted by selecting a suitable Na Alg./other gum combination at an appropriated ratio. Conclusions: Mixtures of Na Alg. with a number of other gums have been demonstrated suitable to manufacture pH sensitive, matrix-type solid dosage forms with release-controlling properties for up to 12 hours. © 2011 Informa UK, Ltd.

Rosiaux Y.,University of Lille Nord de France | Rosiaux Y.,French Institute of Health and Medical Research | Velghe C.,University of Lille Nord de France | Velghe C.,French Institute of Health and Medical Research | And 8 more authors.
Pharmaceutical Research | Year: 2014

Purpose: To elucidate the mass transport mechanisms controlling drug release from recently proposed, ethanol-resistant, polymeric film coatings. Methods: Theophylline matrix pellets were coated with ethylcellulose: guar gum blends. Drug release from single pellets and ensembles of pellets was measured in various release media. Changes in the systems' morphology, composition and mechanical properties were monitored using SEM, gravimetrical analysis and a texture analyzer. Based on the obtained experimental results a mechanistically realistic mathematical model was identified and used to quantitatively predict drug release from coated pellets in ethanol-free and ethanol-containing bulk fluids. Results: Drug diffusion though the intact polymeric film coatings is likely to be the dominant mass transport mechanism in the investigated systems, irrespective of the ethanol content in the surrounding environment. An appropriate solution of Fick's law could be used to quantitatively predict theophylline release from pellets coated with different ethylcellulose:guar gum blends at different coating levels. Importantly, independent experiments confirmed the theoretical predictions. Conclusions: In silico simulations can help facilitating the optimization of the novel ethanol-resistant polymeric film coatings, avoiding time-consuming and cost-intensive series of trial-and-error experiments. The presence/absence of ethanol does not affect the underlying drug release mechanisms. © 2013 Springer Science+Business Media New York.

Mihranyan A.,Uppsala University | Esmaeili M.,Uppsala University | Razaq A.,Uppsala University | Razaq A.,COMSATS Institute of Information Technology | And 2 more authors.
Journal of Materials Science | Year: 2012

Paper-based conductive electrode materials of polypyrrole (PPy) and nanocellulose (NC) have received much attention lately for applications in non-metal-based energy storage devices, ion exchange, etc. The aim of this study was to study how the primary characteristics of NC raw materials impact and electrochemical properties of conductive NC-PPy composite sheets. Three NC raw materials were used: Cladophora cellulose (NCUU) produced at Uppsala University, Cladophora cellulose (NCFMC) produced at FMC Biopolymer, and microfibrillated cellulose (NC INN) produced at Innventia AB. Composite paper sheets of PPy coated on the substrate NC material were produced. The NC raw materials and the composites were characterized with a battery of techniques to derive their degree of crystallinity, degree of polymerization, specific surface area, pore size distribution, porosity, electron conductivity, charge capacity and tensile properties. It was found that the pore size distribution and overall porosity increase upon coating of NC fibres for all the samples. The charge capacity of the composites was found to decrease with the porosity of the samples. It was further found that the mechanical strength of the pristine NC sheets was largely dependent on the overall porosity, with NC INN having the highest mechanical strength and lowest porosity in the series. The mechanical properties of the composite NC-PPy sheets were significantly diminished as compared with pristine NC sheets because of the impaired H-bonding between fibres and PPy-coated nanofibres. It was concluded that to improve the mechanical properties of PPy-NC sheets, a fraction of additive bare NC fibres is beneficial. Future study may include the effect of both soluble and insoluble additives to improve the mechanical strength of PPy-NC sheets. © Springer Science+Business Media, LLC 2012.

Rosiaux Y.,University of Lille Nord de France | Rosiaux Y.,French Institute of Health and Medical Research | Velghe C.,University of Lille Nord de France | Velghe C.,French Institute of Health and Medical Research | And 8 more authors.
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2013

Recently, ethylcellulose/guar gum blends have been reported to provide ethanol-resistant drug release kinetics from coated dosage forms. This is because the ethanol insoluble guar gum effectively avoids undesired ethylcellulose dissolution in ethanol-rich bulk fluids. However, so far the importance of crucial formulation parameters, including the minimum amount of guar gum to be incorporated and the minimum required guar gum viscosity, remains unclear. The aim of this study was to identify the most important film coating properties, determining whether or not the resulting drug release kinetics is ethanol-resistant. Theophylline matrix cores were coated in a fluid bed with blends of the aqueous ethylcellulose dispersion "Aquacoat® ECD 30" and guar gum. The polymer blend ratio, guar gum viscosity, and degree of dilution of the final coating dispersion were varied. Importantly, it was found that more than 5% guar gum (referred to the total polymer content) must be incorporated in the film coating and that the apparent viscosity of a 1% aqueous guar gum solution must be greater than 150 cP to provide ethanol-resistance. In contrast, the investigated degree of coating dispersion dilution was not found to be decisive for the ethanol sensitivity. Furthermore, all investigated formulations were long term stable, even upon open storage under stress conditions for 6 months. © 2013 Elsevier B.V. All rights reserved.

Muschert S.,University of Lille Nord de France | Siepmann F.,University of Lille Nord de France | Leclercq B.,FMC BioPolymer | Carlin B.,FMC BioPolymer | Siepmann J.,University of Lille Nord de France
Drug Development and Industrial Pharmacy | Year: 2010

Background: Food effects might substantially alter drug release from oral controlled release dosage forms in vivo. Methods: The robustness of a novel type of controlled release film coating was investigated using various types of release media and two types of release apparatii. Results: Importantly, none of the investigated conditions had a noteworthy impact on the release of freely water-soluble diltiazem HCl or slightly water-soluble theophylline from pellets coated with ethylcellulose containing small amounts of PVAPEG graft copolymer. In particular, the presence of significant amounts of fats, carbohydrates, surfactants, bile salts, and calcium ions in the release medium did not alter drug release. Furthermore, changes in the pH and differences in the mechanical stress the dosage forms were exposed to did not affect drug release from the pellets. Conclusion: The investigated film coatings allowing for oral controlled drug delivery are highly robust in vitro and likely to be poorly sensitive to classical food effects in vivo. © Informa UK, Ltd.

Muschert S.,University of Lille Nord de France | Muschert S.,French Institute of Health and Medical Research | Siepmann F.,University of Lille Nord de France | Siepmann F.,French Institute of Health and Medical Research | And 3 more authors.
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2011

When using aqueous polymer dispersions for the preparation of controlled-release film coatings, instability during long-term storage can be a crucial concern. Generally, a thermal after treatment is required to assure sufficient polymer particle coalescence. This curing step is often performed under static conditions in an oven, which is a time-consuming and rather cumbersome process. Dynamic curing in the fluidized bed presents an attractive alternative. However, yet little is known on the required conditions, in particular: temperature, time, and relative humidity, to provide stable film structures. The aim of this study was to better understand the importance of these key factors and to evaluate the potential of dynamic curing compared with that of static curing. Recently proposed ethylcellulose:poly(vinyl alcohol)-poly(ethylene glycol) graft copolymer (PVA-PEG graft copolymer) dispersions were coated on theophylline and metoprolol succinate-loaded starter cores, exhibiting different osmotic activity. Importantly, processing times as short as 2 h were found to be sufficient to provide long-term stable films, even upon open storage under stress conditions. For instance, 2-h dynamic curing at 57 °C and 15% relative humidity are assuring stable film structures in the case of theophylline matrix cores coated with 15% ethylcellulose:PVA-PEG graft copolymer 85:15. Importantly, the approach is also applicable to other types of drugs and starter cores, and the underlying drug release mechanisms remain unaltered. © 2011 Elsevier B.V. All rights reserved.

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