FMABC

São Paulo, Brazil
São Paulo, Brazil
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PubMed | FMABC and University of Sao Paulo
Type: Journal Article | Journal: Revista da Associacao Medica Brasileira (1992) | Year: 2015

The role of adhesion molecules is very important both in the activation of carcinogenesis and in the differentiation of subtypes of breast carcinoma, aiding in diagnosis, prognosis and therapeutic choice in these tumors. Therefore, understanding the functions and interrelationships among these molecules is crucial to the pathologist, who often uses these factors as a resource to differentiate tumors and further classify them according to a molecular point of view. Our goal is to describe the applicability and the difficulties encountered by the pathologist in the diagnosis of breast carcinoma, discussing the most commonly used markers of adhesion in routine analyses.


Objective. Describe physical therapy applied to children with cerebral palsy (CP) spastic quadriplegia attended by scholars of Physiotherapy of Faculdade de Medicina do ABC - FMABC. Method. The study included three female patients. The items that made up the evaluation protocol were: identification, use of medication to decrease tone, use of bracing, physical therapist interaction, language type, age of onset and duration of treatment, patterns and postural changes, joint deformities, weight bearing on standing position, the persistence of tonic neck reflexes, ability to scroll, neck control and shoulder girdle. The physiotherapy sessions were followed by registration of the care protocol. Results. The participants had incomplete control cervical and shoulder girdle absent; only one rolled. The objectives of physical therapy elected with more frequently were: inhibit pathological pattern, decrease muscle tone, increased muscle extensibility, increasing neck control, increase mobility and control of shoulder girdle, to stimulate the roll and provide the benefits of standing. The pipes used to accommodate the proposed objectives formed a physiotherapeutic protocol of individualized care. Conclusion. The treatment applied included: pattern of inhibition, maneuvers to decrease spasticity and facilitation of cervical control, the shoulder girdle and roll.


dos Santos M.T.A.,Federal University of ABC | de Souza F.I.S.,Federal University of São Paulo | Fonseca F.L.A.,University of Sao Paulo | Lazaretti-Castro M.,Disciplina de Endocrinologia e Ambulatorio de Endocrinologia | Sarni R.O.S.,FMABC
Arquivos Brasileiros de Endocrinologia e Metabologia | Year: 2012

Objective: To evaluate bone turnover markers and bone mineral density (BMD) in women after Roux-en-Y (RYGB) gastric bypass. Subjects and methods: In a cross-sectional study, 48 women post-RYGB after three years, and 41 healthy women were evaluated. Evaluations: body mass index (BMI); physical activity; food intake; serum levels of calcium, phosphorus, magnesium, alkaline phosphatase, C-terminal telopeptide (CTX), intact parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), osteocalcin, urinary calcium and BMD. Results: Significantly higher levels were observed for osteocalcin (p < 0.001), CTX (p < 0.001), and PTH (p < 0.001) in the RYGB group when compared with the control group; 250HD deficiency/insufficiency was more frequent in the RYGB group (p = 0.010), even after adjusted for nutritional status, and it was associated with secondary hyperparathyroidism (p = 0.025); there was no difference in BMD between the groups. Energy (p = 0.036) and protein intake (p = 0.004) were lower in the RYGB group. Conclusion: Patients submitted to RYGB showed a significantly higher frequency of vitamin D deficiency, secondary hyperparathyroidism, and increase in bone remodeling markers, with no difference in BMD status.


Iampolsky M.N.,FMABC | De Souza F.I.S.,Servico de Nutrologia | Sarni R.O.S.,Servico de Nutrologia | Sarni R.O.S.,University of Sao Paulo
Revista Paulista de Pediatria | Year: 2010

Objective: To evaluate blood pressure levels in children, relating them to body mass index and abdominal circumference. Methods: This cross-sectional prospective study enrolled 1.408 school children, aged between five and ten years and 11 months, in the municipality of Santo Andre, São Paulo, Brazil. The following variables were evaluated: birth weight, weight and height, expressed as body mass index Z score (ZBMI) and height to age Z score (ZH), and waist circumference (WC). Blood pressure was measured once by the same physician. Malnutrition was considered when ZBMI <-2, obesity when ZBMI >+2, short stature when ZH <-2, increased abdominal circumference when >P90 for age and gender, and increased blood pressure when >P90 for age, gender and height. Statistical analysis included chi-square test and Odds Ratio, being significant p<0.05. Results: Mean age was seven years old, and 51% were females. High systolic blood pressure levels were observed in 19% and elevated diastolic blood pressure in 12%. Short stature, malnutrition, obesity and increased abdominal circumference were diagnosed in 2.6%, 3.1%, 7.3% and 13.4%, respectively, of the studied population. The presence of obesity was strongly associated with high systolic (OR 2.1, 95%IC 1.3-3.3; p<0.001) and diastolic blood pressure (OR 2.6, 95%IC 1.6-4.3; p<0.001). Increased abdominal circumference was also an important risk factor for high systolic blood pressure (OR 1.6; 95%IC 1.0-2.5; p=0.027). Conclusions: High blood pressure in children is associated with obesity and increased abdominal circumference.


PubMed | Santa Casa Of Sao Paulo Hospital, FMABC, Federal University of ABC, University of Sao Paulo and Institute at Hospital do Coracao
Type: Journal Article | Journal: Revista da Associacao Medica Brasileira (1992) | Year: 2015

acute coronary syndromes (ACS) represent a widely prevalent health issue with high mortality in Brazil and worldwide. The severity of ACS is not known in patients in the city of So Bernardo do Campo a municipality contiguous and adjacent to the city of So Paulo.to study the profile of coronary disease in patients hospitalized with ACS who underwent coronary angiography in the emergency room between 2012 and 2013.this is an observational study that included consecutive patients with ACS admitted to the emergency room of a hospital. Data collection was performed using medical records with the following variables: sex, age, risk factors for cardiovascular disease, coronary angiography.the sample in this period included 131 patients, of which 64.8% were men. The most prevalent diagnosis was ST-elevation myocardial infarction (STEMI) (57.2%) followed by non-ST-elevation myocardial infarction (NSTEMI) (22.1%) and unstable angina (UA) (20.6%). There were no significant differences in the epidemiology and risk factors between the diagnoses, except that heart failure was more prevalent in patients with UA.there were no differences between groups regarding the coronaries involved; however, STEMI patients showed similar numbers of multi- and singlevessel lesions, NSTEMI patients showed more multivessel lesions, and UA patients showed more multivessel lesions or lesion-free arteries. Although multivessel lesions were prevalent in all groups, STEMI patients showed a significantly higher number of single-vessel lesions compared with the other acute coronary syndromes.the study demonstrated a predominance of STEMI in the studied population, which differs from the usual results in ACS.


Oliveira H.F.,Federal University of Sergipe | Martins L.C.,FMABC | Reato L.D.F.N.,Institute Hebiatria | Akerman M.,FMABC
Revista Paulista de Pediatria | Year: 2010

Objective: To evaluate risk factors for tobacco use in high school students of two schools of the city of Santo Andre (São Paulo, Brazil) in 2005, as well as to describe the profile of the adolescent who uses tobacco. Methods: Cross sectional study that applied a standardized anonimous self-answered questionnaire in adolescents of both genders registered in the first year of a public and a private high school of the city of Santo André (Brazil). The following variables were collected: age, gender, race, practice of sports, religion and habits of the family/adolescent. "Tobacco trier" was defined as those who tried cigarette and did not continue with smoking habits, excluding those who inhaled illicit drugs. Statistical analysis applied chi-square test and logistic regression. Results: A total of 226 (90%) questionnaires were answered: 137 (61%) in the private and 89 (39%) in the public school. Among the adolescents, 54 (24%) used tobacco (35 - private school and 19% - public school). Significant variables associated with tobacco use in the private school were: maternal smoking (OR 12.44; 95%CI 4.10-37.79) and friends who are smokers (OR 9.58; 95%CI 3.10-29.98). In the public school, the risk factors for smoking were: alcoholic beverage use (OR 8.78; 95%CI 1.92-40.06), smoking among friends (OR 7.90; CI95%: 1.99-31.29) and contact with cigarette smoke (OR 6.40; 95%CI 1.56-26.22). Conclusions: A significant influence of social and family environment was observed regarding the use of tobacco by adolescents.


Objective. To review the literature about perinatal asphyxia (PA), collecting information about injury mechanisms, consequences, possible neurological sequelae, and early identification. Method. Electronic search of the databases SciELO, BIREME, Medline, selecting 26 articles and three books. Results. The lack of consensus to define perinatal asphyxia justifies the difficulty to establish prevalence data. The current definitions are based on a combination of indicators and not only in low Apgar score. Its pathophysiology is based on hypoxic-ischemic injury, resulting in multiple organ failure and brain damage. The hypoxic-ischemic encephalopathy is the most serious consequence of perinatal asphyxia, which causes neurologic sequelae. The neonatal neurologic assessments assist in the detection of abnormalities, allowing early treatment and optimizing prognosis. However there are few studies that have used such evaluation methods in this population. Conclusion. The literature which addresses the theoretical concepts of the PA, such as diagnosis, risk factors and pathophysiology is much more extensive than the number of studies reporting its consequences.


Rstom S.A.,Federal University of ABC | Abdalla B.M.Z.,FMABC | Rezze G.G.,Hospital AC Camargo | Paschoal F.M.,FMABC
Surgical and Cosmetic Dermatology | Year: 2014

Introduction:Chronic exposure to ultraviolet radiation is the primary cause of skin carcinomas. Actinic keratosis is considered a precursor lesion. Topical application of photolyase showed effectiveness with the removal of 40-45% of the dimers formed by ultraviolet radiation, contrasting with conventional photoprotection for its ability to repair already damaged cellular DNA. Confocal microscopy is used for the in vivo visualization of skin alterations. Objective:To evaluate the effects of the cream containing photolyase and SPF 100 sunscreen on facialactinic damage and keratoses, using dermoscopy and confocal microscopy as evaluation parameters. Methods: Observational longitudinal clinical trial in 17 actinic keratosis lesions. Dermatoscopy and confocal microscopy were carried out before applying the cream and 120 days after, with comparison of the images. Results: Of the 14 Grade I actinic keratoses, nine showed clinical and dermoscopic improvement, three remained unchanged and one progressed to Grade II actinic keratosis. Confocal microscopy showed a reduction of scales and improvement in the epidermal architecture in the five Grade I actinic keratoses. The three Grade II actinic keratoses analyzed did not show improvement. Conclusions: The application of photolyase in cream with sunscreen promotes photoprotection and DNA repair. Confocal microscopy is a useful tool for monitoring the treatment of actinic keratoses.


Da Cunha M.G.,Federal University of ABC | Da Cunha A.L.G.,Federal University of São Paulo | Machado C.A.,FMABC
Surgical and Cosmetic Dermatology | Year: 2014

In the literature there is significant confusion between the terms hypodermis and subcutaneous adipose tissue, which are often used interchangeably. They are however two distinct and independent structures, with independent metabolic responses. The distinction between these two layers and the knowledge of their behavior is of crucial importance for choosing the appropriate treatment. The objective of the present study was to review the existing literature on the topic, in order to demonstrate the anatomical and histological differences between the two tissues.


Background: The classical view of adipose tissue as a passive reservoir for energy storage is no longer valid. In the past decade, adipose tissue has been shown to have endocrine functions and the most abundant peptide secreted by adipocytes is adiponectin. Pericardial adipose tissue (PAT) is distributed around coronary arteries and endovascular injury, caused by the presence of intracoronary bare-metal stent (BMS), could promote inflammatory changes in the periadvential fat, contributing to vascular restenosis. Objective: We sought to determine gene expression of inflammatory mediator in pericardial adipose tissue after bare-metal stent implantation and vascular restenosis that had been referred to operative treatment. Methods: Paired samples of PAT were harvested at the time of elective coronary artery bypass surgery (CABG) in 11 patients (n=22), one sample was obtained of the tissue around BMS area and another sample around coronary artery without stent. Local expression of adiponectin was determined by real-time polymerase chain reaction (RTPCR) using Taq DNA polymerase. Results: In two samples, there was no gene expression of adiponectin. We are able to identify adiponectin in 20 samples, however, the pattern of gene expression were heterogeneous.We did not notice specificity when we compared PAT obtained near BMS area or far from BMS area. Conclusion: There were no correlation between adiponectin gene expression and presence of BMS.

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