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Lu Y.,Fluorous Technologies | Nagashima T.,Fluorous Technologies | Miriyala B.,Fluorous Technologies | Conde J.,Fluorous Technologies | And 2 more authors.
Journal of Combinatorial Chemistry | Year: 2010

A fluorous linker-assisted synthetic protocol has been developed for preparation of sclerotigenin-type benzodiazepine-quinazolinone library containing 144 analogues. Amide coupling of fluorous trimethoxybenzyl (TMB)-protected amino esters with anthranilic acids followed by base-promoted cyclizations afforded 4-benzodiazepine-2,5-diones. Further derivatization of benzodiazepinediones by reacting with azidobenzoyl chlorides, cyclization, and fluorous linker cleavage afforded the desired compound library. The reaction intermediates were purified by fluorous solid-phase extraction (F-SPE) and final products were further purified by prep-HPLC. © 2010 American Chemical Society.


Lu Y.,Fluorous Technologies | Geib S.J.,University of Pittsburgh | Damodaran K.,University of Pittsburgh | Sui B.,University of Pittsburgh | And 3 more authors.
Chemical Communications | Year: 2010

Fluorous diastereomeric mixture synthesis (FDMS) is introduced and demonstrated in the synthesis of six diastereomers of hydantoin-fused hexahydrochromeno[4,3-b]pyrroles. © 2010 The Royal Society of Chemistry.


Yu M.S.,Fluorous Technologies
Topics in Current Chemistry | Year: 2012

Fluorous modified reagents and scavengers have been widely used in the synthesis of small molecules and small molecule libraries. This chapter highlights some of those applications based on type of transformation and reagent or scavenger. © 2011 Springer-Verlag Berlin Heidelberg.


Fluorous Technologies | Entity website

Fluorous Oligonucleotide Synthesis Benefits of Fluorous Oligonucleotide Synthesis Streamline your workflow with one pass loading without ammonia removal Obtain high selectivity and recovery, especially with long oligonucleotides (50-100+ mers) Integrate fluorous techniques easily with 'plug and play' protocols Solid phase oligonucleotide synthesis with terminal fluorous tagging As shown in Figure 1, this strategy uses a terminal fluorous tag with conventional solid-phase oligonucleotide synthesis. In the example shown, each iteration of the traditional solid-phase synthesis is followed by an acetate capping step ...


Fluorous Technologies | Entity website

Fluorous Peptide Synthesis Benefits of fluorous techniques in peptide synthesis Streamline your peptide synthesis workflow Minimize purification method development by using a single general purification technique Increase final HPLC purification efficiency through fluorous pre-purification Easily remove deletion sequences in solid phase peptide synthesis Fluorous techniques can simplify and streamline your peptide synthesis and purification whether you are making peptide libraries in small quantities or single therapeutic peptides in large quantity. The key to the purification is fluorous solid phase extraction (FSPE), a single general purification technique that is applicable over a wide range of peptides ...


PubMed | Fluorous Technologies
Type: Journal Article | Journal: Journal of combinatorial chemistry | Year: 2010

A fluorous linker-assisted synthetic protocol has been developed for preparation of sclerotigenin-type benzodiazepine-quinazolinone library containing 144 analogues. Amide coupling of fluorous trimethoxybenzyl (TMB)-protected amino esters with anthranilic acids followed by base-promoted cyclizations afforded 4-benzodiazepine-2,5-diones. Further derivatization of benzodiazepinediones by reacting with azidobenzoyl chlorides, cyclization, and fluorous linker cleavage afforded the desired compound library. The reaction intermediates were purified by fluorous solid-phase extraction (F-SPE) and final products were further purified by prep-HPLC.


PubMed | Fluorous Technologies
Type: | Journal: Topics in current chemistry | Year: 2011

Fluorous modified reagents and scavengers have been widely used in the synthesis of small molecules and small molecule libraries. This chapter highlights some of those applications based on type of transformation and reagent or scavenger.


PubMed | Fluorous Technologies
Type: Journal Article | Journal: Tetrahedron | Year: 2010

Miscibility tests between sixty pairs of fluorous and organic solvents have been performed, and a number of biphasic systems based on hydrofluoroether solvents have been identified. Mutual solubilities of a series of fluorous and organic solvents have been measured to ascertain the compositions of the biphasic systems. A qualitative solvent tuning strategy based on solvent polarity and fluorophilicity/phobicity is introduced. Solvent tuning is then used to modulate the partition coefficients (P) of triarylphosphines with 0-3 fluorous tags. The results lay a foundation for future applications of these and related biphasic systems in catalysis and extraction.


Fluorous Technologies | Entity website

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