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Tarnaka, India

Venkat Lingaiah B.P.,Fluoroorganics Division | Yakaiah T.,Fluoroorganics Division | Chandra Shekhar A.,Fluoroorganics Division | Ravi Kumar A.,Fluoroorganics Division | And 8 more authors.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2012

A series of novel α-amino acid functionalized 6-fluoro quinolone derivatives have been synthesized from quinoline ester 2 in series of steps with good yields. The compounds have been screened against gram-positive and gram-negative bacteria in-vitro. Some compounds show promising activity against all species of gram-positive and gram-negative bacteria, with reference to standard Norfloxacin as well as Ciprofloxacin. The activity data is validated by molecular docking studies and are in good co-relation with observed trends. Source

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