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Grenoble, France

Dorval P.,CNRS Computer Science and Engineering Laboratory | Mangeret N.,Fluoptics | Guillermet S.,Fluoptics | Atallah I.,Joseph Fourier University | And 6 more authors.
Physica Medica | Year: 2015

In laparotomy surgery guided by near-infrared fluorescence imaging, the access to the field of operation is limited by the illumination and/or the imaging field. The side of cavities or organs such as the liver or the heart cannot be examined with the systems available on the market, which are too large and too heavy. In this article, we describe and evaluate a palm sized probe, whose properties, weight, size and sensitivity are adapted for guiding laparotomy surgery.Different experiments have been performed to determine its main characteristics, both on the illumination and imaging sides. The device has been tested for fluorescent molecular probe imaging in preclinical procedures, to prove its ability to be used in cancer nodule detection during surgery. This system is now CE certified for clinical procedures and Indocyanine Green imaging has been performed during clinical investigations: lymphedema and surgical resection of liver metastases of colorectal cancers. © 2015 Associazione Italiana di Fisica Medica. Source

Rizo P.,Fluoptics | Dinten J.-M.,CEA Grenoble | Texier I.,CEA Grenoble
Bio Tribune Magazine | Year: 2010

Fluorescence probes and imaging methods have been extensively developed in microscopy to visualize biological pathways, cell trafficking and intracellular interactions, which are the main targets of molecular imaging. The translation of these methods from microscopy to preclinical and clinical applications requires to image through large thickness of live biological tissues, and to ensure the non-toxicity of the probes. We hereafter list the main issues that must be addressed to translate fluorescence techniques to clinic, and we present the main envisioned solutions. As first realistic clinical application, we present work in progress on intraoperative fluorescence guided surgery. © 2009 Springer Verlag France. Source

Wenk C.H.F.,French Institute of Health and Medical Research | Wenk C.H.F.,Joseph Fourier University | Ponce F.,VetAgro Sup | Guillermet S.,Fluoptics | And 10 more authors.
Cancer Letters | Year: 2013

We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14. ±. 1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1. year after the beginning of the study. © 2012 Elsevier Ireland Ltd. Source

Fluoptics | Date: 2012-10-23

Fluorescence imaging apparatus for medical use in surgery in the medical and veterinary fields and in the fields of pharmaceutical and biological research, including a source of illumination in white light, a fluorescent marker excitation source and a device for detecting fluorescence.

Fluoptics | Date: 2013-04-23

Fluorescence imaging system for an operating theatre, comprising a device illuminating the operating theatre and emitting a white light, and a fluorescence imaging device. Said fluorescence imaging device comprises a light source emitting radiation for excitation of a fluorescent marker in a range of emission wavelengths of between 600 and 900 nm. The light emitted by the illuminating device is filtered by a low-pass filter, of which the cut-off wavelength is below the emission range of the fluorescent marker, but is nonetheless able to show an increase or fluctuations in the attenuation for wavelengths above the emission range of the fluorescent marker, the product of the attenuation of the filter of the detector and of the attenuation of the low-pass filter of the illuminating device leading to an attenuation by a factor of at least 10

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