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Greener J.,University of Toronto | Greener J.,FlowJEM Inc. | Tumarkin E.,University of Toronto | Debono M.,University of Toronto | And 3 more authors.
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2012

We demonstrate continuous flow acid-base titration reactions as an educational microfluidic platform for undergraduate and graduate analytical chemistry courses. A series of equations were developed for controlling and predicting the results of acid-base neutralisation reactions conducted in a microfluidic format, including the combinations of (i) a strong base and a strong acid, (ii) a strong base and a weak acid, and (iii) a strong base and a multiprotic acid. Microfluidic titrations yielded excellent repeatability. The small experimental footprint is advantageous in crowded teaching laboratories, and it offers limited waste and exposure to potentially hazardous acids and bases. This platform will help promote the utilisation of microfluidics at an earlier stage of students' careers. © 2012 The Royal Society of Chemistry. Source

Greener J.,University of Toronto | Greener J.,FlowJEM Inc. | Tumarkin E.,University of Toronto | Debono M.,University of Toronto | And 6 more authors.
Analyst | Year: 2012

We report the development of a versatile microfluidic (MF) reactor with multiple analytical probes, which can be used for (i) quantitative characterisation of molecular vibrational signatures of reactants or products, (ii) the localised real-time monitoring of temperature and (iii) site-specific measurements of pH of the reaction system. The analytical probes utilised for in situ reaction analysis include an ATR-FTIR probe, a temperature probe, and a pH probe. We demonstrate the applications of the MF reactor with integrated probes for the parallel monitoring of multiple variables in acid/base neutralisation reaction, of changes in buffer pH, temperature, and vibrational absorption bands, and for monitoring the kinetics of the reaction between CO 2 and a buffer system with therapeutic applications. © 2012 The Royal Society of Chemistry. Source

Voicu D.,University of Toronto | Scholl C.,University of Toronto | Li W.,University of Toronto | Jagadeesan D.,University of Toronto | And 5 more authors.
Macromolecules | Year: 2012

We report a high-throughput study of the kinetics of a multicomponent polymerization reaction in a microfluidic reactor integrated with in situ attenuated total reflection Fourier transform infrared spectroscopy. The technique was used to study the kinetics of an exemplary free-radical polymerization reaction of N-isopropylacrylamide, which was initiated by ammonium persulfate in the presence of the accelerator N,N,N′,N′- tetramethylethylenediamine in water. By monitoring the rate of disappearance of the monomer double bonds, we determined the effects of the concentration of the monomer, initiator, and accelerator on the rate of polymerization and the effect of the pH of the reaction system on the reaction kinetics. This work opens the way for the kinetic studies of complex polymer systems in a microfluidic format. © 2012 American Chemical Society. Source

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