Badawy R.A.B.,Epilepsy Research Center |
Badawy R.A.B.,University of Melbourne |
Badawy R.A.B.,Florey Neuroscience Institutes Heidelberg West |
Jackson G.D.,Epilepsy Research Center |
And 8 more authors.
International Journal of Neural Systems | Year: 2013
Transcranial magnetic stimulation was used to study the effect of recurrent seizures on cortical excitability over time in epilepsy. 77 patients with firm diagnoses of idiopathic generalized epilepsy (IGE) or focal epilepsy were repeatedly evaluated over three years. At onset, all groups had increased cortical excitability. At the end of follow-up the refractory group was associated with a broad increase in cortical excitability. Conversely, cortical excitability decreased in all seizure free groups after introduction of an effective medication. © 2013 World Scientific Publishing Company.