Calota D.R.,Clinical Emergency Hospital for Plastic |
Nitescu C.,Clinical Emergency Hospital for Plastic |
Marinescu S.,Bagdasar Arseni Emergency Hospital |
Cristescu C.,Carol Davila University of Medicine and Pharmacy |
And 3 more authors.
Romanian Journal of Morphology and Embryology | Year: 2012
Extensive burns are devastating traumatic events, with significant potential for development of complex psychosocial problems. The aim of the study was to identify and quantify these difficulties among extensive burns patients. This study was conducted at Clinical Emergency Hospital for Plastic, Reconstructive and Burns Surgery and "Bagdasar-Arseni" Emergency Hospital, in Bucharest, on 43 extensive burn patients. For each patient we developed a statistic sheet with demographic data and medical information. For data collection, subjects completed the following instruments: Hamilton Depression Scale (HAMD) and Satisfaction With Appearance Scale (SWAP). The impact variables evaluated in this study were demographic characteristic of patients, burn injury characteristics, abnormal scarring and visible scars, body image dissatisfaction and depression symptoms. Although performed on a small sample, the results of this pilot study could be a valuable starting point for future larger studies, to achieve more generalizable results on extensive burns survivor's quality of life.
Vaccarino V.,Emory University |
Badimon L.,Cardiovascular Research Center |
Corti R.,University of Zürich |
De Wit C.,University of Lübeck |
And 6 more authors.
Nature Reviews Cardiology | Year: 2013
Scientific interest in ischaemic heart disease (IHD) in women has grown considerably over the past 2 decades. A substantial amount of the literature on this subject is centred on sex differences in clinical aspects of IHD. Many reports have documented sex-related differences in presentation, risk profiles, and outcomes among patients with IHD, particularly acute myocardial infarction. Such differences have often been attributed to inequalities between men and women in the referral and treatment of IHD, but data are insufficient to support this assessment. The determinants of sex differences in presentation are unclear, and few clues are available as to why young, premenopausal women paradoxically have a greater incidence of adverse outcomes after acute myocardial infarction than men, despite having less-severe coronary artery disease. Although differential treatment on the basis of patient sex continues to be described, the extent to which such inequalities persist and whether they reflect true disparity is unclear. Additionally, much uncertainty surrounds possible sex-related differences in response to cardiovascular therapies, partly because of a persistent lack of female-specific data from cardiovascular clinical trials. In this Review, we assess the evidence for sex-related differences in the clinical presentation, treatment, and outcome of IHD, and identify gaps in the literature that need to be addressed in future research efforts. © 2013 Macmillan Publishers Limited. All rights reserved.
PubMed | Transilvania University of Brasov, University Vasile Goldis, Floreasca Emergency Hospital, County Emergency Hospital Ramnicu Sarat and 2 more.
Type: | Journal: Internal and emergency medicine | Year: 2016
Drawings made by training children into cardiopulmonary resuscitation (CPR) during the special education week called School otherwise can be used as non-verbal means of expression and communication to assess the impact of such training. We analyzed the questionnaires and drawings completed by 327 schoolchildren in different stages of education. After a brief overview of the basic life support (BLS) steps and after watching a video presenting the dynamic performance of the BLS sequence, subjects were asked to complete a questionnaire and make a drawing to express main CPR messages. Questionnaires were filled completely in 97.6% and drawings were done in 90.2% cases. Half of the subjects had already witnessed a kind of medical emergency and 96.94% knew the correct 112 emergency phone number. The drawings were single images (83.81%) and less cartoon strips (16.18%). Main themes of the slogans were Save a life!, Help!, Call 112!, Do not be indifferent/insensible/apathic! through the use of drawings interpretation, CPR trainers can use art as a way to build a better relation with schoolchildren, to connect to their thoughts and feelings and obtain the highest quality education.
Petris A.,Grigore T. Popa University of Medicine and Pharmacy |
Tatu-Chitoiu G.,Floreasca Emergency Hospital |
Costache I.,Grigore T. Popa University of Medicine and Pharmacy |
Tint D.,Transilvania University of Brasov
Molecular Crystals and Liquid Crystals | Year: 2016
For the old old patients (pts) with congestive heart failure the use of combinations of drugs can easily lead to a sort of “evidence-based” polypragmasie. We analyzed a lot of 125 pts with congestive heart failure older than 85 years (mean 87.43 +/− 2.54 years), 53.6% male, enrolled consecutively between January 2011 – December 2012. We have compared some features of two subgroups: survivors' (S = 112 pts) vs deceased (D = 13 pts). The old old patients group included patients with length of hospitalization of 8.10+/−3.98 days and the rate of rehospitalization 6.4% and the death rate 10.4%. Number of drugs taken was 5.53+/−1.86 in S group vs 5.85+/−1.86 in D group (p = 0.560) and the length-of-stay was 8.18+/−3.79 in S group vs 7.38+/−5.53 in D group (p = 0.494). There were significant differences between group S vs D in: NYHA class, atrial fibrillation, hemoglobin level, blood urea nitrogen, and serum sodium. The number of drugs given to old old patients has not proven to reduce the length of stay, the rate of death and rehospitalization. Hyponatremia, anemia, increased BNP, blood urea nitrogen and serum uric acid are associated with increased mortality of old old patients. © 2016 Taylor & Francis Group, LLC.
Stefanescu O.,Prof Dr Agrippa Ionescu Emergency Hospital |
Enescu D.M.,Grigore Alexandrescu Emergency Hospital for Children |
Lascar I.,Floreasca Emergency Hospital
Romanian Journal of Morphology and Embryology | Year: 2012
Current techniques in tissue engineering may offer a choice regarding the reconstructive strategies of peripheral nerves. Schwann cell cultures are to be considered an appropriate option in the reconstruction of peripheral nerve and spinal cord large defects. Schwann cells availability from peripheral nerve autografts creates a great benefit concerning their usefulness in the nervous autogenic transplantation. Allogeneic Schwann cells transplantation can be effective in the reconstruction without delay of peripheral nerve defects.
Necula L.G.,Stefan S Nicolau Institute Of Virology |
Chivu-Economescu M.,Stefan S Nicolau Institute Of Virology |
Stanciulescu E.L.,Floreasca Emergency Hospital |
Bleotu C.,Stefan S Nicolau Institute Of Virology |
And 6 more authors.
Journal of Gastrointestinal and Liver Diseases | Year: 2012
Background & Aims. A point mutation (gp130Y757F/ Y759F) was identifed as being responsible for aberrant activation of gp130 in mice and associated with gastric adenocarcinoma induction. As a result, we investigated the possible role of key point mutations in Tyr from IL6ST exon 17 that encode for the catalytic domain of gp130, and of its respective activators (IL-6 family member cytokines) in human gastric cancer initiation and development. method. DNA, protein and plasma from 51 patients with gastric adenocarcinoma have been used in exploring gp130 status. We used sequencing analysis of IL6ST exon 17 in order to identify possible mutations that would lead to constitutive active forms of the receptor. The levels of gp130 activators (IL-6, IL-11, LIF) were analyzed by ELISA in plasma and mucosa of patients with gastric adenocarcinoma. Results. Sequencing analysis did not identify mutations in gp130 key positions (Y759, Y767, Y814, Y905 and Y915). An increased IL-6 and IL-11 level in gastric mucosa was observed, correlated with staging, indicating these cytokines as gp130 activators in tumor epithelial cell. Those variations were consistent with increased IL-6 level in plasma. Furthermore, IL-6, but not IL-11 showed a significant correlation with patient's survival time, suggesting that tissue and plasma concentration of IL-6 might be a marker of tumor aggressiveness with prognostic value. Conclusions. According to our results, no mutations were detected in gp130 key positions in human gastric adenocarcinoma samples. However, gp130 activation may occur due to the increased level of IL-6 and IL-11 cytokines detected that can become valuable biomarkers.
Iconaru S.L.,National Institute of Materials Physics Bucharest |
Prodan A.M.,Carol Davila University of Medicine and Pharmacy |
Prodan A.M.,Floreasca Emergency Hospital |
Le Coustumer P.,University of Bordeaux 1 |
And 2 more authors.
Journal of Chemistry | Year: 2013
The glycerol iron oxide nanoparticles (GIO-NPs) were obtained by an adapted coprecipitation method. The X-ray diffraction (XRD) studies demonstrate that GIO-NPs were indexed into the spinel cubic lattice with a lattice parameter of 0.835 nm. The refinement of XRD spectra indicated that no other phases except maghemite were detected. The adsorption of glycerol on iron oxide nanoparticles was investigated by Fourier transform infrared (FTIR) spectroscopy. On the other hand, this work implicated the use of GIO-NPs in antibacterial studies. The results indicate that, in the case of P. aeruginosa 1397 biofilms, at concentrations from 0.01 mg/mL to 0.625 mg/mL, the glycerol iron oxide inhibits the ability of this strain to develop biofilms on the inert substratum. © 2013 Simona Liliana Iconaru et al.
Tirziu C.,Floreasca Emergency Hospital
Romanian journal of internal medicine = Revue roumaine de médecine interne | Year: 2010
In the general context of increasing prevalence of cardiovascular risk factors in European population, we face with a significant rise of the incidence of atherothrombotic diseases. Peripheral arterial disease (PAD) represented for a long time a peripheral interest for cardiologist. The epidemiological studies in the latest years determine a reconsideration of the medical attitude in respect of PAD, motivated by an increase in its prevalence and, on the other hand, by the significant cardiovascular risk this disease carries with. Taking into account that fact and aiming at a better medical approach of these patients, we realized a review regarding therapeutic methods in patients with PAD and intermittent claudication based on the latest medical publications and in accord with the guide in force at the moment.
Tatu-Chitoiu G.,Floreasca Emergency Hospital
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology | Year: 2012
A national programme for PPCI in STEMI patients was started in Romania in August 2010, based on an integrated and well-trained pre-hospital emergency medical system. Ten national centres experienced in PPCI were organised in a 24/7 system in five regional networks, in order to assist STEMI patients from areas offering PPCI within the first two hours after the first medical contact. For centres located further away, a strategy of local thrombolysis followed by transfer to the closest PCI centre was recommended. The total number of PPCI procedures increased from 1,289 in 2010 to 4,209 in 2011. The percentage of PPCI increased from 25.0% in 2010 to 49.32% in 2011. From 40 PPCI/million inhabitants in 2009, we reached 64/million in 2010 and 210/ million in 2011. In the Bucharest area there were 640 PPCI/ million in 2011. The global in-hospital mortality decreased from 13.5% in 2009 to 9.93% in 2011. In 2011 in-hospital mortality was 4.39%, 8.32% and 17.11% for PPCI, thrombolysis and no-reperfusion, respectively. In-hospital mortality was 7.28% in the PCI centres but 14.20% in centres without PCI facilities. The national programme for PPCI had a major impact on STEMI in-hospital mortality in Romania.
The correlation between burn size and serum albumin level in the first 48 hours after burn injury [Corelaţia dintre întinderea arsurii şi nivelul albuminei plasmatice din primele 48 de ore postarsurǎ]
Cucereanu-Badica I.,Floreasca Emergency Hospital |
Luca-Vasiliu I.,Floreasca Emergency Hospital |
Grintescu I.,Floreasca Emergency Hospital |
Lascar I.,Floreasca Emergency Hospital
Jurnalul Roman de Anestezie Terapie Intensiva/Romanian Journal of Anaesthesia and Intensive Care | Year: 2013
Goal: To determine whether burn size in severely burned patients (more than 25% of body surface area covered with second and third degree burns) influences the level of serum albumin during the first 48 hours after burn injury. Material and method: This was a retrospective study of forty-seven patients with severe burns ranging from 25% to 90% of total body surface area consecutively admitted to intensive care unit of the Emergency Hospital of Bucharest from January 2006 to December 2012. We studied the relationship between burned surface area and the lowest serum albumin level during the first 48 hours after injury. Results: There was a negative linear correlation between the burned surface area and serum albumin level during the first 48 hours post injury. We find a mathematic relationship to express this correlation and to calculate the expected level of serum albumin for a specific burned body surface area. Conclusions: There is a negative correlation between burned surface area and serum albumin level; we proposed a linear polynomial fit in order to describe this correlation. Based on this relationship between those two parameters we suggest administration of intravenous albumin in the first 24 hours post injury, during the initial phase of fluid resuscitation when we would expect low levels of plasma albumin.