LONGMONT, CO, United States
LONGMONT, CO, United States

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Grant
Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase II | Award Amount: 750.00K | Year: 2011

On the battlefield, medics must quickly determine injury severity, treat the greatest threats to life, diagnose hemorrhage and establish a triage order. The objective of this research project is to apply our active, long-term learning technology to the task of modeling and prediction of central blood volume parameters from extremely large, and variable physiological datasets. In Phase I, we applied our feature extraction and modeling techniques to data gathered from human lower body negative pressure studies simulating acute blood loss at the U.S. Army Institute of Surgical Research. We discovered several previously hidden hemodynamic relationships that are predictive of acute blood loss volume and an individual"s risk for cardiovascular collapse. This work has led to the development of an entirely new type of intelligent, non-invasive medical device, which we call CipherSensor. In Phase II we will integrate the CipherSensor technology into the FDA approved Nexfin monitor and Flashback"s own portable device based on pulse oximetry (CipherOx). These prototype devices will be used to collect acute blood loss data in clinical and experimental settings. The collected data will be used to build more robust and accurate models of early hemorrhage detection and resuscitation effectiveness, as well as preparation for pre-clinical tests.


Patent
The Regents Of The University Of Colorado and Flashback Technologies, LLC | Date: 2012-07-20

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patients current hemodynamic reserve index, track the patients hemodynamic reserve index over time, and/or predict a patients hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patients dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patients estimated and/or predicted hemodynamic reserve index.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2016-09-09

Novel tools and techniques are provided for assessing, predicting and/or estimating a physiological state of a patient, based on variance of the patients compensatory reserve index (CRI) before, during, and/or after a physical perturbation. In some embodiments, the system might receive a first set of physiological data from one or more sensors at a first time relative to a physical perturbation of the patient, and might calculate a first set of CRI values of the patient. The system might receive a second set of physiological data at a second time relative to the physical perturbation, calculate a second set of CRI values, analyze the two sets of CRI values against a pre-existing model, estimate a physiological state (e.g., hydration, etc.) of the patient, and display the estimate on a display device. The system might also control an infusion device to infuse fluids into the patient based on estimated hydration state.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2014-11-06

Tools and techniques for estimating and/or predicting a patients current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patients blood pressure value. In particular cases, derived parameters, such as a patients compensatory reserve index (CRI) can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2014-11-14

Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2015-10-16

Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patent is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding before, during, and after fluid resuscitation, in some instances, in real-time.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2015-10-16

Novel tools and techniques are provided for assessing, predicting and/or effectiveness of cardiopulmonary resuscitation (CPR), in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid estimation of a patients compensatory reserve index (CRI) before, during, and after CPR is performed, and using the CRI and variations in CRI values to determine, in some instances, in real-time, the effectiveness of CPR that is performed.


Patent
Flashback Technologies, LLC and The Regents Of The University Of Colorado | Date: 2014-11-14

Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.96K | Year: 2013

The proposed Phase I work will deliver a noninvasive, small, portable functional pulse oximeter based finger prototype device capable of heartbeat-to-heartbeat estimation of: 1) closeness to hemodynamic decompensation of injured warfighters for the purpose of triage; 2) effectiveness of fluid resuscitation in a bleeding or a potentially bleeding patient; and, 3) fluid volume required by a bleeding patient to prevent over or under resuscitation. In addition, the device will be capable of transmitting this information wirelessly to a tablet, laptop and/or workstation. This project will also investigate the application of pulse oximeter type sensors to other areas of the body including but not limited to the forearm area, to determine optimal placement for effective and robust portable resuscitation monitoring. This work effort will utilize simulated bleeding and resuscitation data gathered at the USAISR as well as data gathered in related human hemorrhage studies involving a liter or less of blood loss, all of which are being conducted under existing Flashback projects that are synergistic to this proposed effort. The deliverables of this 6 month project will include the working resuscitation monitoring device, as well as a rigorous statistical analysis of its effectiveness based on existing data.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 1.24M | Year: 2014

Trauma related hemorrhage is a leading cause of preventable death on the battlefield. This project addresses the problem of monitoring and guidance for optimal fluid resuscitation for hemorrhage in pre-hospital and transport settings. The proposed Phase II work will deliver a CipherOx Resuscitation Monitor (CRM) ready for clinical trials for an FDA 510K submission. The CRM is a noninvasive, small, portable device that uses a pulse oximeter based finger sensor and is capable of heartbeat-to-heartbeat 1) assessment of the effectiveness of fluid resuscitation in a bleeding or a potentially bleeding patient; and, 2) estimation of how much volume blood return a patient requires to prevent over or under resuscitation. In addition, the CRM will have the capacity of storing up to two years of continuous data and be capable of transmitting resuscitation information wirelessly to a tablet, laptop and/or workstation. This provides the ability to maintain data continuity throughout the treatment of injured warfighters from the point of injury to higher echelons of care. The CRM device will be extensively tested and validated during human trials including a) lower body negative pressure hemorrhage and resuscitation studies, b) exercise studies, and c) 1 liter hemorrhage and resuscitation studies.

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