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Hasty R.T.,Campbell University | Barbato V.A.,Nova Southeastern University | Valdes Jr. P.J.,Nova Southeastern University | Powers D.W.,Nova Southeastern University | And 13 more authors.
Journal of the American Osteopathic Association | Year: 2014

Context: Since its launch in 2001, Wikipedia has become the most popular general reference site on the Internet and a popular source of health care information. To evaluate the accuracy of this resource, the authors compared Wikipedia articles on the most costly medical conditions with standard, evidence-based, peer-reviewed sources. Methods: The top 10 most costly conditions in terms of public and private expenditure in the United States were identified, and a Wikipedia article corresponding to each topic was chosen. In a blinded process, 2 randomly assigned investigators independently reviewed each article and identified all assertions (ie, implication or statement of fact) made in it. The reviewer then conducted a literature search to determine whether each assertion was supported by evidence. The assertions found by each reviewer were compared and analyzed to determine whether assertions made by Wikipedia for these conditions were supported by peer-reviewed sources. Results: For commonly identified assertions, there was statistically significant discordance between 9 of the 10 selected Wikipedia articles (coronary artery disease, lung cancer, major depressive disorder, osteoarthritis, chronic obstructive pulmonary disease, hypertension, diabetes mellitus, back pain, and hyperlipidemia) and their corresponding peer-reviewed sources (P<.05) and for all assertions made by Wikipedia for these medical conditions (P<.05 for all 9). Conclusion: Most Wikipedia articles representing the 10 most costly medical conditions in the United States contain many errors when checked against standard peer-reviewed sources. Caution should be used when using Wikipedia to answer questions regarding patient care. © 2014 American Osteopathic Association.


Brown K.C.,00 Banyan Blvd. | Bryant T.,FL | Watkins M.D.,FL
Journal of Forensic Identification | Year: 2010

This paper demonstrates two methods to produce superior photographic images by combining three to five photographs taken at different exposures. Creating high dynamic range (HDR) images in Photoshop CS4 or Photomatix Pro 3 software results in high-quality 32-bit images. HDR images can include a tonal range beyond that which can normally be captured in a single image. This technique provides the forensic examiner with more detailed images for comparisons and examinations.


Mcleod D.S.,Fl | Elefteriadou L.,University of Florida
ITE Journal (Institute of Transportation Engineers) | Year: 2012

The Florida Department of Transportation (FDOT) developed a travel time reliability model, applied it to all freeways in Florida, US, and began reporting reliability. The model and development methodology adopted by the FDOT was introduced and potential planning uses for system-wide reporting and project priority were explored. Travel time reliability had the potential to be used to analyze traffic operations and systems planning. Transportation agencies had the ability to evaluate the impact of a new incident identification and removal program over a year in systems planning and assess benefits and costs when such a program was implemented. The FDOT considered travel time reliability to be one of the primary mobility performance measures to evaluate its intelligent transportation system (ITS)program, for statewide reporting and for system-level project prioritization. FDOT had funded several research projects to develop, implement, and refine a model for predicting travel time reliability for freeways and signalized arterials.


Xue B.,FL | Xue B.,Indiana University | Oldfield C.J.,Indiana University | Van Y.-Y.,Molecular Kinetics Inc | And 4 more authors.
Molecular BioSystems | Year: 2012

Induced pluripotent stem (iPS) cells can be obtained from terminally differentiated somatic cells by overexpression of defined sets of reprogramming transcription factors. These protein sets have been called the Yamanaka factors, namely Sox2, Oct3/4 (Pou5f1), Klf4, and c-Myc, and the Thomson factors, namely Sox2, Oct3, Lin28, and Nanog. Other sets of proteins, while not essential for the formation of iPS cells, are important for improving the efficiency of the induction and still other sets of proteins are important as markers for embryonic stem cells. Structural information about most of these important proteins is very sparse. Our bioinformatics analysis herein reveals that these reprogramming factors and most of the efficiency-improving and embryonic stem cell markers are highly enriched in intrinsic disorder. As is typical for transcription factors, these proteins are modular. Specific sites for interaction with other proteins and DNA are dispersed in the long regions of intrinsic disorder. These highly dynamic interaction sites are evidently responsible for the delicate interplay among various molecules. The bioinformatics analysis given herein should facilitate the investigation of the roles and organization of these modular interaction sites, thereby helping to shed further light on the pathways that underlie the mechanism(s) by which terminally differentiated cells are converted to iPS cells.


RESULTS: Overall, 56 of 199 (28%) women suffered 70 complications, of which hematoma, skin necrosis, cellulitis, or seroma accounted for 53 (76%) of the complications. The start date of adjuvant therapy was known in 116 (58%) of the women with invasive cancer. Overall, patients that underwent immediate breast reconstruction did not have delay in adjuvant treatment when compared to patients with no reconstruction (41 days vs 42 days, P = 0.61). Women with a complication did have a significantly longer interval to adjuvant chemotherapy when compared to those with no complications (47 days vs 41 days, P = 0.027). When further stratified by type of reconstruction, although there were differences in time to adjuvant chemotherapy, none of these reached significance (tissue expanders: 45 days vs 41 days, P = 0.063; flap reconstruction: 72 days vs 49 days, P = 0.25).CONCLUSIONS: Immediate reconstruction after mastectomy does not delay additional cancer treatment. Overall, when complications do occur, adjuvant therapy is significantly delayed, though the median delay was only 6 days.BACKGROUND: Recent studies have shown that patients undergoing immediate breast reconstruction after mastectomy have a higher rate of complications relative to patients undergoing mastectomy alone. Conflicting data exist on how these complications impact adjuvant treatment. We sought to quantify the additional risk associated with immediate breast reconstruction after mastectomy and determine how these risks influence adjuvant chemotherapy.METHODS: A retrospective review of women undergoing mastectomy for breast cancer and immediate breast reconstruction between January 2007 and December 2012 was conducted. We abstracted clinicopathological variables and stratified women according to the type of reconstruction and presence of surgical complications. Additionally, time to adjuvant chemotherapy was assessed. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Khachatryan N.,University of South Florida | Heide K.M.,University of South Florida | Rad J.,University of South Florida | Hummel E.V.,Fl
Behavioral Sciences and the Law | Year: 2016

Killings by juvenile homicide offenders (JHOs) who use accomplices have been increasing since the 1980s and currently represent approximately half of juvenile arrests for murder in the United States. Nevertheless, prior research has not compared JHOs who kill alone with JHOs who kill in groups. The present research followed up 30 years later on a sample of 59 male murderers and attempted murderers sentenced to adult prison. This study was designed to analyze whether lone and group JHOs differed on pre-incarceration, incarceration, and post-incarceration variables. Significant findings indicated that compared with lone offenders, group JHOs had a higher mean of pre-homicide arrests and were more likely to be Black, have a pre-homicide delinquent record, commit a crime-related homicide offense, and target a stranger. With respect to post-homicide variables, group JHOs were more likely to be released from prison and more likely to be rearrested. The two types of JHOs did not differ significantly in relation to the number of post-release violent offenses. Preliminary implications of the findings and avenues for future investigation are discussed. © 2016 John Wiley & Sons, Ltd.


Pu R.,University of South Florida | Bell S.,University of South Florida | Levy K.H.,FL | Meyer C.,University of South Florida
International Geoscience and Remote Sensing Symposium (IGARSS) | Year: 2010

Essentially, maintenance of adequate seagrass cover is intimately related to coastal ecosystem health and thus monitoring of seagrass habitats is a priority of coastal managers. Remote sensing techniques, especially satellite remote sensing, can provide seagrass habitat information spatially and temporally. In this study, we propose to evaluate and compare the capability of four satellite sensors' (Landsat TM, EO-1 ALI and Hyperion and IKONOS) data for mapping detailed seagrass habitats. After depth-invariant bands were created from the four sensors' data, a maximum likelihood classifier was used to classify the submerged aquatic vegetation (SAV) cover percentage into 3 classes and 5 classes in the study area. The SAV mapping results indicate that Hyperion sensor has produced the best mapping results of seagrass habitats in the two classification schemes: 3-class (Overall accuracy (OAA)=96%, Kappa=0.936) and 5-class (OAA=79%, Kappa=0.730). ALI outperformed TM for mapping SAV due to its additional blue band. © 2010 IEEE.


Eck D.L.,FL | McLaughlin S.A.,FL | Terkonda S.P.,FL | Rawal B.,FL | Perdikis G.,FL
Annals of plastic surgery | Year: 2015

BACKGROUND: Recent studies have shown that patients undergoing immediate breast reconstruction after mastectomy have a higher rate of complications relative to patients undergoing mastectomy alone. Conflicting data exist on how these complications impact adjuvant treatment. We sought to quantify the additional risk associated with immediate breast reconstruction after mastectomy and determine how these risks influence adjuvant chemotherapy.METHODS: A retrospective review of women undergoing mastectomy for breast cancer and immediate breast reconstruction between January 2007 and December 2012 was conducted. We abstracted clinicopathological variables and stratified women according to the type of reconstruction and presence of surgical complications. Additionally, time to adjuvant chemotherapy was assessed.RESULTS: Overall, 56 of 199 (28%) women suffered 70 complications, of which hematoma, skin necrosis, cellulitis, or seroma accounted for 53 (76%) of the complications. The start date of adjuvant therapy was known in 116 (58%) of the women with invasive cancer. Overall, patients that underwent immediate breast reconstruction did not have delay in adjuvant treatment when compared to patients with no reconstruction (41 days vs 42 days, P = 0.61). Women with a complication did have a significantly longer interval to adjuvant chemotherapy when compared to those with no complications (47 days vs 41 days, P = 0.027). When further stratified by type of reconstruction, although there were differences in time to adjuvant chemotherapy, none of these reached significance (tissue expanders: 45 days vs 41 days, P = 0.063; flap reconstruction: 72 days vs 49 days, P = 0.25).CONCLUSIONS: Immediate reconstruction after mastectomy does not delay additional cancer treatment. Overall, when complications do occur, adjuvant therapy is significantly delayed, though the median delay was only 6 days.


PubMed | FL
Type: Journal Article | Journal: Virology | Year: 2012

The poxvirus virion contains an inner tubular nucleocapsid structure. The nucleocapsid is apparently labile to conventional electron microscopy fixation procedures and has therefore been largely ignored for decades. Advancements in electron microscopy sample preparation, notably high pressure freezing, better preserve the nucleocapsid structure. Using high pressure freezing and electron microscopy, we have compared the virion structures of wt virus and mutant viruses known to be deficient in packaging of viral transcription enzymes. We show that the mutant viruses lack a defined nucleocapsid. These results support the hypothesis that the nucleocapsid contains the viral DNA genome complexed with viral transcription enzymes and structural proteins. The studies open the door to further investigation of the composition and ultrastructure of the poxvirus nucleocapsid.


PubMed | FL.
Type: | Journal: Annals of plastic surgery | Year: 2015

Recent studies have shown that patients undergoing immediate breast reconstruction after mastectomy have a higher rate of complications relative to patients undergoing mastectomy alone. Conflicting data exist on how these complications impact adjuvant treatment. We sought to quantify the additional risk associated with immediate breast reconstruction after mastectomy and determine how these risks influence adjuvant chemotherapy.A retrospective review of women undergoing mastectomy for breast cancer and immediate breast reconstruction between January 2007 and December 2012 was conducted. We abstracted clinicopathological variables and stratified women according to the type of reconstruction and presence of surgical complications. Additionally, time to adjuvant chemotherapy was assessed.Overall, 56 of 199 (28%) women suffered 70 complications, of which hematoma, skin necrosis, cellulitis, or seroma accounted for 53 (76%) of the complications. The start date of adjuvant therapy was known in 116 (58%) of the women with invasive cancer. Overall, patients that underwent immediate breast reconstruction did not have delay in adjuvant treatment when compared to patients with no reconstruction (41 days vs 42 days, P = 0.61). Women with a complication did have a significantly longer interval to adjuvant chemotherapy when compared to those with no complications (47 days vs 41 days, P = 0.027). When further stratified by type of reconstruction, although there were differences in time to adjuvant chemotherapy, none of these reached significance (tissue expanders: 45 days vs 41 days, P = 0.063; flap reconstruction: 72 days vs 49 days, P = 0.25).Immediate reconstruction after mastectomy does not delay additional cancer treatment. Overall, when complications do occur, adjuvant therapy is significantly delayed, though the median delay was only 6 days.

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