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Schubert M.,Empa - Swiss Federal Laboratories for Materials Science and Technology | Fey A.,Empa - Swiss Federal Laboratories for Materials Science and Technology | Ihssen J.,Empa - Swiss Federal Laboratories for Materials Science and Technology | Civardi C.,Empa - Swiss Federal Laboratories for Materials Science and Technology | And 3 more authors.
Journal of Biotechnology | Year: 2015

An artificial neural network (ANN) and genetic algorithm (GA) were applied to improve the laccase-mediated oxidation of iodide (I-) to elemental iodine (I2). Biosynthesis of iodine (I2) was studied with a 5-level-4-factor central composite design (CCD). The generated ANN network was mathematically evaluated by several statistical indices and revealed better results than a classical quadratic response surface (RS) model. Determination of the relative significance of model input parameters, ranking the process parameters in order of importance (pH>laccase>mediator>iodide), was performed by sensitivity analysis. ANN-GA methodology was used to optimize the input space of the neural network model to find optimal settings for the laccase-mediated synthesis of iodine. ANN-GA optimized parameters resulted in a 9.9% increase in the conversion rate. © 2014 Elsevier B.V.


Hamel P.,Ecole Polytechnique Federale de Lausanne | Rachet B.,Ecole Polytechnique Federale de Lausanne | Werner M.,Ecole Polytechnique Federale de Lausanne | Grossenbacher M.,Ecole Polytechnique Federale de Lausanne | And 4 more authors.
Optics Letters | Year: 2011

We present an optical trapping system combining individually addressable multiple laser traps with fluorescence spectroscopy. An in-line set of 64 near-IR laser diodes is used to create a line of individually addressable traps inside a microfluidic chip. This system is completed by an excitation/detection line for spectrally resolved fluorescence imaging of trapped particles. Highly parallel trapping in a constant flow (up to a few millimeters per second), fast particle handling rates (up to a few particles per second), and the possibility of recording fluorescence spectra of trapped objects lead to a performing bioanalytical platform, e.g., for highly parallel analysis and sorting. © 2011 Optical Society of America.


Schubert M.,Empa - Swiss Federal Laboratories for Materials Science and Technology | Mourad S.,Fisba Optik AG | Schwarze F.W.M.R.,Empa - Swiss Federal Laboratories for Materials Science and Technology
Wood Science and Technology | Year: 2011

Bioincising is a promising method for enhancing liquid uptake (e.g. preservatives or wood-modification agents) in refractory wood. Incubation with the white-rot fungus, Physisporinus vitreus, which selectively degrades pit membranes, results in deeper and more homogeneous penetration of liquids. Conventional methods of assessing the degree of fungal discolouration of wood after treatment with preservatives (e.g. European standard EN 152) are partly based on a subjective rating scale, which gives a rough value of the surface colonisation by blue-stain fungi. Hence, an automated image processing (AIP) procedure was developed for standardised quantification of the segmentation thresholds of discolouration and tested against manual segmentation analysis. Using the red filter in the AIP method revealed high correlation (R 2 0.95) and allowed for more user friendly and objective determination of blue staining of wood. © 2010 Springer-Verlag.


Fahnle O.,Fisba Optik AG | Hauser K.,Fisba Optik AG
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2011

Shaping processes, e.g. cnc grinding, loose abrasive grinding and fluid jet polishing have been investigated experimentally for the level of sub-surface damage caused analyzing dif-ferent process characteristics. © 2011 SPIE.


Lipp M.,Fisba Optik AG | Langenbach E.,Fisba Optik AG | Saupe F.,Fisba Optik AG
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2014

Methods for thermal modeling, analysis and optimization are presented. Modeling distinguishes between three basic types of lens mounts. For analysis also FEA-results are incorporated in the optical model. Optimization with a simple, glass substitution method and a paraxial method is presented. © 2014 SPIE.

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