First Peoples Hospital of Yinchuan
First Peoples Hospital of Yinchuan
Jiao K.-P.,Peoples Hospital of Gansu Province |
Li S.-M.,First Peoples Hospital of Yinchuan |
Lv W.-Y.,PLA Hospital of China |
Jv M.L.,Shanghai JiaoTong University |
He H.Y.,Shanghai JiaoTong University
NeuroReport | Year: 2017
Vitamin D3 has been reported to be an immunity modulator and high levels of vitamin D3 are correlated with a decreased risk for developing diseases in the central nervous system. Astrocytes are important immune cells and contribute toward inflammation during neurological diseases. The vitamin D receptor has been reported to be expressed in astrocytes; however, the effect of vitamin D3 on astrocyte activation has not been studied. Here, we found that lipopolysaccharide stimulation in astrocytes could enhance the expression of vitamin D receptor and Cyp27B1, which encodes the enzyme for converting vitamin D3 into its active form. Vitamin D3 suppressed the expression of proinflammatory cytokines tumour necrosis factor-a, interleukin-1ß, vascular endothelial growth factor, and also TLR4 in activated astrocytes. Astrocyte activation was further found to be suppressed after the administration of vitamin D3 in neonatal rats injected with lipopolysaccharide in vivo. We demonstrated the antiactivation effect of vitamin D3 in astrocytes after lipopolysaccharide stimulation. Considering the function of reactive astrocytes in augmenting inflammatory response in neurodegeneration and brain injury, the finding that vitamin D3 administration may inhibit astrocyte activation may be potentially useful for the treatment of central nervous system disorders. © Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved.
Cao Y.,Shanghai University of Traditional Chinese Medicine |
Zhuang M.-F.,Shanghai University of Traditional Chinese Medicine |
Yang Y.,First Peoples Hospital of Yinchuan |
Xie S.-W.,Shanghai Institute of Planned Parenthood Research |
And 4 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2014
In this study, the endometriosis rats model was randomly divided into 6 groups: model control group, ovariectomized group, Gestrinone group, and quercetin high/medium/low dose group. Rats were killed after 3 weeks of administration. The expression levels of serum FSH and LH were detected by ELISA. The localizations and quantities of ERα, ERβ, and PR were detected by immunohistochemistry and western blot. The results showed that the mechanism of quercetin inhibiting the growth of ectopic endometrium on rat endometriosis model may be through the decreasing of serum FSH and LH levels and then reducing local estrogen content to make the ectopic endometrium atrophy. Quercetin can decrease the expression of ERα, ERβ, and PR in hypothalamus, pituitary, and endometrium, thereby inhibiting estrogen and progesterone binding to their receptors to play the role of antiestrogen and progesterone. © 2014 Yang Cao et al.
Wu X.,First Peoples Hospital of Yinchuan |
Jia W.,First Peoples Hospital of Yinchuan |
He J.,First Peoples Hospital of Yinchuan |
Chen F.,First Peoples Hospital of Yinchuan |
And 4 more authors.
Experimental and Clinical Cardiology | Year: 2014
A unicuspid aortic valve is a rare pathology among congenital heart diseases that requires cardiac surgery and is often confused with a bicuspid valve. The incidence of unicuspid aortic valve on echocardiography was reported to be 0.02% in adults. It usually presents with aortic stenosis and/or aortic regurgitation. Other cardiovascular complications, such as aortic dilatation, patent ductus arteriosus, coarctation of aorta, ventricular septal defect, and left ventricular hypertrophy, can accompany it. Herein, we present a case report of a 33-year-old asymptomatic male patient with a unicuspid aortic valve complicated by coarctation of the aorta and an ascending aorta aneurysm. The first stage operation, bypass with an artificial blood vessel between the right axillary artery and right femoral artery combined with aortic valve repair using the tricuspidization technique and aortic arch wrapping, was successful. During the surgery, the valve was found to be an acommissural unicuspid aortic valve without significant calcification and thickening. A second stage operation of a distal arch to descending thoracic aorta bypass was followed, successfully without complication.
Zhang D.,First Peoples Hospital of Yinchuan |
Du N.,First Peoples Hospital of Yinchuan |
Liu Y.,First Peoples Hospital of Yinchuan |
Zhang X.,First Peoples Hospital of Yinchuan |
Wang S.,First Peoples Hospital of Yinchuan
Shanghai kou qiang yi xue = Shanghai journal of stomatology | Year: 2013
PURPOSE: To observe the effect of subcutaneous ectopic osteogenesis using different proportional mixtures of hydroxyapatite (HAP) and human mandible in nude mice.METHODS: After obtaining external oblique ridge of mandible, autologous bone was mixed with HAP according to certain proportion. The mixtures were divided into 5 groups (group A: autologous bone/HAP=2/1; Group B: autologous bone/HAP=1/1; Group C: autologous bone/HAP=1/2; Group D: autologous bone/HAP=a quarter; Group E: HAP). The 5 groups of mixtures were respectively implanted into nude mice subcutaneously. After 8 weeks, the specimens were obtained and hard tissue sections were completed. The new bone formation was measured after trinitrophenol staining. The data was analyzed with SPSS 13.0 software package.RESULTS: The hard tissue section showed that new ectopic bone formation area was 9.1% (Group A), 16.1% (Group B), 6.1% (Group C), 3.8% (Group D), and 1.3% (Group E), respectively. New bone formation was the most in group B, while it was the least in group E. Significant differences were found between group B and other groups(P<0.05). However, there was no significant difference between group E and group C or D (P>0.05). The retention rate of HAP was the most in group E (30.3%) and the least (16.3%) in group A.CONCLUSIONS: During 8 weeks, human autologous bone mixed with HAP helps new bone formation in nude mice. The best ratio autologous bone and HAP was 1:1. This study provides certain reference basis for dentist to make lifting surgery outside the maxillary sinus using artificial bone graft. Supported by Science and Technology Project of Ningxia Hui Autonomous Region (2011zys271).
Zhang Y.,Ningxia Medical University |
Dou C.,First Peoples Hospital of Yinchuan |
Wang Y.,Ningxia Medical University
Applied Surface Science | Year: 2011
Based on ambient atmosphere scanning tunneling microscope (STM) technique, scanning tunneling spectroscopy (STS) combined with statistics analysis was developed to investigate the single-molecule conductance of various kinds of molecules which were self-assembled on the Au (1 1 1). Conductance histograms obtained from current-voltage curves revealed well-defined peaks at integer multiples of a fundamental conductance and were used to identify the conductance of a single molecule. The conductances of saturated molecules like 1,8-octanedithol and hexanethiocyanate were found to be 0.072 × 10 -4G0 and 0.06 × 10-4G0 respectively and 0.23 × 10-4G0 and 0.13 × 10-4G0 for unsaturated molecules like 5,5′-dithiol- 2,2′,5′,2″-terthiophene and 4,4′-dithio-tert(phenylene ethylene). © 2011 Elsevier B.V. All rights reserved.