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Cao C.,University of Sichuan | Liu S.,First Peoples Hospital of Yibin | Lou S.-F.,Chongqing Medical University | Liu T.,University of Sichuan
European Review for Medical and Pharmacological Sciences | Year: 2014

BACKGROUND AND OBJECTIVES: Many studies have shown that the +252A/G polymorphism in the lymphotoxin-α gene is implicated in susceptibility to non-Hodgkin lymphoma but with considerable variance of results. This study aimed to clarify the overall association between the +252A/G polymorphism in the lymphotoxin-α gene and non-Hodgkin lymphoma (NHL) risk by performing a meta-analysis. MATERIALS AND METHODS: The Pubmed and Embase databases were searched for all studies relating to lymphotoxin-α +252A/G gene polymorphism and NHL risk. Data were retrieved and statistical analyses were performed using the Revman 5.1 and STATA 12.0 software. RESULTS: Fourteen case-control studies with 25,098 subjects were included. There was no significant association between lymphotoxin-α +252A/G gene polymorphism and the risk of NHL in the all-combined analysis (OR = 1.08, 95%CI: 0.98-1.19 for GG+GA vs. AA; OR = 1.05, 95%CI: 0.95-1.25 for GG vs. GA+AA). In a subgroup analysis by ethnicity, increased NHL risk was found in North Americans (OR = 1.21, 95%CI: 1.05-1.39 for GG+GA vs. AA), no significant association with NHL risk was identified in Asians or Europeans; In a subgroup analysis by NHL subtype, a significantly increased risk was identified in diffuse large B cell lymphoma patients (OR = 1.20 95%CI: 1.11-1.29 for GG+GA vs. AA), but not for follicular lymphoma. CONCLUSIONS: This meta-analysis suggested that the lymphotoxin-α +252A/G gene polymorphism is a risk factor for NHL in North Americans, and this polymorphism may contribute to diffuse large B cell lymphoma susceptibility. Future studies that include different types of NHL and ethnicities are needed to support and extend these observations. Source

Li J.,University of Sichuan | Mao H.,First Peoples Hospital of Yibin | Liang Y.,University of Sichuan | Lu Y.,University of Sichuan | And 3 more authors.
Clinical and Developmental Immunology | Year: 2013

All randomized controlled trials (RCTs) of iguratimod for rheumatoid arthritis (RA) to assess its efficacy and safety are included in this paper. The Review Manager software was used for meta-analysis to assess risk bias of the studies included, and GRADE profiler software was used for the evidence quality of the studies included. Four RCTs involving 1407 patients with RA were included. Meta-analyses showed that, after 24-week therapy, ACR20, tender joint count, swollen joint count, rest pain, physician and patient global assessment of disease activity, HAQ score, ESR, and CRP in iguratimod group were better than those in placebo group and that the difference between those of iguratimod group and those of other DMARDs (MTX and SASP) group was not significant. GRADE evidence classification of the studies included was moderate. Iguratimod for RA had few adverse events, and its efficacy and safety were the same as those of MTX and SASP for RA. The results of this systematic review suggest that more high-quality and large-scaled RCTs were needed to determine the efficacy of iguratimod for RA and whether iguratimod is as effective as other DMARDs besides MTX and SASP. © 2013 Jiangtao Li et al. Source

Chen H.,Yibin University | Lin Z.,Yibin University | Wu H.,First Peoples Hospital of Yibin | Wang L.,Yibin University | And 2 more authors.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2015

Near-infrared (NIR) spectroscopy has such advantages as being noninvasive, fast, relatively inexpensive, and no risk of ionizing radiation. Differences in the NIR signals can reflect many physiological changes, which are in turn associated with such factors as vascularization, cellularity, oxygen consumption, or remodeling. NIR spectral differences between colorectal cancer and healthy tissues were investigated. A Fourier transform NIR spectroscopy instrument equipped with a fiber-optic probe was used to mimic in situ clinical measurements. A total of 186 spectra were collected and then underwent the preprocessing of standard normalize variate (SNV) for removing unwanted background variances. All the specimen and spots used for spectral collection were confirmed staining and examination by an experienced pathologist so as to ensure the representative of the pathology. Principal component analysis (PCA) was used to uncover the possible clustering. Several methods including random forest (RF), partial least squares-discriminant analysis (PLSDA), K-nearest neighbor and classification and regression tree (CART) were used to extract spectral features and to construct the diagnostic models. By comparison, it reveals that, even if no obvious difference of misclassified ratio (MCR) was observed between these models, RF is preferable since it is quicker, more convenient and insensitive to over-fitting. The results indicate that NIR spectroscopy coupled with RF model can serve as a potential tool for discriminating the colorectal cancer tissues from normal ones. © 2014 Elsevier B.V. All rights reserved. Source

He M.-M.,Guangzhou Medical College | Liu Z.-F.,First Peoples Hospital of Yibin | Wang X.-D.,University of Sichuan
Journal of Sichuan University (Medical Science Edition) | Year: 2011

Objective: To investigate the stereological changes of placental lobular villi vessels in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: Stereological analysis on vessels volume and cross-areas of placental samples taken from 10 normal and 10 ICP patients at 37-40 week pregnancy were performed. Results: Compared with normal pregnancy, the ICP patients had 29% reduction in the volume of placental lobular villi vessels [(287. 81±69. 81) mL vs. (203. 63±41. 29) mL]: 21% reduction in the cross-areas [(617119. 5± 158422. 65) μm 2 vs. (485087. 6± 104707. 63) μm 2]; but no change in the numbers [(313. 40±137. 51) vs. (365. 20±96. 73)] of lobular villi vessels (P>0. 05). Similarly, significant decreases in the volume [(131. 98±84. 68) mL vs. (55.98 ±21.08] mL) and cross-areas [(271809. 6± 162354. 35) μm 2 vs. (127576. 2±54897. 44) μm 2) of placental lobular villi vessels with smooth muscles in the ICP patients were also found (P<0. 05). But the volume [(161. 48 ± 75.80) mL vs. (155. 91±30. 52) mL] and cross-areas [(342639. 6± 145717. 51) μm 2 vs. (341849. 3±57043. 88) μm 2] of placental lobular villi vessels without smooth muscle in the ICP patients remained unchanged (P>0. 05). The placental lobular villi vascular volume was negatively correlated (r= -0. 413) with the maternal plasma level of total bile acid (TBA) (P>0. 05), and positively correlated (r=0. 302) with the onset week of ICP (P>0. 05). But the correlations were not statistically significant. Conclusion: Patients with ICP have 29% reduction in placental lobular villi vascular volume, which is mainly a result of reduction of lobular villi vessels with smooth muscles. The placental lobular villi vascular volume is possibly negatively correled with maternal plasma level of TBA, and positively correled with the onset week of ICP. Source

Huang G.,University of Sichuan | Liu Z.,First Peoples Hospital of Yibin | He M.,Guangzhou Medical College | Wang X.,University of Sichuan
Gynecologic and Obstetric Investigation | Year: 2014

Objective: Intrahepatic cholestasis of pregnancy (ICP) may lead to sudden onset of stillbirth, which most likely is related to uteroplacental insufficiency and dysregulation of the fetal blood supply. The relaxing effect of corticotropin-releasing hormone (CRH) on blood vessels was measured to examine the role of CRH in the pathogenesis of ICP. Methods: Eighty normal pregnant women and 80 ICP patients were divided into four groups of 20 cases, respectively, each based on gestational age from week 34 to 37. Radioimmunoassay was used to measure CRH in plasma samples collected from all of the subjects. Results: Plasma CRH increased markedly from week 34 to 37 in both ICP and healthy patients, but the increase was lower in the ICP group. Plasma CRH was 322 ± 61 pg/ml in mild ICP cases at 37 weeks' compared to 1,066 ± 173 pg/ml in controls (p < 0.05), but only 218 ± 128 pg/ml in severe ICP (p < 0.05). Plasma CRH was significantly lower at all other measured time points in patients with severe ICP. In ICP patients, there was a negative correlation between plasma CRH and total bile acid (TBA). Conclusion: A limited increasing CRH level and negative correlation of CRH with TBA were unveiled in ICP patients. © 2014 S. Karger AG, Basel. Source

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