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Gu S.-J.,First peoples Hospital of Xiaoshan District of Hangzhou City | Xuan H.-F.,First peoples Hospital of Xiaoshan District of Hangzhou City | Lu M.,First peoples Hospital of Xiaoshan District of Hangzhou City | Chen X.-Z.,First peoples Hospital of Xiaoshan District of Hangzhou City | And 6 more authors.
Clinica Chimica Acta | Year: 2013

Background: Visfatin, a proinflammatory mediator, has been associated with poor clinical outcomes after acute brain injury. The present study is designed to investigate the potential association between plasma visfatin levels and the risk of hematoma growth (HG) and early neurologic deterioration (END) after intracerebral hemorrhage. Methods: There were 85 patients as cases who presented with first-time hemorrhagic stroke that were assessed within 6. h after the incident. The control group consisted of 85 healthy volunteers. HG was defined as hematoma enlargement >. 33% at 24. h. END was defined as an increase of. ≥. 4 points in National Institute of Health Stroke Scale score at 24. h from symptoms onset. Plasma visfatin levels were determined using enzyme immunoassay. Results: Plasma visfatin levels were significantly higher in patients compared to controls. Plasma visfatin level emerged as an independent predictor of HG [odds ratio (OR), 1.154; 95% confidence interval (CI), 1.046-3.108; P=. 0.009] and END (OR, 1.195; 95% CI, 1.073-3.516; P=. 0.005). For predicting HG, area under curve (AUC) of plasma visfatin level (0.814; 95% CI: 0.715-0.890) was similar to that of hematoma volume (0.839; 95% CI, 0.743-0.909) (. P=. 0.703). For predicting END, AUC of plasma visfatin level (0.828; 95% CI: 0.730-0.901) was similar to that of hematoma volume (0.863; 95% CI, 0.771-0.928) (. P=. 0.605). Visfatin did not improve AUC of hematoma volume for predicting HG and END (both P>. 0.05). Conclusion: Plasma visfatin level represents a novel biomarker for predicting HG and END. © 2013 Elsevier B.V.

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