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Lin H.,First Peoples Hospital of Wenling | Pan E.-C.,U.S. Center for Disease Control and Prevention | Shan H.-S.,Bengbu Medical College | Wen X.-Y.,Bengbu Medical College | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2014

OBJECTIVE: To investigate the incidence and distribution characteristics of cancer in Huai'an during the period of 2009-2011 for prevention and control of the disease. METHODS: Based on demography and death data collected through Huai'an's Disease Surveillance System, 2009-2011, the incidence rate, age-standardized rate and cumulative rate as well as the distribution characteristics of cancer in Huai'an were analyzed. RESULTS: The incidence rate and age-standardized rate of cancer were 205.60/105 and 166.22/105, the crude and standardized rates of man were higher than that of women, the incidence gradually increased with age over 40 years old, the highest peak was in the age of 70-75 years old. The top 10 most common cancer sites in Huai'an area during the 3-year period in order were esophagus, stomach, lung (including trachea and bronchus), liver, colon-rectum (including anus), breast, pancreas, cervix uteri, brain and CNS and leukemia, which accounted for 87.56% of all cancers. The incidence rate of esophageal cancer was 62.91/105, accounting for 30.60% of all cancers. It was located in the first onset in male, female, city and rural population. CONCLUSIONS: Cancer is one kind of major diseases threatening people's health in Huai'an area and a major threats to the elderly population. Although the incidence of malignant tumor is lower than that in the national average level, but from a single disease situation, esophageal cancer had a high incidence. Cancer prevention and control should be enhanced, especially for esophageal cancer. Source


Dai D.-P.,Beijing Institute of Geriatrics | Hu L.-M.,First Peoples Hospital of Wenling | Geng P.-W.,Laboratory of Clinical Pharmacy | Wang S.-H.,Laboratory of Clinical Pharmacy | And 4 more authors.
Xenobiotica | Year: 2015

1. CYP2C19 is a highly polymorphic enzyme responsible for the metabolism of a wide range of clinical drugs. Alterations to the CYP2C19 gene contribute to the variability of CYP2C19 enzyme activity, which causes pharmacokinetics and drug efficacies to vary and adverse drug reactions to occur in different persons. Recently, we identified 24 novel CYP2C19 allelic variants in the Chinese Han population. The purpose of present study is to assess the impact of these newly found nucleotide mutations on the enzymatic activity of the CYP2C19 protein.2. Dual-expression vectors were constructed and transiently transfected into 293FT cells. Forty-eight hours after transfection, cells were re-suspended and incubated with two typical probe substrates, omeprazole and S-mephenytoin, to determine the activities of each variant relative to the wild-type protein.3. Immunoblotting results showed that the protein expression levels of the CYP2C19 variants were diverse. Enzymatic ability analysis showed that the variant 35FS exhibited no functional activity, and most of the other variants showed significantly decreased metabolic activities toward both omeprazole and S-mephenytoin compared with wild-type.4. These findings greatly enrich the knowledge of biological effects of these newly found CYP2C19 mutations and aid the application of this knowledge to future individualized drug therapy in clinic. © 2015 Informa UK Ltd. Source


Li X.-L.,First Peoples Hospital of Wenling | Zheng Z.-J.,First Peoples Hospital of Wenling | Qu H.-O.,First Peoples Hospital of Wenling
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | Year: 2015

Objective: Previous case-control studies on the relation between angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and breast cancer did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the ACE gene I/D polymorphism and breast cancer. Methods: We selected 13 case-control studies related to ACE gene I/D polymorphism and breast cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, Chinese CNKI, and Wanfang database. To test the heterogeneity between each study, we utilized the Q-test and I2 test. To merge the odds ratio (OR) and 95% confidence interval (CI), we utilized the random effects model during the analyses. Results: The present study included 1997 patients with breast cancer and 8404 cancer-free control subjects. By metaanalysis, we did not find any association of ACE gene I/D polymorphism with breast cancer in different model (DD vs (ID+II): OR=1.28, 95% CI (0.90-1.81), p=0.16; II vs (ID+DD): OR=0.99, 95% CI (0.81-1.21), p=0.93; D allele vs I allele: OR=1.15, 95% CI (0.94-1.41), p=0.18). Conclusion: We concluded that ACE gene I/D polymorphism was not associated with breast cancer. © The Author(s) 2014. Source


Wang W.-J.,First Peoples Hospital of Wenling | Chen J.-Z.,First Peoples Hospital of Wenling | Fang Q.,First Peoples Hospital of Wenling | Li J.-F.,First Peoples Hospital of Wenling | And 2 more authors.
Journal of Laparoendoscopic and Advanced Surgical Techniques | Year: 2013

Objective: To compare the effects of laparoscopic inguinal hernia repair (LIHR) and Lichtenstein tension-free inguinal hernia repair and to explore the safety and feasibility of LIHR as well as the advantages and disadvantages of these procedures. Subjects and Methods: In total, 252 patients with inguinal hernia were equally randomized into the transabdominal preperitoneal (TAPP) repair, totally extraperitoneal (TEP) repair, and Lichtenstein tension-free hernia repair groups (n=84 each). Operating time, postoperative pain scores, postoperative scrotal seroma, postoperative local esthesiodermia, postoperative chronic pains, postoperative long-term hernia relapse, and costs of hospitalization were compared among the three groups. Results: All laparoscopic operations were performed smoothly without intraoperative conversion to open surgery. The LIHR groups showed significantly better effects on postoperative pains and hernia recurrence than the Lichtenstein tension-free herniorrhaphy group (P<.05), but with a significantly higher hospitalization cost (P<.05). The occurrence rate of postoperative scrotal seroma or hydrops in the TAPP, TEP, and Lichtenstein groups was 11 (13.10%), 13 (15.48%), and 6 (7.14%), respectively. No significant differences among the operating time, postoperative local esthesiodermia, or postoperative chronic pains of the groups were observed (P>.05). Conclusions: LIHR is a safe and feasible procedure. It has significantly better effects on postoperative pains and hernia relapse than Lichtenstein tension-free hernia repair. © Mary Ann Liebert, Inc. Source

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