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Xiong X.-B.,First Peoples Hospital of Jingzhou | Cheng X.-L.,First Peoples Hospital of Jingzhou | Xiang M.-Q.,First Peoples Hospital of Jingzhou
Journal of Clinical Neurology | Year: 2010

Objective: To explore the influence of Edaravone on tumor necrosis factor(TNF)-α and interleukin (IL)-1β expression at hippocampus in epileptic rats. Methods: Thirty-six Wistar rats were randomly divided into Edaravone group, epilepsy group and normal control group. Epilepsy models of rats were prepared with intraperitoneal injection of pentylenetetrazol. Edaravone group were intraperitoneally injected Edaravone(3 mg/kg) at 0.5 h before, right after and 12 h after the operation. The behaviour of epileptic rats was observed. And the expressions of TNF-α and IL-1β at hippocampus in all the rats were detected by enzyme linked immunosorbent assay (ELISA). Results: After operation, all the 12 rats of epilepsy group were at stage V seizure; while in Edaravone group, 3 rats were at stage V seizure, 2 rats were at stage IV seizure, 5 rats were at stage III seizure,2 rats were at stage II seizure. Compared with normal control group, the expressions of TNF-α and IL-1β in Edaravone group and epilepsy group were significantly increased (P < 0.05-0.01). Compared with epilepsy group, the expressions of TNF-α and IL-1β in Edaravone group were significantly decreased (all P <0.01). Conclusion: Edaravone can remarkably decrease the expression of TNF-α and IL-1β at hippocampus in epileptic rats, which results in anti-epilepsy effect. Source


Hou X.,First Peoples Hospital of Jingzhou | Zhang P.,First Peoples Hospital of Jingzhou | Nie W.,Shanghai Changzheng Hospital | Tang S.,First Peoples Hospital of Jingzhou | And 5 more authors.
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | Year: 2015

Background: Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin- converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality. Methods: A comprehensive literature search was performed. Six casecontrol studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using randomeffects models. Results: Pooled analysis of six casecontrol studies showed that there was a significant association between the angiotensin- converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.620.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.571.24, p = 0.38). Conclusions: Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality. © 2015 The Author(s). Source

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