First Peoples Hospital of Hefei City

Hefei, China

First Peoples Hospital of Hefei City

Hefei, China
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Qin H.-L.,First Peoples Hospital of Hefei City | He K.-W.,First Peoples Hospital of Hefei City | Bin G.,First Peoples Hospital of Hefei City
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: At present, there is no effective drug for the treatment of diabetic arteniosclerosis obliterons, and most of the patients have to receive amputation, and have poor prognosis. OBJECTIVE: To treat the diabetic foot with human umbilical cord mesenchymal stem cells transplantation combined with angioplasty, and to perform the angiographic evaluation at 3 months after operation. METHODS: Forty cases (52 limbs) diagnosed with severe symptoms of Fontain IV diabetic foot accompanied with varying degrees of lower extremity arterial disease were included. The 12 cases (18 limbs) in the control group received simple interventional treatment, and 28 cases (34 limbs) in the experimental group were given human umbilical cord mesenchymal stem cells endovascular infusion and injection around the ulcer. Then all the patients were followed-up for 3 months. RESULTS AND CONCLUSION: Local cool-feeling, pain and numbness after treatment were improved continuously in a certain extent; skin temperature, ankle-brachial pressure index and claudication distance were improved persistently. Re-examination angiography at 3 months after treatment showed that the neovessels were increased significantly and the ulcer was healed or decreased gradually. No serious complications and adverse reactions were observed before and after infusion. The results indicate that human umbilical cord mesenchymal stem cell transplantation combined with angioplasty is a safe, effective and satisfactory method for severe diabetic foot.


Qin H.-L.,First Peoples Hospital of Hefei City | Gao Bin.,First Peoples Hospital of Hefei City
Journal of Interventional Radiology | Year: 2010

Because the distal arteries of lower extremities become narrowed or even occluded in diabetic foot, the clinical therapeutic results for diabetic foot have been unsatisfactory so far. Autologous stem cell transplantation that has emerged in recent years is a new, safe and effective therapy for diabetic foot, which achieves its excellent clinical success in restoring the blood supply of ischemic limb by way of therapeutic angiogenesis. Now autologous stem cell transplantation has become one of the hot points in medical research both at home and abroad, moreover, it has brought a new hope of cure to the patients with diabetic foot.


Xie Y.-J.,Anhui Medical University | Wang A.-L.,Anhui Medical University | Guo Z.,Anhui Medical University | Li C.-S.,First Peoples Hospital of Hefei City | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Bone marrow mesenchymal stem cells (BMSCs) transplantation can promote cardiac repair after myocardial infarction, but it has been limited by the low cell survival rate. Objective: To study the effect of hydrogen sulfide (H2S) on the BMSCs transplantation for treatment of myocardial infarction. Methods: BMSCs were separated and cultivated form Sprague-Dawley rats weighing (100±20) g. The 4th generation cells were used for later experiment, and marked by DAPI at 2 hours before use. Fifty male Sprague-Dawley rats, weighing (200±20) g had been divided into five groups: Sham group (n=10) and four transplantation groups: BMSCs (n=10), H2S-BMSCs (n=10), H2S (n=10), normal saline (n=10). The myocardial infarction model of four groups was established except of sham group (only thread without ligation). The cardiac function was measured by echocardiogram at 4 weeks after cell transplantation. The collagen in the infarction area was tested by Masson staining. Results And Conclusion: Severe myocardial fibrosis was found in the normal saline group, with no myocardial regeneration in the infarct area. H2S-BMSCs group had less collagen and more cardiac muscle tissue than BMSCs or H2S groups. Left ventricular ejection fraction and left ventricular fractional shortening of the H2S-BMSCs group were significantly higher than those of the BMSCs or H2S groups (P < 0.05). The cells survival rate and cardiac function of myocardial infarction rats can be promoted by H2S-preconditioned BMSCs transplantation, which is superior to BMSCs or H2S alone.

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