Guo L.,The First Peoples Hospital of Chenzhou City |
Lu W.,The First Peoples Hospital of Chenzhou City |
Zhang X.,The First Peoples Hospital of Chenzhou City |
Luo D.,The First Peoples Hospital of Chenzhou City |
Zhang H.,Central South University
International Journal of Clinical and Experimental Pathology | Year: 2014
Aims: To investigate metastasis associated in colon cancer 1 (MACC1) expression in cervical cancer. Methods: One hundred and four paraffin-embedded cervical cancer specimens were immunohistochemically analyzed for MACC1 expression. The expression of MACC1 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Results: MACC1 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Patients with higher MACC1 expression had shorter overall survival time, whereas those with lower ASAP1 expression survived longer (P = 0.029). Moreover, high expression of MACC1 was correlated with FIGO stage (P = 0.039) and lymph nodes metastasis (P = 0.003) of this disease. Multivariate analysis revealed that MACC1 was an independent prognostic factor (P = 0.043) for the overall survival of cervical cancer patients. Conclusion: Our study suggests that MACC1 may contribute to tumor development and progression in cervical cancer, and that MACC1 could be a useful marker for the prognosis of cervical cancer.
Wen H.,The First Peoples Hospital of Chenzhou City |
Tang J.,The First Peoples Hospital of Chenzhou City |
Liu B.,The First Peoples Hospital of Chenzhou City |
Sun C.,The Tumour Hospital of YunnanProvince
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology | Year: 2015
OBJECTIVES: To investigate the expression and clinical significance of BATF2 in the oral tongue squamous cell carcinoma (OTSCC).METHODS: Expression of BATF2 mRNA and protein in 16 paired OTSCC tissues and adjacent non-tumor mucosa were examined using quantitative PCR, western blotting analysis and immunohistochemistry assays, and the relation between BATF2 expression and clinical pathologic factor and prognosis was analyzed.RESULTS: In 16 paired tissues, expression of BATF2 mRNA in 13 OTSCC tissues and expression of BATF2 protein in 14 OTSCC tissues were significantly lower than that in adjacent non-tumor mucosa. In 202 paraffin-embedded OTSCC samples, BATF2 was not expressed in 20 cases (9.9%), low expressed in 104 cases (51.5%) and highly expressed in 78 (38.6%). BATF2 expression level was significantly correlated with histological differentiation (P = 0.002). Patients with low BATF2 expression had significantly poorer overall survival and disease-free survival than those with high BATF2 expression (P < 0.001).CONCLUSIONS: BATF2 was low expressed in OTSCC and related to tumor differentiation and prognosis and may serve as a prognostic biomarker and potential therapeutic target for this disease.
Xie L.-L.,The First Peoples Hospital of Chenzhou City |
Zhu J.-D.,The First Peoples Hospital of Chenzhou City |
Zhou X.-P.,The First Peoples Hospital of Chenzhou City |
Chen S.-Y.,The First Peoples Hospital of Chenzhou City
International Journal of Ophthalmology | Year: 2011
AIM: To study the effect on high myopia accompanied with cataract treated by phacoemulsification and implantation of the low dimensionality posterior chamber intraocular lens (IOL). METHODS: Eighty cases 100 eyes of high myopia accompanied with cataract whose mean axis oculi was 30.55mm received phacoemulsification and IOL implantation. We used sclera tunnel incision and phacoemulsification debulk. Preoperative axial length, preoperative visual acuity and postoperative visual acuity were recorded. Intraoperative and postoperative complications were observed. The follow-up time was from 3 to 12 months. RESULTS: There were 51 eyes (51.0%) whose best-corrected visual acuity exceeded 0.5 three months postoperatively. The operative complications were the rupture of posterior capsule 2 eyes, dislocation of lens 2 eyes. The postoperative complications were corneal endothelial edema 9 eyes, after cataract 2 eyes, retinal detachment 1 eye. CONCLUSION: Phacoemulsification has many merits such as small incision and low astigmia. Phacoemulsification and implantation of the low dimensionality posterior chamber IOL used to treat high myopia accompanied with cataract can prevent complication and recover the visual function.