First Peoples Hospital Of Chengdu

Chengdu, China

First Peoples Hospital Of Chengdu

Chengdu, China
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Min P.,First Peoples Hospital Of Chengdu | Peng Y.X.,First Peoples Hospital Of Chengdu | Hu J.H.,First Peoples Hospital Of Chengdu | Gu Z.C.,First Peoples Hospital Of Chengdu
Chinese Journal of Tissue Engineering Research | Year: 2015

Background: Total knee arthroplasty is always associated with peripheral blood loss. Blood transfusion not only involves additional cost and prolongs rehabilitation time, but also carries substantial risk of immunologic reaction and disease transmission. Therefore it is very important to reduce blood loss of total knee arthroplasty. Objective: To investigate the efficacy and safety of tranexamic acid on reducing blood loss after total knee arthroplasty. Methods: We enrolled 64 patients with primary osteoarthritis undergoing a unilateral total knee arthroplasty and randomized them into two groups, with 32 patients in each group. Tranexamic acid group: patients received intravenous drop infusion of tranexamic acid dissolved in 250 mL normal saline (10 mg/kg) at 15 minutes before operation; control group: patients just received 250 mL normal saline. Intraoperative blood loss, postoperative blood loss, postoperative hemoglobin levels, amount of blood transfusion, and number of patients requiring blood transfusion were compared. Fibrinogen, prothrombin time and other coagulation indicators were also examined before operation and 3 hours after operation. Deep vein thrombosis in both limbs of all patients was examined by the color Doppler ultrasonography 30 days after operation. Results and Conclusion: There was no significant difference in intraoperative blood loss between the two groups (P > 0.05). Postoperative volume of blood loss was lower in the tranexamic acid group than in the control group (P < 0.001). The amount of blood transfusion and number of patients requiring blood transfusion were lower in the tranexamic acid group than in the control group (P < 0.001). The postoperative hemoglobin levels were obviously higher in the tranexamic acid group than in the control group (P < 0.001). There was no significant difference in coagulation indicators between two groups at postoperative 3 hours, but D-dimer value in the two groups was significantly higher than that before surgery, and the tranexamic acid group was lower than the control group (P < 0.001). No cases appeared deep vein thrombosis after operation. Experimental findings indicate that, tranexamic acid can effectively reduce postoperative blood loss and blood transfusion, as well as number of blood transfusions after total knee arthroplasty. And it did not increase the risk of deep vein thrombosis. © 2015 Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Liu C.-J.,First Peoples Hospital Of Chengdu | Gu Z.-C.,First Peoples Hospital Of Chengdu | Zhang Y.,First Peoples Hospital Of Chengdu
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Posterior lumbar pedicle screw fixation has been a common method to treat vertebral compression fractures. Traditional surgical incision of pedicle screw fixation commonly produces many local muscle tissue damages. Lumbar fixation by minimally invasive method is a big progress in minimally invasive spine surgery. OBJECTIVE: To investigate the therapeutic results of Sextant system with percutaneous pedicle screw fixation for the treatment of lumbar fracture, and to compare the changes in visual analog scale, the ratio of anterior to posterior border height of the injured vertebra, and kyphosis Cobb angle before and after fixation. METHODS: Data of 58 cases of vertebral compression fractures were retrospectively analyzed. All cases were treated by the senior associate chief physician (second author) at the Department of Orthopedics, the First People’s Hospital of Chengdu from January 2008 to December 2013. They received Sextant system with percutaneous pedicle screw fixation. Intraoperative blood loss, the changes in visual analog scale, the ratio of anterior to posterior border height of the injured vertebra, and kyphosis Cobb angle before and after fixation were observed. RESULTS AND CONCLUSION: The average blood loss during the surgery was 40 mL, with an average post-surgery drainage of 80 mL. Postoperative lumbar back pain was significantly reduced (P < 0.01). After 2 weeks of lying in bed, they could do early functional rehabilitation exercises. The ratio of anterior to posterior border height of the injured vertebra, and kyphosis Cobb angle were significantly improved after fixation (P < 0.05). There was no screw loosening or breakage. These data suggested that the Sextant system with percutaneous pedicle screw fixation for vertebral compression fractures can better restore the anterior border height and correct kyphosis. Moreover, blood loss is less. Pain became mild after fixation, which is convenient to early functional exercises after the surgery. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Zhang Y.,Peking Union Medical College | Zhang Y.,First Peoples Hospital of Chengdu | Gu Z.,First Peoples Hospital of Chengdu | Qiu G.,Peking Union Medical College
BioMed Research International | Year: 2014

Objective. Idiopathic scoliosis is the most common pediatric spinal deformity affecting 1% to 3% of the population, and adolescent idiopathic scoliosis (AIS) accounts for approximately 80% of these cases; however, the etiology and pathogenesis of AIS are still uncertain. The current study aims to identify the relationship between calmodulin 1 (CALM1) gene and AIS predisposition, to identify the relationship between the genotypes of the SNPs and the clinical phenotypes of AIS. Methods. 146 AIS patients and 146 healthy controls were enrolled into this case-control study. 12 single nucleotide polymorphisms (SNPs) candidates in CALM1 gene were selected to determine the relationship between CALM1 gene and AIS predisposition. Case-only study was performed to determine the effects of these variants on the severity of the condition. Results. Three SNPs from 12 candidates were found to be associated with AIS predisposition. The ORs were observed as 0.549 (95% CI 0.3519-0.8579, P = 0.0079), 0.549 (95% CI 0.3519-0.8579, P = 0.0079), and 1.6139 (95% CI 1.0576-2.4634, P = 0.0257) for rs2300496, rs2300500, and rs3231718, respectively. There was no statistical difference between main curve, severity, and genotype distributions of all of 12 SNPs. Conclusion. Genetic variants of CALM1 gene are associated with AIS susceptibility. © 2014 Yu Zhang et al.


Zhang Y.,Peking Union Medical Hospital | Zhang Y.,First Peoples Hospital of Chengdu | Gu Z.,First Peoples Hospital of Chengdu | Qiu G.,Peking Union Medical Hospital | Song Y.,University of Sichuan
Journal of Craniofacial Surgery | Year: 2013

Spinal cord injury (SCI) is one of the most devastating injuries for patients. Glial cell line-derived neurotrophic factor (GDNF) is an important neurotrophic factor for the regeneration of the spinal neuraxial bundle, but GDNF would degrade rapidly if the protein was injected into the site of injury; thus, it cannot exert its fullest effects. Therefore, we introduced a delivery system of GDNF, poly(lactide-co-glycolic acid) (PLGA) delayed-release microspheres, in the current study and observed the effect of PLGA-GDNF and the combination of PLGA-GDNF and another 2 agents PLGA-chondroitinase ABC (ChABC) and PLGA-Nogo A antibody in the treatment of SCI rats. Our results showed that PLGA-GDNF and the combination of chABC, GDNF, and Nogo A antibody microspheres could elevate the locomotor scores of SCI rats. The effect of PLGA-GDNF was much better than that of GDNF. The cortical somatosensory evoked potential was also improved by PLGA-GDNF and the combination of chABC, GDNF, and Nogo A antibody microspheres. Our results suggest that PLGA delayed-release microsphere may be a useful and effective tool in delivering protein agents into the injury sites of patients with SCI. This novel combination therapy may provide a new idea in promoting the functional recovery of the damaged spinal cord. Copyright © 2013 Mutaz B. Habal, MD.


Zhu Q.,University of Sichuan | Ruan J.,University of Sichuan | Zhang L.,First Peoples Hospital of Chengdu | Jiang W.,University of Sichuan | And 2 more authors.
Archives of Gynecology and Obstetrics | Year: 2012

Purpose It is to compare the thermal damage on myo-metrium tissue caused by five electrosurgical instruments, including monopolar forceps, bipolar forceps, PK scalpel, Ligasure and BiClamp. Methods Normal myometrium in vitro was collected and electric coagulation was conducted with five electrosurgi-cal instruments under corresponding powers. The zones of thermal injury (ZTI) in each coagulation sites were examined histologically, while the width and depth of thermal damage were measured. Results 1. There were significant differences among various groups' widths of ZTI of myometrium (P < 0.05). Ligasure produced the greatest width of ZTI, and it was statistically greater than that of PK scalpel and BiClamp (P < 0.05). While the widths of ZTI caused by monopolar and bipolar electrocoagulation lied between that of Ligasure and PK scalpel, but the differences were of no statistical significance (P > 0.05). 2. The depths of ZTI in different groups were of significant differences (P < 0.05). Both monopolar and bipolar forceps had greater depths of ZTI compared with BiClamp (P <0.05) but not had statistical differences with Ligasure and PK scalpel (P>0.05). Conclusions As for myometrium, the thermal damage is rather small in the horizontal and vertical directions when using BiClamp and PK scalpel. Ligasure places larger range of thermal damage in horizontal direction with little depth in vertical direction, which is rather safe when acting on uterine surface. Electrocoagulation was conducted with monopolar (the power is 55 W) and bipolar forceps (the power is 40 W) continuously for 3 s, whose thermal damage range is fairly safe to corpus uteri wall and fundus uteri. © 2012 Springer-Verlag.


Zou X.-Y.,First Peoples Hospital of Chengdu | Yu Z.-H.,First Peoples Hospital of Chengdu | He Y.-M.,First Peoples Hospital of Chengdu | Yang H.,First Peoples Hospital of Chengdu | Dong X.-L.,First Peoples Hospital of Chengdu
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

OBJECTIVE: To observe effects of acupuncture combined speech therapy for cerebral palsy children with linguistic retardation.CONCLUSION: Acupuncture combined speech therapy showed obvious effects on cerebral palsy children with linguistic retardation.METHODS: Totally 132 cerebral palsy children were randomly assigned to the speech training group (Group A, 44 cases) and the routine acupuncture combined speech training group (Group B, 44 cases), and the acupuncture combined speech training group (Group C, 44 cases). Patients in Group A received one to one training including game therapy, therapy of communication attitudes, and so on. Those in the other two groups were needed at Baihui (GV20), Sishencong (EX-HN1), the first language zone, the second language zone, and the third language zone. Those in Group B were treated with electric needling and then speech training. Those in Group C were treated with language training, while needling with needle maintaining for 40 min. All patients were treated once daily, 5 times per week, 20 times as one course of treatment, 6 courses in total. The efficacy was assessed using S-S phonetic speech developmental retardation examination (CRRC version). The development quotient (DQ) was observed referring to the Gesell intellectual development scale before treatment, after 3 and 6 treatment courses.RESULTS: Compared with Group A (the total effective rate: 51.3%, DQ value: 58.1 +/- 13.3), better effects were obtained in Group B (the total effective rate: 77.5%, DQ value: 60.4 +/- 13.5) and Group C (the total effective rate: 81.0%, DQ value: 64.0 +/- 11.6) (all P < 0.05). There was no statistical difference in the total effective rate or post-treatment DQ value between Group B and Group C (P > 0.05).


PubMed | First Peoples Hospital of Chengdu
Type: Journal Article | Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine | Year: 2013

To observe effects of acupuncture combined speech therapy for cerebral palsy children with linguistic retardation.Totally 132 cerebral palsy children were randomly assigned to the speech training group (Group A, 44 cases) and the routine acupuncture combined speech training group (Group B, 44 cases), and the acupuncture combined speech training group (Group C, 44 cases). Patients in Group A received one to one training including game therapy, therapy of communication attitudes, and so on. Those in the other two groups were needed at Baihui (GV20), Sishencong (EX-HN1), the first language zone, the second language zone, and the third language zone. Those in Group B were treated with electric needling and then speech training. Those in Group C were treated with language training, while needling with needle maintaining for 40 min. All patients were treated once daily, 5 times per week, 20 times as one course of treatment, 6 courses in total. The efficacy was assessed using S-S phonetic speech developmental retardation examination (CRRC version). The development quotient (DQ) was observed referring to the Gesell intellectual development scale before treatment, after 3 and 6 treatment courses.Compared with Group A (the total effective rate: 51.3%, DQ value: 58.1 +/- 13.3), better effects were obtained in Group B (the total effective rate: 77.5%, DQ value: 60.4 +/- 13.5) and Group C (the total effective rate: 81.0%, DQ value: 64.0 +/- 11.6) (all P < 0.05). There was no statistical difference in the total effective rate or post-treatment DQ value between Group B and Group C (P > 0.05).Acupuncture combined speech therapy showed obvious effects on cerebral palsy children with linguistic retardation.

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