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Tai Z.,CAS Lanzhou Institute of Chemical Physics | Yang J.,CAS Lanzhou Institute of Chemical Physics | Qi Y.,First People Hospital of Lianyungang | Yan X.,CAS Lanzhou Institute of Chemical Physics | Xue Q.,CAS Lanzhou Institute of Chemical Physics
RSC Advances | Year: 2013

In this study, an "intelligent" graphene oxide-polyacrylic acid (GO-PAA) nanocomposite hydrogel was synthesized using a simple PAA cross-linking reaction. The incorporation of the GO phase into the PAA hydrogel was verified using Fourier transformation infrared spectroscopy and ultraviolet-vis spectroscopy. The mechanical, swelling and electroresponsive properties of the GO-PAA nanocomposite hydrogel were studied. The results showed that the addition of a small quantity of GO (3 wt%) did not obviously decrease the transmittance of the pristine PAA hydrogel. After adding GO, both the compressive strength and the water absorbing capacity of the GO-PAA nanocomposite hydrogel were enhanced as expected. Furthermore, the GO-PAA hydrogel displayed a much higher electroresponsive rate compared with the PAA hydrogel, especially under stronger electrical fields. The facile and efficient preparation of the GO-PAA composite hydrogel means it will have potential applications as a smart and super absorbent composite. © The Royal Society of Chemistry 2013. Source

Xu T.-P.,Nanjing Medical University | Zhu C.-H.,Jiangsu University | Zhang J.,Nanjing Medical University | Xia R.,Nanjing Medical University | And 5 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Objective: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of microRNA-155 are inconclusive. The aim of the present analysis was therefore to evaluate the role of miR-155 in prognosis for patients with a variety of carcinomas. Methods: Relevant studies were identified by searching PubMed and EMBASE. Data were extracted from studies comparing overall survival (OS), recurrence-free survival (RFS) or cancer-specific survival (CSS) in patients with carcinoma with higher miR-155 expression and those with lower levels. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miR-155 for clinical outcome were calculated. Results: A total of 15 studies were included. The pooled hazard ratio (HR) for OS of higher miR-155 expression in cancerous tissue was 1.89 (95% CI: 1.20-2.99, P =0.006), which could markedly predict poorer survival in general cancer. For RFS/CSS, elevated miR-155 was also associated with poor prognosis of cancer (HR= 1.50, 95% CI: 1.10-2.05, P = 0.01). On subgroup analysis, the pooled HR for OS in non-small cell lung cancer (NSCLC) was 2.09 (95% CI: 0.68-6.41, P > 0.05), but for RFS/CSS was 1.28 (95% CI: 1.05-1.55, P = 0.015), with statistical significance; the pooled HRs for OS and RFS/CSS in digestive system neoplasms were 3.04 (95% CI: 1.48-6.24, P =0.003) and 2.61 (95% CI: 1.98-3.42, P<0.05), respectively. Conclusions: The results indicated that the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas. Source

Wu F.,First People Hospital of Lianyungang | Zhang J.,Nanjing Medical University | Liu Y.,First People Hospital of Lianyungang | Zheng Y.,First People Hospital of Lianyungang | Hu N.,First People Hospital of Lianyungang
Cellular Physiology and Biochemistry | Year: 2013

Aim: To investigate whether the hypoxia-inducible factor-1α (HIF-1α) genetic variants and protein expression affect the chemotherapy response and the clinical outcome of patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 741 patients with histologically confirmed advanced NSCLC were recruited. Two polymorphisms of HIF-1α gene, namely, the C1772T (P582S) and G1790A (A588T) polymorphisms were determined. The HIF-1α protein expression was determined in 162 different biopsy samples by immunohistochemistry. Results: All patients received platinum-based chemotherapy, 311 were chemotherapy responders and 430 were non-responders. The 1772 CC genotype carriers had a higher chance to be chemotherapy responders compared with those carrying the TT genotype. Patients with high HIF-1α expressions had a significantly higher chance to be non-responder to chemotherapy than those with low HIF-1α expressions. The patients with 1772CC had markedly longer overall survival (OS) and progression free survival (PFS) than those carrying the 1772CT and 1772TT genotype. The HIF-1α expression level was significantly related to the OS, but not PFS. Conclusion: The results of our study suggest that HIF1α genetic variants and protein expression may be used as marker to screen NSCLC patients who are more likely to be responder to platinum based chemotherapy. © 2013 S. Karger AG, Basel. Source

Wu F.,First People Hospital of Lianyungang | Zhang J.,Nanjing Medical University | Hu N.,First People Hospital of Lianyungang | Wang H.,Nanjing Medical University | And 3 more authors.
Cancer Epidemiology | Year: 2014

Aim: To identify the single-nucleotide polymorphism (SNP) of hENT1 G-706C that is associated with response to gemcitabine-containing chemotherapy, and to determine the prognosis in patients with non-small-cell lung cancer (NSCLC). Methods: Patients with stage III (A. +. B) or IV NSCLC were recruited for this study (. n=. 225). Each subject received gemcitabine-containing chemotherapy. The association between human equilibrative nucleoside transporter 1 (. hENT1) polymorphism G-706C (rs61758845) and therapeutic effect was evaluated. The SNP hENT1 G-706C was genotyped by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) assays. Results: The polymorphic genotype and the allele frequency of hENT1 G-706C was significantly different between chemotherapy responders and non-responders; to be specific, the response rate of patients carrying an hENT1-706 GG allele was higher than that of patients with a GC or CC genotype. Logistic regression analysis showed that having the GC or CC genotypes was associated with a higher risk of being a non-responder compared with having the GG genotype (OR. =. 2.34, 95% CI: 1.14-4.80; P=. 0.02). The overall survival in patients with the GG genotype was significantly longer than in those with GC or CC genotype (19.0 versus 15.1 months, P<. 0.001). The hazard ratio for the (GC. +. CC) genotype was 1.89 (95% CI: 1.23-2.90) compared with GG carriers (. P=. 0.004). Conclusions: The hENT1 genetic polymorphism of hENT1 G-706C was associated with response to the gemcitabine-containing chemotherapy and prognosis of NSCLC. Moreover, assaying this SNP in blood cells may represent a valuable biomarker for individualized treatment for NSCLC patients. © 2014 Elsevier Ltd. Source

Xue P.,First People Hospital of Lianyungang | Tu C.,First People Hospital of Lianyungang | Wang K.,First People Hospital of Lianyungang | Wang X.,First People Hospital of Lianyungang | Fang Y.,First People Hospital of Lianyungang
International Urology and Nephrology | Year: 2013

Purpose: The aim of this study was to assess the analgesic efficacy of intracutaneous sterile water injection compared with oral paracetamol in pregnant women with acute renal colic caused by urolithiasis. Methods: The study included 45 patients randomized into two different groups: Group A (n = 24) received paracetamol (1,000 mg, oral), while group B (n = 21) received sterile water injections. The severity of pain was assessed by a visual analogue scale (VAS) system at baseline and at 15, 30 min, and 1 h after administering the treatments. Subjects with inadequate pain relief at 1 h received rescue analgesia. Results: The VAS values prior to the start of therapy and 15, 30 min, and 1 h after therapy were 85.42 ± 10.62, 69.17 ± 8.3, 45.42 ± 12.5, and 32.08 ± 14.44 for the paracetamol group, while for the sterile water injection group, the VAS values were 90.48 ± 11.17, 30.95 ± 16.7, 14.76 ± 11.23, and 10.48 ± 8.65, respectively. There was no statistically significant difference between the starting VAS values of the two groups, but the VAS values 15, 30 min, and 1 h after paracetamol administration were statistically less in the group that received sterile water injections. Rescue analgesics at 1 h were required by eight subjects (33 %) receiving paracetamol and one subject (5 %) receiving sterile water injection. Conclusions: Intracutaneous injection of sterile water is an efficacious treatment for renal colic caused by urolithiasis in pregnant women. It was significantly superior to oral administration of paracetamol. © 2013 Springer Science+Business Media Dordrecht. Source

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