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Li M.,Xian Jiaotong University | Ji Y.,First Hospital of xiAn | Dong Y.,Xian Jiaotong University | Zhou Y.,Xian Jiaotong University | And 2 more authors.
Inflammation | Year: 2013

Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease characterized by endothelial cell dysfunction, which results in plasma exosmosis, hyperpermeability, and sometimes hemorrhages. As one of the vascular permeability cytokines, vascular endothelial growth factor (VEGF) might mediate the hyperpermeability caused by HFRS. In the present study, the levels of serum VEGF were measured by competitive inhibition ELISA. We found variable but persistently elevated levels of VEGF throughout the various stages and types of HFRS disease, which suggested that the levels of VEGF were closely correlated to the progression of HFRS. Moreover, elevated levels of VEGF have correlation with the severity and degree of kidney damage. Therefore, to study the relationship between levels of VEGF and disease severity of patients with HFRS is helpful to clarify the pathogenesis of HFRS. © 2013 Springer Science+Business Media New York.

Chai J.,PLA Fourth Military Medical University | Wang X.,First Hospital of xiAn | Mei Q.,PLA Fourth Military Medical University | Yue Z.,PLA Fourth Military Medical University
Phytochemistry Letters | Year: 2014

Two new compounds (1) and (2) were obtained from the roots and rhizomes of Trillium tschonoskii, and their structures were identified as (2,3-S-trans,10R,6E)-7,11-dimethyl-3-methylene-1,6-dodecadien-10,11-diol 10-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (1) and (23S,24S,25S)-spirost-5-en-1β,3β,21,23,24-pentaol-1-O-β-d-xylopyranosyl-(1→3)-[O-α-l-rhamnopyranosyl-(1→2)]-O-α-l-arabinopyranoside (2) on the basis of physico-chemical properties and spectral analysis. In addition, cytotoxic activity toward HepG2 cell line was tested by the MTT method, and compound 2 showed strong cytotoxicity to the HepG2 cell (IC500.499 μmol L-1). © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Song Y.-M.,TCM Hospital of Xian | Lu P.-L.,First Hospital of xiAn
International Journal of Ophthalmology | Year: 2010

• AIM: To investigate the necessity of classification of the branch retinal vein occlusion (BRVO) based on features of fundus fluorescein angiography (FFA). • METHODS: A toal of 1450 cases with BRVO was studied ,56 cases 56 eyes with retinal vein occlusion point was at the intersection which focused on the inferior retina vein according to FFA images, We classified these affected eye as a special type of BRVO. The morphological characteristics of non-perfusion areas, neovascularization and the size of hemorrhage were observed and analyzed. • RESULTS: The data showed that 56 eyes accounting for 3.9% of the total number of eyes, in which retinal arteriovenous cross and intersection at two level in retinal vein 29 eyes, at three level in retinal intersection 18 eyes, above three level in retinal intersection 9 eyes. 42 cases of FFA showed that there was a small zone of low fluorescence without perfusion, 16 cases had neovascularization and hyperfluorescence, and no vitreous hemorrhage, proliferative retinopathy and traction retinal detachment and other complications. • CONCLUSION: The affected occlusion point which focused on the inferior retina intersection determined by FFA is not similar to that of patient with BRVO. It has the characteristics of slight retinal damage, small bleeding areas, and small area with nonperfusion and low neovascularazitions on FFA. The further classification may be helpful for the clinical diagnosis and therapty of BRVO.

Li Z.-H.,First Hospital of xiAn | Zhang H.,Central Hospital of Shangluo
International Journal of Ophthalmology | Year: 2010

• AIM: To investigate the effect and clinical significance of psychological care for primary glaucoma. • METHODS: A randomized, parallel control study was applied. 275 consecutive patients with primary glaucoma from January 2004 to December 2008 were randomly divided into experimental group, 137 cases with specialist psychological care and control group, 138 cases with routine treatment. After discharge, through the establishment of archives, family follow-up, hold classes and other measures, mental care was performed and the intraocular pressure(IOP), complications, visual prognosis and the quality of life were evaluated. • RESULTS: The postoperative IOP returned to normal accounted for 83.9% (115/137) in experiment group and 73.9% (102/138) in control group (χ2 = 4.15, P < 0.05), there was significant difference in both groups. Operative complication rate (28/109, 25.7%) in experimental group was significantly lower than that in control group (43/95, 45.3%) (χ2 = 4.126, P < 0.05). The quality of life in experimental group was significantly better than that in control group 3 months after surgery (χ2 > 3.84, P < 0.05). • CONCLUSION: The psychological care can promote the recovery of normal IOP and visual function, reduce the incidence of complications in patients with primary glaucoma, especially it is beneficial to cultivate the confidence and improve the quality of life of patients, and has important clinical value.

Ji Y.,First Hospital of xiAn | Zhao Z.,First Hospital of xiAn | Cai T.,Xian Medical University | Yang P.,First Hospital of xiAn | Cheng M.,First Hospital of xiAn
Molecular Medicine Reports | Year: 2014

Clinically, diabetes mellitus is closely associated with and induces certain cardiovascular diseases. The aim of this study was to investigate endoplasmic reticulum (ER) stress-associated apoptosis of diabetic cardiomyopathy (DCM), and explore the protective mechanism of liraglutide. The DCM model was established with a high-fat diet and streptozotocin (STZ). Cardiac function was detected by echocardiogram examination and hematoxylin-eosin staining. ER stress unfolded protein response (UPR) hallmarks [inositol-requiring enzyme-α (IRE-α), p-Perk and ATF6] and transcription factors were detected with western blotting. Apoptosis inducers CHOP, c-Jun amino terminal kinase (JNK) and casapse-12 were also examined with western blotting. The results indicated that liraglutide is capable of improving cardiac function in DCM rats (P<0.05). IRE-α expression was significantly increased in the DCM group compared with the control group (P<0.05), and liraglutide is capable of decreasing IRE-α expression. X-box transcription factor-1 (XBP-1) was significantly spliced in the model group, and downregulated in the liraglutide-treated group. CHOP protein was upregulated in the DCM group, but inactivated by liraglutide treatment. In conclusion, liraglutide is capable of protecting DCM and blocking CHOP-mediated ER stress by inhibiting the IRE-α UPR pathway.

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