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Mei J.H.,First Hospital of Wuhan City
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2010

To study the influence of neuro-psychological factors on the effect of acupuncture in the treatment of Bell's palsy and the overall prognosis in patients. Fifty patients with Bell's palsy were randomized into the treatment group and the control group, and they were treated with manipulated and non-manipulated acupuncture, respectively. Scorings by subjective perceptive scale of acupuncture, Cartel personality test, and Hamilton Anxiety Scale were performed and the curative effect was assessed according House-Brackmann grading standards. The total effective rate of acupuncture was 78.0% (39/50), and that of manipulated acupuncture was better than that of non-manipulated acupuncture [89.2% (25/28) vs. 63.6% (14/22), P < 0.01]. Visual analogue scoring for perception of "Deqi", evaluated either by patients or by doctors, showed that the scores was higher in the treatment group than in the control group (P < 0.01). Cartel personality test (16PF) found that patients with personality factors of sociability, intellectuality, excitability, braveness, and independence were capable of getting "Deqi" more easily, there existed a significant correlation between personality factors and curative effect. By Hamilton Anxiety Scale scoring, 92.0% (46/50) of the patients were found being in an anxiety state, and the efficacy of treatment was negatively correlated with the degree of anxiety (r = -0.9491, P < 0.05). Neuro-psychological factors put great influence on the efficacy of treatment for Bell's palsy, multiple measures, such as drug-therapy, acupuncture, psychological intervention, rehabilitation therapy, etc., should be taken in combination for improving patients' prognosis.

Wang P.,Huazhong University of Science and Technology | Xu C.,Huazhong University of Science and Technology | Wang C.,Huazhong University of Science and Technology | Wu Y.,First Hospital of Wuhan City | And 13 more authors.
PLoS ONE | Year: 2015

Heart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar role in humans is unknown. We studied a functional variant, rs9943582 (-154G/A), at the 5′-untranslated region, that was associated with decreased expression of the APJ receptor gene (APLNR) in a population consisting of 1,751 CAD cases and 1,022 controls. Variant rs9943582 was not associated with CAD, but among CAD patients, it showed significant association with left ventricular systolic dysfunction (431 CAD patients with left ventricular systolic dysfunction (LV ejection fraction or LVEF<40%) versus 1,046 CAD patients without LV systolic dysfunction (LVEF>50%) (P-adj = 6.71×10 6.71×10-5-,OR=1.43, 95% CI, 1.20-1.70). Moreover, rs9943582 also showed significant association with quantitative echocardiographic parameters, including left ventricular end-diastolic diameter (effect size: increased 1.67±0.43 mm per risk allele A, P = 1.15×10-4), left atrial size (effect size: increased 2.12±0.61 mm per risk allele A, P = 9.56×10-4) and LVEF (effect size: decreased 2.59±0.32 percent per risk allele A, P = 7.50×10-15). Our findings demonstrate that allele A of rs9943582 was significantly associated with left ventricular systolic dysfunction, left ventricular end-diastolic diameter, the left atrial diameter and LVEF in the CAD population, which suggests an important role of the apelin/APJ system in the pathology of heart failure associated with ischemic heart disease. © 2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Kang W.-M.,Peking Union Medical College | Meng Q.-B.,First Hospital of Wuhan City | Yu J.-C.,Peking Union Medical College | Ma Z.-Q.,Peking Union Medical College | Li Z.-T.,Peking Union Medical College
World Journal of Gastroenterology | Year: 2015

AIM: To characterize patterns of gastric cancer recurrence and patient survival and to identify predictors of early recurrence after surgery. METHODS: Clinicopathological data for 417 consecutive patients who underwent curative resection for gastric cancer were retrospectively analyzed. Tumor and node status was reclassified according to the 7th edition of the American Joint Committee on Cancer tumor-node-metastasis classification for carcinoma of the stomach. Survival data came from both the patients' follow-up records and telephone followups. Recurrent gastric cancer was diagnosed based on clinical imaging, gastroscopy with biopsy, and/or cytological examination of ascites, or intraoperative findings in patients who underwent reoperation. Predictors of early recurrence were compared in patients with pT1 and pT2-4a stage tumors. Pearson's χ2 test and Fisher's exact test were used to compare differences between categorical variables. Survival curves were constructed using the Kaplan-Meier method and compared via the log-rank test. Variables identified as potentially important for early recurrence using univariate analysis were determined by multivariate logistic regression analysis. RESULTS: Of 417 gastric cancer patients, 80 (19.2%) were diagnosed with early gastric cancer and the remaining 337 (80.8%) were diagnosed with locally advanced gastric cancer. After a median follow-up period of 56 mo, 194 patients (46.5%) experienced recurrence. The mean time from curative surgery to recurrence in these 194 patients was 24 ± 18 mo (range, 1-84 mo). Additionally, of these 194 patients, 129 (66.5%) experienced recurrence within 2 years after surgery. There was no significant difference in recurrence patterns between early and late recurrence (P < 0.05 each). For pT1 stage gastric cancer, tumor size (P = 0.011) and pN stage (P = 0.048) were associated with early recurrence of gastric tumors. Patient age, pT stage, pN stage, Lauren histotype, lymphovascular invasion, intraoperative chemotherapy, and postoperative chemotherapy were independent predictors of early recurrence in patients with pT2-4a stage gastric cancer (P < 0.05 each). CONCLUSION: Age, pT stage, pN stage, Lauren histotype, lymphovascular invasion, intraoperative chemotherapy, and postoperative chemotherapy are independent factors influencing early recurrence of pT2-4a stage gastric cancer. © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.

Xiong X.,Huazhong University of Science and Technology | Xu C.,Huazhong University of Science and Technology | Zhang Y.,Huazhong University of Science and Technology | Li X.,Huazhong University of Science and Technology | And 25 more authors.
Human Genetics | Year: 2014

A single nucleotide polymorphism (SNP) rs1122608 on chromosome 19p13.2 and in the BRG1/SMARCA4 gene was previously associated with coronary artery disease (CAD). CAD and ischemic stroke are both associated with atherosclerosis. Thus, we tested the hypothesis that rs1122608 is associated with ischemic stroke. Further studies were used to identify the most likely mechanism by which rs1122608 regulates atherosclerosis. For case-control association studies, two independent Chinese Han GeneID cohorts were used, including a Central cohort with 1,075 cases and 2,685 controls and the Northern cohort with 1,208 cases and 824 controls. eQTL and real-time RT-PCR analyses were used to identify the potential candidate gene(s) affected by rs1122608. The minor allele T of SNP rs1122608 showed significant association with a decreased risk of ischemic stroke in the Central GeneID cohort (adjusted P adj = 2.1 × 10-4, OR 0.61). The association was replicated in an independent Northern GeneID cohort (P adj = 6.00 × 10-3, OR 0.69). The association became more significant in the combined population (P adj = 7.86 × 10-5, OR 0.73). Allele T of SNP rs1122608 also showed significant association with a decreased total cholesterol level (P adj = 0.013). Allele T of rs1122608 was associated with an increased expression level of SFRS3 encoding an mRNA splicing regulator, but not with the expression of BRG1/SMARCA4 or LDLR (located 36 kb from rs1122608). Increased expression of SFSR3 may decrease IL-1β expression and secretion, resulting in reduced risk of atherosclerosis and stroke. This is the first study that demonstrates that rs1122608 confers protection against ischemic stroke and implicates splicing factor SFSR3 in the disease process. © 2013 Springer-Verlag Berlin Heidelberg.

Zhou W.,First Hospital of Wuhan City | Yang Y.,Hubei Zhongshan Hospital | Xia Z.,Huazhong University of Science and Technology | Yang X.,Huazhong University of Science and Technology | And 4 more authors.
Medical Journal of Wuhan University | Year: 2010

Objective: To explore the protective effects and mechanisms of recombinant human erythropoietin(rHuEPO) on renal tubular epithelial cell apoptosis induced by ischemia-reperfusion injury. Methods: The model of ischemia-reperfusion (I/R) injury was established through ischemia for one hour and reperfusion for two hours in cultured renal tubular epithelial (HK-2) cells. HK2 cells were cultured and then divided into five groups as following: (1) control group, (2) I/R group: receiving antimycin A 10 μmol/L and A23187 1 μmol/L, (3) pre-dosage group: I/R + rHuEPO 30 min before ischemia, (4) instant-dosage group: I/R+ rHuEPO 5 min before reperfusion, and (5) delayed-dosage group: I/R+ rHuEPO 30 min following reperfusion. The apoptotic ratio of HK-2 was monitored by FCM. The expression of Akt, GSK-3β and caspase-3 mRNA were assessed by RT-PCR and activities of Akt, GSK-3β and caspase-3 were assessed by Western blot analyses. Results: (1) Compared with control group, the apoptosis ratio of HK-2 increased, expression of phospho-Akt and phospho- GSK-3β markedly decreased and activities of Caspase-3 increased in I/R group (P<0.05). (2) Compared with I/R group, the administration of rHuEPO before ischemia or just after ischemia significantly reduced the extent of apoptotic cells, and was associated with maintenance of improved Akt (Ser473), GSK-3β (Ser9) levels and decreased Caspase-3 activity (P<0.05). Conclusion; The early administration of rHuEPO at ischemia could protect HK-2 from apoptosis induced by ischemia-reperfusion injury through Akt /GSK-3β/ caspase-3 signaling pathway.

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