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Zhang W.,First Hospital of Putian City | Huang Z.,First Hospital of Putian City | Yan J.,Sun Yat Sen University
Journal of Craniofacial Surgery | Year: 2013

BACKGROUND: The study aims to report a rare case of traumatic lysis of inferior rectus muscle after a traffic accident. METHODS: This is a case report wherein the clinical features, computed tomographic findings, and surgical treatment were presented. RESULTS: A 42-year-old woman complained of double vision and upward deviation of the left eye for 13 months after being involved in a traffic accident. The alternate prism and cover test both at distance and near testing showed an exotropia of 18 prism diopters (PD) and hypertropia of 50 PD of the left eye. The left eye had complete restriction of downward movement, and the forced duction test was negative. Computed tomography disclosed that the middle portion of the left inferior rectus muscle was absent. Diagnosis was traumatic lysis of left inferior rectus muscle. The deviation of the left eye was corrected by left superior rectus muscle recession and partial transposition of the medial and lateral rectus muscles. Six months after surgery, no deviation at the primary position both at distance and near testing was present; however, the left eye remained at a -3 restriction of downward movement. CONCLUSIONS: Paralysis of the inferior rectus muscle may have resulted from the traumatic lysis, a rare clinical feature that can be confirmed by computed tomography. Copyright © 2013 Mutaz B. Habal, MD. Source


Zeng Y.,North Zhongshan Road | Zeng Y.,Fujian Medical University | Hong M.,Traditional Chinese Medicine Hospital of Zhangzhou City | Zhang H.,Fujian Medical University | And 6 more authors.
Respirology | Year: 2010

Transbronchoscopic balloon detection and selective bronchial occlusion were applied in the management of 40 patients with intractable pneumothorax. An autologous blood clot was used as a bronchial sealant. The efficacy of the procedure, effect on oxygenation and radiographic changes in occluded areas of the lung were evaluated. Background and objective: The aim of this study was to evaluate the efficacy, complications and safety of the application of transbronchoscopic balloon detection (TBD) and selective bronchial occlusion (SBO) to intractable pneumothorax. Methods: Forty patients with pneumothorax, who had experienced more than 7 days of chest tube drainage without closure of the pleural fistula, underwent TBD and SBO. In 10 patients, oxygenation and pulse rates were recorded. A thoracic CT scan was performed 10 days after SBO. Results: The bronchi leading to the pleural fistula were located by TBD in 34 of 40 patients (85%). The air leakages ceased after the first occlusion in 30 patients, and five of these 30 patients underwent a second occlusion due to recurrence of pneumothorax 72 h after the first occlusion. In three of these patients, air leakages ceased after the second occlusion, while the remaining two patients underwent thoracoscopy. In total, 28 of 40 patients (70%) were cured using SBO. During TBD/SBO, the lowest SaO2 was 89.0 ± 2.8%, the mean SaO2 was 93.4 ± 2. 6% and the percentage of time during the procedure that SaO2 was <90% was 10.7 ± 17.5%. Ten days after SBO, thoracic CT scans were performed on 10 patients and no obstructive atelectasis was detected in any patient. Conclusions: These results indicate that TBD and SBO are safe and effective procedures for treating patients with intractable pneumothorax. © 2009 Asian Pacific Society of Respirology. Source


Xu X.,First Hospital of Putian City | Lin J.,First Hospital of Putian City | Zheng M.,First Hospital of Putian City | Huang C.,First Hospital of Putian City | And 2 more authors.
Cancer Research and Clinic | Year: 2016

Objective: To explore the relations among the promoter methylation of tissue inhibitor of metalloproteinase-3 (TIMP-3) gene and its protein expression, and the clinicopathological features in the gastric cardia carcinoma. Methods: The tumor tissues and the adjacent normal mucosal tissues were collected from 65 patients with cardia carcinoma. The promoter methylation levels and the protein expression of TIMP-3 gene were detected by methylation-specific PCR (MSP) and immunohistochemistry respectively. Results: The TIMP-3 methylation rates was 78.5 % (51/65) in the tumor tissues and 13.8 % (9/65) in the incisai edge of normal tissues, the methylation rates of TIMP-3 had positive correlation with the size of tumor, invasion depth, lymphatic metastasis and the stage of tumor. The protein expression of TIMP-3 was 26.2 % (17/65) in the tumor tissues and 95.4 % (62/65) in the incisai edge of normal tissues (P = 0.016), the protein expression of TIMP-3 was negatively correlated with the size of tumor, invasion depth, lymphatic metastasis and the stage of tumor. Conclusion: The methylation of promoter region in CpG islands is a main mechanism of reduced and loss expression of TIMP-3 gene, which may play an important role in the invasion and metastasis of cardia carcinoma. Source


Chen G.-X.,First Hospital of Putian City | Wang G.-R.,First Hospital of Putian City | Lin Z.-J.,First Hospital of Putian City | Li G.-S.,First Hospital of Putian City | And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Osteoclast as a terminal cell is difficult to obtain, and the shortage of mature osteoclast strains limits its application. Previous studies have shown that stromal cell culture or co-culture is commonly used to obtain the osteoclasts, and the receptor activator of nuclear factor κB ligand and macrophage colony-stimulating factor can be used in combination in order to obtain the mature osteoclasts. Objective: To observe the biological characteristics of mouse monocyte macrophage RAW264.7, and to analyze the feasibility of receptor activator of nuclear factor κB ligand-mediated differentiation of monocyte macrophage RAW264.7 into osteoclasts. Methods: The RAW264.7 cells were cultured, and then the RAW264.7 cells were induced with receptor activator of nuclear factor κB ligand for 7 days to observe the tartrate-resistant acid phosphatase staining results. The positive tartrate-resistant acid phosphatase staining and nucleus ≥ 3 were considered as the osteoclasts. Phalloidin staining was used to observe fibrous actin ring, and toluidine blue staining was used to observe the resorption pits on the surface of bovine bone slice. Results and Conclusion: RAW264.7 cells could be induced into tartrate-resistant acid phosphatase-positive multinuclear cells with receptor activator of nuclear factor κB ligand, and formed fibrous actin rings; round or ellipse bone resorption pits were found in bone slice surface by microscope. RAW264.7 cells were considered as a good preosteoclast model that used for research of osteoclast differentiation. Receptor activator of nuclear factor κB ligand can induce the differentiation and maturation of RAW264.7 cells, reduce the application of macrophage colony-stimulating factor and make the training system simpler and easier to operate, and the induced cells have the high purity suitable for biological and biochemical studies of osteoclasts. Source

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