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Putian, China

Zhao Z.-Q.,First Hospital of Putian | Yang S.,Fuzhou University | Lu H.-S.,Fuzhou University
Molecular Medicine Reports

The aim of the present study was to investigate the expression of midkine (MK) and vascular endothelial growth factor (VEGF) in gastric cancer and its relationship with gastric cancer prognosis and survival rate. We recruited 107 patients with complete clinical data and available tissue samples [gastric cancer tissue (n=107); adjacent normal gastric mucosa (n=31)]. MK and VEGF expression in these tissues were assayed by immunohistochemistry. The association of MK or VEGF expression with various prognostic factors in gastric cancer and the 5-year survival of gastric cancer patients were analyzed. MK and VEGF immunoreactivity were detected in 69.2% (74 out of 107 cases) and 66.4% (71 out of 107 cases) of gastric cancer tissues, but not in normal gastric tissues (P=0.00). MK and VEGF expression was correlated with tumor size, depth of invasion, lymph node metastasis and pathological stage (P<0.01), but not with age and gender (P>0.05). MK expression was positively correlated with VEGF expression (r=0.681, P<0.01). In addition, MK or VEGF expression was negatively correlated with the 5-year survival rate (P<0.01). The 5-year survival rate was significantly higher in patients with MK- or VEGF-immunonegative tumors than in patients with immunopositive ones (P<0.01). Co-expression of MK and VEGF was an independent predictor of gastric cancer prognosis. Expression of MK and VEGF is increased in gastric cancer and increased expression is closely correlated with poor prognosis and survival. Source

Li Z.-X.,First Hospital of Putian | Xu Y.-C.,First Hospital of Putian | Lin W.-L.,First Hospital of Putian | Chen J.,First Hospital of Putian | Wu H.-Y.,First Hospital of Putian
Journal of B.U.ON.

Purpose: To explore the feasibility and short-term effect of laparoscopy-assisted D2 radical gastrectomy for advanced gastric cancer. Methods: A total of 239 patients with advanced gastric cancer underwent D2 radical gastrectomy between March 2009 and June 2011, from which 106 patients underwent laparoscopic surgery (laparoscopy group) and 133 patients underwent open surgery (open surgery group). The intraoperative and postoperative condition, number of lymph node removed, complications and mortality rates between the two groups were compared. Results: The operation time (268±51 min) and the number of lymph node removed (29.1±6.1) in the laparoscopy group were comparable with the operation time (268±49 min) and the number of lymph node removed (30.2±7.0) in the open surgery group, while there were significant differences in the intraoperative bleeding (134±66 vs 289±139 ml), intraoperative blood infusion cases (5 vs 19), time to first postoperative flatus (3.4±0.9 vs 5.0±1.4 days), time to first taking liquid food (7.3±1.3 vs 8.1±1.4 days) and postoperative hospital stay (12.8±2.6 vs 14.5±3.1 days) between the two groups (p<0.05). These results favored the laparoscopy group. The incidence of postoperative complications in the laparoscopy and open surgery group were 14.1 and 24.8, respectively (p<0.05). Compared with the open surgery, the laparoscopic surgery significantly reduced the incidence of pulmonary infection (p<0.05). There was no significant difference in the postoperative short-term survival rate between the two groups (p>0.05). Conclusion: Laparoscopy-assisted D2 gastrectomy for advanced gastric cancer is advantageous in terms of safety and feasibility, rapid postoperative recovery and few complications. Both groups gave comparable results in terms of lymph node dissection and short-term survival. Source

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