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Hou X.,First Hospital of Beijing University | Ding H.,Tsinghua University | Teng Y.,Tsinghua University | Zhou C.,First Hospital of Beijing University | Zhang D.,Beijing Normal University
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS | Year: 2011

To study the changes of cerebral oxygenation and hemodynamics in normal neonates at 2-5 min post-birth and understand the effects of pregnancy-induced hypertension (PIH) upon cerebral oxygenation and hemodynamics in newborn neonates. The near infrared spectroscopy (NIRS) was employed to measure the absolute quantity of brain tissue oxygen saturation (rSO2) in newborn neonates and the changes of concentrations of deoxyhemoglobin (Hb) and oxygenation hemoglobin (HbO2) with time relative to initial values to further obtain the changes of total hemoglobin (tHb) and cerebral perfusion (denoted by HbD). In normal neonates at 2-5 min post-birth, rSO2 increased while tHb remained relatively stable and HbD increased. In neonates born of PIH mothers at 3-5 min post-birth, the changes of tHb were markedly higher than those in the normal infants, p<0.05; at 2-5 min post-birth, the changes were markedly lower than the normal term infants. We concluded that NIRS can detect the changes of cerebral oxygenation and blood flow in a non-invasive and effective way. © 2011 IEEE.


Han Y.,Shenyang Northern Hospital | Zhu G.,WuHan Asia Heart Hospital | Han L.,CangZhou Central Hospital | Hou F.,Changchun Central Hospital | And 19 more authors.
Journal of the American College of Cardiology | Year: 2014

Objectives This study sought to evaluate the safety and efficacy of rosuvastatin in preventing contrast-induced acute kidney injury (CI-AKI) in patients with diabetes mellitus (DM) and chronic kidney disease (CKD). Background CI-AKI is an important complication after contrast medium injection. While small studies have shown positive results with statin therapy, the role of statin therapy in prevention of CI-AKI remains unknown. Methods We randomized 2,998 patients with type 2 DM and concomitant CKD who were undergoing coronary/peripheral arterial angiography with or without percutaneous intervention to receive rosuvastatin, 10 mg/day (n = 1,498), for 5 days (2 days before, and 3 days after procedure) or standard-of-care (n = 1,500). Patients' renal function was assessed at baseline, 48 h, and 72 h after exposure to contrast medium. The primary endpoint of the study was the development of CI-AKI, which was defined as an increase in serum creatinine concentration ≥0.5 mg/dl (44.2 μmol/l) or 0.25% above baseline at 72 h after exposure to contrast medium. Results Patients randomized to the rosuvastatin group had a significantly lower incidence of CI-AKI than controls (2.3% vs. 3.9%, respectively; p = 0.01). During 30 days' follow-up, the rate of worsening heart failure was significantly lower in the patients treated with rosuvastatin than that in the control group (2.6% vs. 4.3%, respectively; p = 0.02). Conclusions Rosuvastatin significantly reduced the risk of CI-AKI in patients with DM and CKD undergoing arterial contrast medium injection. (Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes [TRACK-D]; NCT00786136).


PubMed | Jinan Military General Hospital, Shenyang Northern Hospital, WuHan Asia Heart Hospital, General Hospital of Armed Police Forces and 14 more.
Type: Comparative Study | Journal: Journal of the American College of Cardiology | Year: 2014

This study sought to evaluate the safety and efficacy of rosuvastatin in preventing contrast-induced acute kidney injury (CI-AKI) in patients with diabetes mellitus (DM) and chronic kidney disease (CKD).CI-AKI is an important complication after contrast medium injection. While small studies have shown positive results with statin therapy, the role of statin therapy in prevention of CI-AKI remains unknown.We randomized 2,998 patients with type 2 DM and concomitant CKD who were undergoing coronary/peripheral arterial angiography with or without percutaneous intervention to receive rosuvastatin, 10 mg/day (n = 1,498), for 5 days (2 days before, and 3 days after procedure) or standard-of-care (n = 1,500). Patients renal function was assessed at baseline, 48 h, and 72 h after exposure to contrast medium. The primary endpoint of the study was the development of CI-AKI, which was defined as an increase in serum creatinine concentration 0.5 mg/dl (44.2 mol/l) or 0.25% above baseline at 72 h after exposure to contrast medium.Patients randomized to the rosuvastatin group had a significantly lower incidence of CI-AKI than controls (2.3% vs. 3.9%, respectively; p = 0.01). During 30 days follow-up, the rate of worsening heart failure was significantly lower in the patients treated with rosuvastatin than that in the control group (2.6% vs. 4.3%, respectively; p = 0.02).Rosuvastatin significantly reduced the risk of CI-AKI in patients with DM and CKD undergoing arterial contrast medium injection. (Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes [TRACK-D]; NCT00786136).


Zhou W.-H.,Fudan University | Cheng G.-Q.,Fudan University | Shao X.-M.,Fudan University | Liu X.-Z.,Guangxi Maternity and Infant Health Hospital | And 7 more authors.
Journal of Pediatrics | Year: 2010

Objective: To investigate the efficacy and safety of selective head cooling with mild systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. Study design: Infants with HIE were randomly assigned to the selective head cooling or control group. Selective head cooling was initiated within 6 hours after birth to a nasopharyngeal temperature of 34° ± 0.2°C and rectal temperature of 34.5° to 35.0°C for 72 hours. Rectal temperature was maintained at 36.0° to 37.5°C in the control group. Neurodevelopmental outcome was assessed at 18 months of age. The primary outcome was a combined end point of death and severe disability. Results: One hundred ninety-four infants were available for analysis (100 and 94 infants in the selective head cooling and control group, respectively). For the selective head cooling and control groups, respectively, the combined outcome of death and severe disability was 31% and 49% (OR: 0.47; 95% CI: 0.26-0.84; P = .01), the mortality rate was 20% and 29% (OR:0.62; 95% CI: 0.32-1.20; P = .16), and the severe disability rate was 14% (11/80) and 28% (19/67) (OR: 0.40; 95% CI: 0.17-0.92; P = .01). Conclusions: Selective head cooling combined with mild systemic hypothermia for 72 hours may significantly decrease the combined outcome of severe disability and death, as well as severe disability. © 2010 Mosby Inc. All rights reserved.


Hou X.,First Hospital of Beijing University
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | Year: 2011

To study the changes of cerebral oxygenation and hemodynamics in normal neonates at 2-5 min post-birth and understand the effects of pregnancy-induced hypertension (PIH) upon cerebral oxygenation and hemodynamics in newborn neonates. The near infrared spectroscopy (NIRS) was employed to measure the absolute quantity of brain tissue oxygen saturation (rSO2) in newborn neonates and the changes of concentrations of deoxyhemoglobin (Hb) and oxygenation hemoglobin (HbO2) with time relative to initial values to further obtain the changes of total hemoglobin (tHb) and cerebral perfusion (denoted by HbD). In normal neonates at 2-5 min post-birth, rSO2 increased while tHb remained relatively stable and HbD increased. In neonates born of PIH mothers at 3-5 min post-birth, the changes of tHb were markedly higher than those in the normal infants, p<0.05; at 2-5 min post-birth, the changes were markedly lower than the normal term infants. We concluded that NIRS can detect the changes of cerebral oxygenation and blood flow in a non-invasive and effective way.


Xue Q.,First Hospital of Beijing University | Zhou Y.F.,First Hospital of Beijing University | Zhu S.N.,First Hospital of Beijing University | Bulun S.E.,Northwestern University
Reproductive Sciences | Year: 2011

Endometriosis is an estrogen-dependent disease. Steroidogenic factor 1 (SF-1), a transcription factor, is essential for the activation of multiple steroidogenic genes for estrogen biosynthesis in endometriosis-derived stromal cells. Objective: Unravel the mechanism for differential SF-1 expression in endometrial and endometriotic stromal cells. DESIGN: We identified a novel CpG island in the SF-1 gene, which spans from exon II to intron III. We evaluated the methylation status of this CpG island. PATIENTS: Eutopic endometrium from disease-free participants (n = 8) and the walls of cystic endometriosis lesions of the ovaries (n = 8). None of the patients had received any preoperative hormonal therapy. Stromal cells were isolated from these 2 types of tissues. Results: SF-1 messenger RNA (mRNA) levels in endometriotic stromal cells were significantly higher than those in endometrial stromal cells. Bisulfite sequencing showed strikingly increased methylation in endometriotic cells compared with endometrial cells (P <.001). A strong correlation between mRNA levels and percentage methylation of the exon II/intron III are observed. Specifically, the Pearson correlation coefficient was.98 (P <.001) for this association. Conclusions: We demonstrated that methylation of a coding exon/intron sequence in the SF-1 gene positively regulated its expression in endometriosis, whereas its hypomethylation in normal endometrium was associated with drastically lower SF-1 levels. © 2011 Society for Gynecologic Investigation.


Liu X.,Central South University | Huang W.,Central South University | Leo S.,Central South University | Li Y.,Central South University | And 2 more authors.
Kidney and Blood Pressure Research | Year: 2014

Background/Aims: There is a strong correlation between non-dipping status and cardiovascular events in chronic kidney disease (CKD) patients. Our study is designed to identify the effect of evening administration of antihypertensive drugs to hypertensive CKD patients. Methods: A comprehensive search of Medline, Embase, the Chinese Biomedical Literature Database, Wanfang Data, Chinese National Knowledge Infrastructure, and the Cochrane Central Register of Controlled Trials was performed in July 2014. Concurrent controlled or crossover trials (including randomized and non-randomized experimental trials) designed to evaluate the effects of evening- versus morning-dosing hypertensive drug regimens on clinical outcomes in CKD patients with hypertension were included. All statistical analyses were performed using the RevMan software, which is available free from the Cochrane Collaboration. Results: Seven trials involving 1277 patients were identified, and the randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs) were classified into two groups. Taking at least one blood pressure-lowering medication at bedtime was not shown to reduce total death (P=0.056) or cardiovascular death (P=0.059) but was shown to reduce total events (P<0.001) and major cardiovascular events (P<0.001) in both RCTs and non-RCTs. Compared with a morning dosing regimen, taking antihypertensive drug in the evening significantly lowered nighttime systolic blood pressure (SBP) (P<0.0001) and diastolic blood pressure (P<0.05) in patients in the RCTs but did not affect blood pressure in patients in the non-RCTs (P<0.05). There is limited evidence from one non-RCT that taking an antihypertensive drug (benazepril 10 mg) in the evening did not increase adverse events (P=0.72) or withdrawals due to adverse events (P=0.64). Conclusions: A regimen of antihypertensive drugs in the evening should be considered for CKD patients with hypertension to lower nighttime blood pressure and help prevent total events and cardiovascular mortality. More studies are needed to verify the results of this study. © 2015 S. Karger AG, Basel.


Qiu Z.,First Hospital of Beijing University | Li T.,First Hospital of Beijing University | Cen X.,First Hospital of Beijing University | Xu W.,First Hospital of Beijing University | Ren H.,First Hospital of Beijing University
Chinese Journal of Clinical Oncology | Year: 2012

Objective: This work aims to investigate the relationship between bcl-2 and VEGF antigen expression and the in situ apoptosis of hematopoietic cells in myelodysplastic syndrome (MDS), and to discuss the pathogenesis of MDS. Methods: Through bone marrow biopsy, the degree of bone marrow hyperplasia, morphological abnormity of hematopoietic cells, and histopathological change, called abnormal localization of immature precursor (ALIP) in light microscopy were observed. Immunohistochemistry was used to monitor the bcl-2 and VEGF antigen expressions. The in situ apoptosis of hematopoietic cells was detected using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method. Results: Different degrees of hematopoietic abnormalities were found in all 13 cases. The two groups with refractory anemia (RA) and refractory anemia with excess of blasts (RAEB) had no significant differences. ALIP was detected in 6 cases, of which 3 were RA (3/8, 37.50%) and the other 3 were RAEB (3/5, 60.00%). Positive VEGF expression was observed in 9 cases, of which 6 were RA (6/8, 750%) and the other 3 were RAEB (3/5, 60.00%). Positive bcl-2 expression was found in 7 cases, including 4 with RA (4/8, 50.00%) and three with RAEB (3/5, 60%). All patients had positive TUNEL results. The patients with ALIP showed higher degrees of in situ apoptosis of hematopoietic cells. Conclusion: MDS patients have various degrees of abnormal apoptosis of hematopoietic cells. The TUNEL method is simple, practical, sensitive, convenient, and specific tool for detecting in situ cell apoptosis. However, the mechanisms in hematopoietic cell apoptosis and clonally malignant proliferation in MDS patients may differ greatly.


Xue Q.,First Hospital of Beijing University | Xu Y.,First Hospital of Beijing University | Yang H.,First Hospital of Beijing University | Zhang L.,First Hospital of Beijing University | And 4 more authors.
Reproductive Sciences | Year: 2014

Steroidogenic factor 1 (SF-1), a transcriptional factor essential for estrogen biosynthesis, is undetectable in endometrial stromal cells and aberrantly expressed in endometriotic stromal cells. Objective: We tried to gain further insight into the mechanism for differential SF-1 expression in endometrial and endometriotic stromal cells. Design: We had previously identified a novel CpG island in SF-1, which is located in the downstream intron 1 region. Here, we evaluated the methylation status of this CpG island. Patients: We obtained the eutopic endometrium from disease-free participants (n = 8) and the walls of cystic endometriosis lesions of the ovaries from another group of participants (n = 8). None of the patients had received any preoperative hormonal therapy. Interventions: Stromal cells were isolated from these 2 types of tissues and subjected to DNA bisulfite treatment and sequence analysis. Results: The SF-1 messenger RNA (mRNA) levels in endometriotic stromal cells were significantly higher than those in endometrial stromal cells. Bisulfite sequencing showed strikingly increased methylation of a 1-kbp region around the previously identified CpG island in endometriotic cells compared with endometrial cells (P <.001). A strong correlation between SF-1 mRNA levels and percentage methylation of the intron 1 region of the SF-1 gene was observed in endometriotic cells (Spearman correlation coefficient,.96; P <.001). Conclusions: Methylation of the intron 1 region of the SF-1 gene is associated with its expression in endometriotic cells. This CpG island therefore plays an important role in regulating SF-1 expression. © 2013 The Author(s).


Wang S.,First Hospital of Beijing University | Zhang X.,First Hospital of Beijing University | Wang Y.,First Hospital of Beijing University | Liu L.-L.,First Hospital of Beijing University | Tu P.,First Hospital of Beijing University
Journal of Clinical Dermatology | Year: 2014

A case of hypereosinophilic syndrome (HES) accompanied with pulmonary embolism(PE) is reported. The primary manifestations were recurrent eruptions on extremities with pruritus and repeated eosinophil count of peripheral blood revealed a high level of eosinophilis(≥ 1 500/μL). Histopathological examination and aspiration biopsy of bone marrow were in accord with hypereosinophilia, the diagnosis of hypereosinophilic syndrome was made. The patient developed an isolated PE in the absence of risk factors, so PE as one of a complication of HES was considered.

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