the First Affiliated Hospital of Peoples Liberation Army General Hospital
the First Affiliated Hospital of Peoples Liberation Army General Hospital
Li C.,Chinese People's Liberation Army |
Li C.,The First Affiliated Hospital Of Peoples Liberation Army General Hospital |
Shi Y.,Chinese People's Liberation Army |
Guo X.,Chinese People's Liberation Army |
And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2017
Objective: To investigate the associations between preoperative and postoperative body mass index (BMI) and disease-free survival (DFS) in patients with gastric cancer. Methods: A total of 434 patients who underwent a curative (R0) resection for gastric cancer between 2011 and 2013 were retrospectively studied. We recorded preoperative BMI, BMI at 1 month after surgery and BMI at 6 months after surgery. All patients were divided into 3 groups according to their BMI: low BMI group (< 18.5 kg/m2), normal BMI group (18.5-25 kg/m2), and high BMI group (≥ 25 kg/m2). Clinical-pathological characteristics, oncologic outcomes, and DFS were collected and compared between the 3 groups. To analyze the effects of changes in BMI from before surgery to 6 months after surgery on DFS, patients were stratified into a stable BMI, increased BMI, and decreased BMI group. DFS was compared between the 3 groups. Results: Regarding preoperative BMI, the 2-year DFS rate was 70.3% in low BMI group, 71.5% in normal BMI group, and 68.8% in high BMI group (P=0.904). No significant differences were observed in DFS according to postoperative BMI. Using changes in BMI to predict DFS, the 2-year DFS rate was 72.2% in the stable BMI group, 91.7% in the increased BMI group, and 64.8% in the decreased BMI group (P=0.149). In a Cox proportional hazards model, a high BMI before surgery, compared to normal BMI, was associated with a lower DFS (hazard ratio 2.64; 95% confidence interval, 1.02-6.84, P=0.045). However, postoperative BMI and BMI change status were also not associated with DFS. Conclusion: Before surgery, normal BMI significantly predicted the higher DFS of patients with gastric cancer compared with the high BMI. However, postoperative BMI and changes in BMI were not independent prognostic factors of DFS. © 2017, E-Century Publishing Corporation. All rights reserved.
Gao F.-Q.,China Japan Friendship Hospital |
Li Z.-J.,Peking University |
Zhang K.,Peking University |
Sun W.,China Japan Friendship Hospital |
Zhang H.,The First Affiliated Hospital Of Peoples Liberation Army General Hospital
Chinese Medical Journal | Year: 2015
Background: Currently, various calculation methods for evaluating blood-loss in patients with total knee arthroplasty (TKA) are applied in clinical practice. However, different methods may yield different results. The purpose of this study was to determine the most reliable method for calculating blood-loss after primary TKA. Methods: We compared blood-loss in 245 patients who underwent primary unilateral TKA from February 2010 to August 2011. We calculated blood-loss using four methods: Gross equation, hemoglobin (Hb) balance, the Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) formula, and Hb-dilution. We determined Pearson’s correlation coefficients for the four methods. Results: There were large differences in the calculated blood-loss obtained by the four methods. In descending order of combined correlation coefficient based on calculated blood-loss, the methods were Hb-balance, OSTHEO formula, Hb-dilution, and Gross equation. Conclusions: The Hb-balance method may be the most reliable method of estimating blood-loss after TKA. © 2015 Chinese Medical Journal.
Luo D.,the First Affiliated Hospital of Peoples Liberation Army General Hospital |
Zhang H.,the First Affiliated Hospital of Peoples Liberation Army General Hospital |
Cheng H.,the First Affiliated Hospital of Peoples Liberation Army General Hospital |
Xiao K.,the First Affiliated Hospital of Peoples Liberation Army General Hospital
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2014
OBJECTIVE: To discuss the early clinical results and risk factors of modified Colonna capsular arthroplasty for young patients with unilateral hip dislocation.METHODS: From July 2011 to February 2013, 25 cases (25 hips) of modified Colonna capsular arthroplasty for unilateral hip dislocation in the 1st affiliated hospital of People's Liberation Army General hospital was collected, including 7 males, 18 females; aged 9.7-25.8 years, averaging 17.8 years; left 12 cases, right 13 cases; Body mass index ranged 15.6-29.6 kg/m², averaging 20.9 kg/m². Clinical indexes were collected, including: range of motion (ROM) of the hip, the Harris Hip Score (HHS), West Ontario and McMaster University Osteoarthritis Index (WOMAC), visual analogue scale (VAS) score before and after surgery, along with the satisfaction score of the surgery, Severin grades, and Tönnis osteoarthritis grades at last follow-up. Paired t-test was applied for the indexes before and after surgery, variances components analysis was applied for the satisfaction score and the function scores at last follow-up compared in 2 groups, aging at surgery <16 years (15 cases) and ≥ 16 years (10 cases).RESULTS: All cases were followed up for 12-18 months, mean 13.4 months. The average hip ROM decreased from 380° in average pre-surgery to 200° in average at last follow-up. Indexes decreased comparing 9 months follow-up to pre-surgery, HHS(78 ± 9 vs. 84 ± 15, t = 2.107, P = 0.046), WOMAC function score(14.8 ± 8.4 vs. 8.6 ± 9.6, t = -2.657, P = 0.014) appeared statistically difference. Indexes increased at the last follow-up, showing no statistically difference. VAS and the satisfaction score were much better in patients <16 years group compared with ≥ 16 years group at last follow-up. VAS was 1.1 ± 0.8 compared with 2.8 ± 1.4 (F = 12.810, P = 0.002), whereas the satisfaction score was 89 ± 17 compared with 66 ± 22 (F = 7.535, P = 0.012). The last radiological follow-up resulted that, Severin grade I 21 cases, grade II 1 case, grade III 2 cases, grade IV 2 cases, and the Tönnis osteoarthritis grade 0 with 5 cases, grade 1 with 12 cases, grade 2 with 7 cases, grade 3 with 1 case.CONCLUSIONS: In this early follow up, the majority of patients who underwent modified Colonna capsular arthroplasty for their unilateral hip dislocation would obtained satisfactory results, but with long term recovery, and the younger group (<16 years) with better clinical results than the elder group ( ≥ 16 years).With strict indications, exacted surgical techniques and optimized rehabilitation, the modified Colonna arthroplasty would have better clinical results.
Hai H.-L.,The First Affiliated Hospital of Peoples Liberation Army General Hospital |
Hai H.-L.,The 98th Hospital of Peoples Liberation Army |
Shen C.-A.,The First Affiliated Hospital of Peoples Liberation Army General Hospital |
Chai J.-K.,The First Affiliated Hospital of Peoples Liberation Army General Hospital |
And 3 more authors.
Chinese Medical Journal | Year: 2013
Background Perforator flaps are used extensively in repairing soft tissue defects. Superior gluteal artery perforator flaps are used for repairing sacral defects, but the tension required for direct closure of the donor area after harvesting of relatively large flaps carries a risk of postoperative dehiscence. This research was to investigate a modified superior gluteal artery perforator flap for repairing sacrococcygeal soft tissue defects. Methods From June 2003 to April 2010, we used our newly designed superior gluteal artery perforator flap for repair of sacrococcygeal soft tissue defects in 10 patients (study group). The wound and donor areas were measured, and the flaps were designed accordingly. Wound healing was assessed over a follow-up period of 6-38 months. From January 1998 to February 2003, twelve patients with sacrococcygeal pressure sores were treated with traditional methods, VY advancement flaps or oblong flaps, as control group. Results After debridement, the soft tissue defects ranged from 12 cm × 10 cm to 26 cm × 22 cm (mean 16.3 cm × 13.5 cm). Four patients were treated using right-sided flaps ranging from 15 cm × 11 cm to 25 cm × 20 cm (mean 18.2 cm × 14 cm). Four patients were treated using left-sided flaps, and two were treated using both right- and left-sided flaps. Suction drains were removed on postoperative Days 3-21 (mean 5.9) and sutures were removed on postoperative Days 12-14. Each flap included 1-2 perforators for each of the donor and recipient sites. Donor sites were closed directly. All flaps survived. In eight patients, the wounds healed after single-stage surgery. After further debridement, the wounds of the remaining two patients were considered healed on postoperative Days 26 and 33, respectively. The rate of first intention in the study group (80%, 8/10) significantly increased than that of control group ((25%, 3/12), χ2=4.583, P=0.032). Follow-up examinations found that the flaps had a soft texture without ulceration. In the two patients without paraplegia, the range of motion of the hip joints was not affected. Conclusion The use of the quadrilobed superior gluteal artery perforator flap can overcome the disadvantages of traditional perforator flaps and represents an improved approach for repairing soft tissue defects in the sacrococcygeal region.
PubMed | the First Affiliated Hospital of Peoples Liberation Army General Hospital
Type: Evaluation Studies | Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2011
To evaluate the efficacy, side effects and toxicity of imatinib mesylate in the treatment of patients with locally advanced and/or metastatic dermatofibrosarcoma protuberans (DFSP).Twenty-four cases of advanced DFSP diagnosed by pathology and treated in our hospital from Nov. 2004 to Oct. 2009 were included in this study. The patients were treated with imatinib mesylate (dosage: 400 mg, po, qd) and carefully observed for treatment efficacy, side effects and survival time. There were 2 patients taking the drug as second line therapy, and other 22 patients as third or more than third line therapy.The 24 patients were evaluable for the efficacy. There were 8 patients (33.3%) with CR, 10 pts (41.7%) PR, 2 patients (8.3%) SD, and 4 patients (16.7%) PD. The disease control rate (DCR = CR+PR+SD) was 83.3%. The median response time in 18 cases with CR and PR was 5.6 months. The median survival time in 20 cases with disease control was 30 months, however, that in nonresponse (PD) cases was only 10 months. Side reactions related to imatinib mesylate included nausea and vomiting (20.8%), neutropenia (12.5%), and edema (8.3%).Our results are consistent with previous reports in the literature. Imatinib is a safe and effective moleucular target drug used for Chinese. Only mild adverse reactions occur in the treated patients. It is worth using imatinib in the treatment of advanced DFSP patients.
PubMed | The First Affiliated Hospital of Peoples Liberation Army General Hospital, University of Shanghai for Science and Technology and Shanghai Academy of Science and Technology
Type: | Journal: Computational and mathematical methods in medicine | Year: 2015
Chromosomal translocation, which generates fusion proteins in blood tumor or solid tumor, is considered as one of the major causes leading to cancer. Recent studies suggested that the disordered fragments in a fusion protein might contribute to its carcinogenicity. Here, we investigated the sequence feature near the breakpoints in the fusion partner genes, the structure features of breakpoints in fusion proteins, and the posttranslational modification preference in the fusion proteins. Results show that the breakpoints in the fusion partner genes have both sequence preference and structural preference. At the sequence level, nucleotide combination AG is preferred before the breakpoint and GG is preferred at the breakpoint. At the structural level, the breakpoints in the fusion proteins prefer to be located in the disordered regions. Further analysis suggests the phosphorylation sites at serine, threonine, and the methylation sites at arginine are enriched in disordered regions of the fusion proteins. Using EML4-ALK as an example, we further explained how the fusion protein leads to the protein disorder and contributes to its carcinogenicity. The sequence and structural features of the fusion proteins may help the scientific community to predict novel breakpoints in fusion genes and better understand the structure and function of fusion proteins.