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Manolea M.M.,University of Medicine and Pharmacy of Craiova | Gavrila O.A.,Filantropia Municipal Hospital | Popescu F.C.,University of Medicine and Pharmacy of Craiova | Novac L.,University of Medicine and Pharmacy of Craiova | Mateescu G.O.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2012

The angiogenesis is a complex process, incompletely understood, regulated by various stimulating and inhibiting angiogenic factors. In the present study, we proposed to evaluate the angiogenic changes that occur in the cases with recurrent pregnancy loss comparing with a control group represented by women with requested abortion. The evaluation of the changes in the vascular bed was made by immunohistochemical methods, evaluating the answer of the curettage products to the mouse anti-human CD31 and CD34 monoclonal antibodies immunolabeling. The endothelial cells reaction to the CD31 antibody was different, very intense in the normal or slightly congestive vessels. The endothelial cells from the strongly congestive vessels had a light and scratchy reaction. We found intense positive reactions in the control group for CD34 in the vessels from the villous axis and also in the vessels from the spongious decidua. In the study group, we found light positive reaction in the vessels from the decidua situated in the proximity of the necrotic areas; we found a light positive reaction also in the vessels and mesenchymal fibroblasts from some chorial villous axis.

Martin A.C.,University of Medicine and Pharmacy of Craiova | Iliescu D.,University of Medicine and Pharmacy of Craiova | Tudorache S.,University of Medicine and Pharmacy of Craiova | Comanescu A.,University of Medicine and Pharmacy of Craiova | And 7 more authors.
Gineco.ro | Year: 2012

Objective. The purpose of our study was to reconsider the complete diagnostic protocol in some selected cases, highly suspected after first trimester anatomical and biochemical evaluation. Method. We used the three-year data from a first trimester morphologic and genetic prospective study conducted in three university clinics. We considered the first trimester (11-14 gestational weeks) morphological and biochemical findings in the affected singleton pregnancies. The diagnostic of the chromosomal abnormalities was made using quantitative fluorescence polymerase chain reaction (QF-PCR) and multiplex ligation-dependent probe amplification (MLPA) techniques after chorionic villous sampling (CVS) and the genetic results were confirmed by karyotyping. Results. In the vast majority of the cases multiple first trimester morphological markers were found in association to chromosomopaties (90.9%). In almost half of the cases (45.4%) more than six anatomical features were found abnormal and also the biochemical risk was increased. In these cases, the genetic techniques were concordant with the ultrasound morphological presumptive diagnosis. In all these patients we noted a high degree of anxiety related to the time needed for completion of genetic assessment. Conclusions. We consider that an alternative approach in certain socio-economic settings is termination of pregnancy (TOP) followed by genetic diagnostic in cases with ultrasound evaluation revealing typical morphological / functional features for genetic syndromes and altered serum biochemistry.

Gavrila A.,Filantropia Municipal Hospital | Novac M.,University of Medicine and Pharmacy of Craiova | Cernea D.,University of Medicine and Pharmacy of Craiova
Gineco.ro | Year: 2012

Hyperhomocysteinemia is due to congenital and acquired changes in the metabolism of homocysteine. During pregnancy, women with MTHFR genetic disorders, which causes a key enzyme in the body to function at lower than normal rate, and hyperhomocysteinemia undergo antepartum anticoagulant treatment with low molecular weight heparin. Complications of pregnancy related to thrombosis and the fact that birth and the onset of labor is unpredictable, lead to unique challenges when it comes to choosing the type of anesthesia. This presentation focuses on the anesthetic implications arising in parturient women affected by thrombophilia.

Carstea D.,Filantropia Municipal Hospital | Georgescu E.F.,Filantropia Municipal Hospital | Gruia C.,University of Medicine and Pharmacy of Craiova | Surlin V.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2013

Early detection of asymptomatic phase or paraneoplastic manifestations in precancerous lesions and an early, correct and accurate diagnosis in terms of pathology of the lesion in question, makes important chances of healing and prolonged patient's life expectations. We present the case of a young patient who came to the emergency room and then admitted in the cardiology department with a heart rhythm disorder. The medical investigations that followed (gastric endoscopy, biopsy, histological and IHC exams), finds gastric polyps, which proved to be gastrointestinal stromal tumors (GIST).

Patrascu A.,University of Medicine and Pharmacy of Craiova | Stanescu M.R.,University of Medicine and Pharmacy of Craiova | Gheorman V.,University of Medicine and Pharmacy of Craiova | Goganau A.M.,University of Medicine and Pharmacy of Craiova | And 4 more authors.
Romanian Journal of Morphology and Embryology | Year: 2013

In this paper, we present the very rare case of a 21 weeks pregnant woman, examined clinically and by ultrasound. We could observe the present of two heads and a common trunk and therefore we proceeded to the small caesarian of necessity. We examined the fetus from the clinical and pathological point of view and we could observe a rare case of pregnancy with a bicephalous malformed fetus. During the autopsy, we could reveal the common elements and the devised ones, which are described as it follows. The case is a very rare one and that probably explains the fact that until the 21 weeks examination, even if she was clinically and ultrasound examined there was the appreciation that it was a twin pregnancy with a normal evolution. In this case, it is necessary to underline that the difficulties concerning the diagnosis and the medical behavior are also because the patient was a primipara 34-year-old woman without any pathological or specific family history. This case analysis shows the necessity of a preconception genetic advice together with the extension of the analysis of the genetic risk in all mothers under 35-year-old, mandatory and supported by the medical system. At the same time, an ultrasound examination of great performance proves to be necessary in order not to prolong the development of a pathological pregnancy.

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