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Harbin, China

Sun X.,Harbin Medical University | Wang L.-m.,Harbin Medical University | Liu Y.-x.,Harbin Medical University | Han S.-t.,Fifth Hospital of Harbin | He Y.,Harbin Medical University
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Virtual reality technology applied research in the field of medicine has achieved fruitful results and shows a good prospect, it is an important tool of digital medical research. OBJECTIVE: To introduce the design and application of computer-based case simulation system with virtual reality technology. METHODS: A computer-based search was performed on CNKI database, VIP database, Wanfang database and EBSCO database for the relate articles from 1991 to 2011 with the key words of "case simulations, CCS, virtual reality" in English and "virtual reality, case simulation" in Chinese. A total of 85 articles were obtained and finally 20 articles were included according to the inclusion criteria. RESULTS AND CONCLUSION: The application of virtual reality technology in the medical field has become more and more wide. The case simulation system designed by virtual reality technology provides the medical workers a new interactive skill training methods. The simulation of the patient's disease status by the interactive computer software is realized, and the clinical course is simulated realistically. And the assessment of the practical skills for the users were achieved, including basic inspection capacity, use and judgment of the high-tech diagnostic techniques, judgment of check results, diagnostic capability, drug treatment capacity, ability to use non-drug treatment and the comprehensive treatment capacity. The virtual simulation system platform has a good prospect in medical education and clinical skills training. Source


Liu X.,Wuhan University of Science and Technology | Liu J.,Wuhan University of Science and Technology | Zhou D.,Fifth Hospital of Harbin | Tang J.,Wuhan University of Science and Technology
2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 | Year: 2010

In this paper, we investigate the classification of masses with texture features. We propose an improved level set method to find the boundary of a mass, based on the initial contour provided by radiologists. After the boundary of a mass is found, texture features from Gray Level Co-occurrence Matrix (GLCM) are extracted from the surrounding area of the boundary of the mass. The extracted texture features are used as the input of Linear discriminant analysis and a support vector machine to classify the mass as benign or malignant. Mammography images from DDSM were used in the experiments and the classification accuracy was evaluated using the area under the receiver operating characteristic (ROC) curve. In the proposed method the area under the ROC curve is Az =0.7. The experimental result shows the effectiveness of the proposed method. © 2010 IEEE. Source


Liu R.,Fifth Hospital of Harbin | Hu X.-H.,Chinese PLA General Hospital | Hu X.-H.,University of Sydney | Wang S.-M.,Heilongjiang University of Chinese Medicine | And 5 more authors.
Burns | Year: 2016

Background To investigate whether pyruvate-enriched oral rehydration solution (Pyr-ORS), compared with citrate-enriched ORS (Cit-ORS), improves hemodynamics and organ function by alleviating vasopermeability and plasma volume loss during intra-gastric fluid rehydration in dogs with severe burn. Methods Forty dogs subjected to severe burn were randomly divided into four groups (n = 10): two oral rehydrated groups with Pyr-ORS and Cit-ORS (group PR and group CR), respectively, according to the Parkland formula during the first 24 h after burns. Other two groups were the intravenous (IV) resuscitation (group VR) with lactated Ringer's solution with the same dosage and no fluid rehydration (group NR). During the next 24 h, all groups received the same IV infusion. The hemodynamics, plasma volume, vasopermeability and water contents and function of various organs were determined. Plasma levels of vascular endothelial growth factor (VEGF) and platelet activating factor (PAF) were detected by ELISA. Results Hemodynamics parameters were significantly improved in group PR superior to group CR after burns. Levels of VEGF and PAF were significantly lower in group PR than in group CR. Organ function parameters were also greatly preserved in group PR, relative to groups CR and NR. Lactic acidosis was fully corrected and survival increased in group PR (50.0%), compared to group CR (20.0%). Conclusion Pyr-ORS was more effective than Cit-ORS in improving hemodynamics, visceral blood perfusion and organ function by alleviating vasopermeability-induced visceral edema and plasma volume loss in dogs with severe burn. © 2016 Elsevier Ltd and ISBI. All rights reserved. Source


Sun B.,University of California at Los Angeles | Taing A.,University of California at Los Angeles | Liu H.,CAS Technical Institute of Physics and Chemistry | Nie G.,Fifth Hospital of Harbin | And 9 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2016

Therapeutic strategies to promote nerve cell growth and improve their functions or stimulate nerve fiber reconnection and ameliorate the loss of neuronal functions are in high demand. A disadvantage of current conventional methods, which includes injection of nerve growth factors (NGF) either systemically or in the affected area, is rapid clearance or degradation of NGF, thereby reducing the effective concentration of NGFs that can reach the damaged nerves to stimulate the healing process. To overcome this obstacle, a nanoparticle platform based on mesoporous silica nanoparticles (MSNs) was developed to not only prevent clearance and degradation of NGFs, but also deliver the NGF directly to nerve cells to promote nerve cell proliferation and neurite growth. We synthesized (NGF)-loaded MSN (MSN-NGF) with a diameter of 65 nm. MSN-NGF significantly promoted the differentiation of neuron-like PC12 cells and growth of neurites compared to NGF alone, as confirmed by MTS cell proliferation assay and optical microscopy analysis. This study shows that MSN-NGF could be an effective therapy to speed up nerve cell growth or recovery of function. © 2016 American Scientific Publishers. All rights reserved. Source


Zhen X.-g.,Fifth Hospital of Harbin | Wang S.-q.,Fifth Hospital of Harbin | Yu Q.,Fifth Hospital of Harbin
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: The ideal drugs therapy for osteolysis may not only relieve the pain, but also save medical costs. OBJECTIVE: To investigate the 5-year effect of alendronate and alfacalcidol combination on preventing periprosthetic osteolysis after total hip arthroplasty. METHODS: Seventy-five patients undergoing cemented total hip replacement after femoral neck fracture were randomly divided into 3 groups: the treatment group was given alendronate and alfacalcidol oral combination therapy, the control group was treated with compound amino acid chelate joint capsule of oral calcium therapy, and the blank control group with normal diet. Periprosthetic bone mineral density and average Harris score were examined at the 1st, 3rd, 5th years after the operation, and imaging evaluation after 5 years. RESULTS AND CONCLUSION: Three and five years after hip replacement, bone density in treatment group was significantly higher than that in the control group (P < 0.05); 5 years after surgery, bone dissolution rate of the treatment group was lower than that of the control group and the blank control group (P < 0.05). The results showed that the combination of alendronate and alfacalcidol played a positive role in preventing the occurrence of osteolysis after hip prosthesis replacement. Source

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