Entity

Time filter

Source Type


Li B.,416 Hospital | Zheng Y.-L.,Chengdu University of Traditional Chinese Medicine | Liu W.-Z.,Fifth Hospital of Chinese PLA
International Journal of Ophthalmology | Year: 2010

• AIM: To observe the influence of the Fritillaria thunbergii's extract on the proliferation of the cultured orbital fibroblasts (OF) of the thyroid-associated ophthalmopathy (TAO)-patients. • METHODS: The cultured OF of the normal and the TAO-patients was introduced. The Fritillaria thunbergii's extract and the Dexamethasone (Dex) as the positive contrast medicine were devided into different groups to detect the influence of the Fritillaria thunbergii's extract on the proliferation of the cultured OF of the normal and the TAO-patients by the MTT method. • RESULTS: The Fritillaria thunbergii's extract showed a similar result to Dex in inhibiting the prolife-ration of cultured OF of the TAO-patients, and both of them showed the dose-dependence. But the inhibition of the Fritillaria thunbergii's extract to the proliferation of the TAO-patients' OF was better than the normal obviously (P < 0.05), and the Dex had no this selectivity. • CONCLUSION: The Fritillaria thunbergii inhibit the proliferation of TAO-patients OF.


Miao X.-D.,Fifth Hospital of Chinese PLA | Pei G.-X.,PLA Fourth Military Medical University | Yan Q.-S.,Fifth Hospital of Chinese PLA | Jia J.,Fifth Hospital of Chinese PLA | Xu Y.,Fifth Hospital of Chinese PLA
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Some experiments have demonstrated that allogenic deproteinized bone combined fibrin glue is more suitable for seed cells growth and proliferation in vitro. OBJECTIVE: To observe the difference between allogenic deproteinized bone combined fibrin glue and allogenic deproteinized bone alone as scaffold materials for bone tissue engineering. METHODS: Twenty-eight New Zealand white rabbits were randomly divided into three groups: allogenic deproteinized bone combined fibrin glue composited with mesenchymal stem cells was implanted in experiment group, allogenic deproteinized bone composited with mesenchymal stem cells implanted in control group, and allogenic deproteinized bone alone implanted in blank group. RESULTS AND CONCLUSION: With the duration of implantation, the alkaline phosphatase activity of eachgroup was increased gradually. The experiment group was higher than control group and blank group in the alkaline phosphatase activity (P < 0.01). New bone tissue formed in both the experiment group and control group at 4 and 8 weeks after implantation, and there were more new bone tissues formed in the experiment group (P < 0.01). In the blank group, there was no new bone formed. Allogenic deproteinized bone combined fibrin glue is more suitable for mesenchymal stem cells than allogenic deproteinized bone alone, and it can be used as a scaffold for bone tissue engineering.

Discover hidden collaborations