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Miyawaki A.,Field of Oral and Maxillofacial Rehabilitation | Hijioka H.,Field of Oral and Maxillofacial Rehabilitation | Ikeda R.,Kagoshima University | Ishida T.,Field of Oral and Maxillofacial Rehabilitation | And 2 more authors.
Oncology Letters | Year: 2012

We introduced concurrent neoadjuvant chemoradiotherapy (CCRT) with S-1, an oral fluoropyrimidine, as treatment for oral squamous cell carcinoma (OSCC) from October 2005. The clinical usefulness and medical safety of CCRT with S-1 (S-1 group) for OSCC were analyzed and compared with CCRT using super-selective intra-arterial infusion (AI group). The subjects in the S-1 group underwent external irradiation, at a total dose of 30 Gy, with S-1 chemotherapy. The AI group received cisplatin (CDDP) or carboplatin (CBDCA) combined with daily radiotherapy at a total dose of 40 Gy. The histological effects and disease-specific survival rates were almost equivalent in the S-1 and AI groups. Adverse events were less frequent in the S-1 group, while hematological toxicity, including anemia, thrombopenia and pharyngeal edema, was observed in the AI group. The results of this study indicate that CCRT combined with S-1 is a more effective and safer treatment for OSCC than AI. Source


Imaizaki T.,Kagoshima University | Nishi Y.,Kagoshima University | Kaji A.,Kagoshima University | Nagaoka E.,Field of Oral and Maxillofacial Rehabilitation
Journal of Prosthodontic Research | Year: 2010

Purpose: This study aimed to clarify the role of the artificial tooth arch (ATA) during swallowing in edentates. Methods: The tongue pressures, activities of the masseter and suprahyoid muscles, and laryngeal and mandibular movements when swallowing saliva, water, pudding, and corned beef were measured simultaneously using experimental dentures with and without an ATA. We analysed the maximum magnitudes of muscle activities and tongue pressures (MAmax and TPmax, respectively), the times from reaching MAmax and TPmax to laryngeal movement (TLM-MAmax and TLM-TPmax, respectively), and the vertical mandibular position. Results: The MAmax of the masseter muscle and TPmax were significantly greater with the ATA than without the ATA (p < 0.05). However, MAmax of the suprahyoid muscles was not significantly different in the conditions with and without the ATA. TLM-TPmax was significantly longer without the ATA than with the ATA (p < 0.05) but the TLM-MAmax of the suprahyoid and masseter muscles were not significantly different with and without the ATA. The MAmax of both suprahyoid and masseter muscles and the TPmax were significantly greater, and TLM-TPmax was significantly longer when swallowing corned beef than other materials (p < 0.05). The intermaxillar distance and the range of measured mandibular position at the time of swallowing were shorter and wider in the absence of the ATA than with it. Conclusion: The present study shows that during swallowing the ATA supports the function of the tongue to perform skillful movements for the smooth passage of food to the oropharynx and the elevation of the larynx by maintaining the mandible position constant near the intercuspal position. © 2009 Japan Prosthodontic Society. Source


Kikuchi K.,Yame Public General Hospital | Uchikado H.,Kurume University | Miyagi N.,Yame Public General Hospital | Kuramoto T.,Omuta City General Hospital | And 10 more authors.
Experimental and Therapeutic Medicine | Year: 2011

Edaravone was originally developed as a potent free radical scavenger and has been widely used to treat cerebral infarction in Japan since 2001. Several free radical scavengers have been developed and some of them have progressed to clinical trials for the treatment of cerebral infarction. One such scavenger, edaravone, has been approved by the regulatory authority in Japan for the treatment of patients with cerebral infarction. Of particular interest is the ability of edaravone to diffuse into the central nervous system in various neurologic diseases. Aside from its hydroxyl radical scavenging effect, edaravone has been found to have beneficial effects on inflammation, matrix metalloproteinases, nitric oxide production and apoptotic cell death. Concordantly, edaravone has been found to have neuroprotective effects in a number of animal models of disease, including stroke, spinal cord injury, traumatic brain injury, neurodegenerative diseases and brain tumors. The proven safety of edaravone following 9 years of use as a free radical scavenger suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans. Source


Miyawaki S.,Kagoshima University | Tomonari H.,Kagoshima University | Yagi T.,Kagoshima University | Kuninori T.,Kagoshima University | And 2 more authors.
American Journal of Orthodontics and Dentofacial Orthopedics | Year: 2015

Introduction Miniscrews are frequently used for skeletal anchorage during edgewise treatment, and their clinical use has been verified. However, their disadvantage is an approximately 15% failure rate, which is primarily attributed to the low mechanical stability between the miniscrew and cortical bone and to the miniscrew's close proximity to the dental root. To solve these problems, we developed a novel spike-like auxiliary skeletal anchorage device for use with a miniscrew to increase its stability. Methods The retention force was compared between miniscrews with and without the auxiliary skeletal anchorage device at each displacement of the miniscrew. The combined unit was also implanted into the bones of 2 rabbits in vivo, and implantation was visually assessed at 4 weeks postoperatively while the compression force was applied. Results The retention force of the combined unit was significantly and approximately 3 to 5 times stronger on average than that of the miniscrew alone at each displacement. The spiked portion of the auxiliary anchorage device embedded into the cortical bone of the hind limb at approximately a 0.3-mm depth at 4 weeks postimplantation in both rabbits. Conclusions The auxiliary skeletal anchorage device may increase miniscrew stability, allow a shortened miniscrew, and enable 3-dimensional absolute anchorage. Further evaluation of its clinical application is necessary. © 2015 American Association of Orthodontists. Source


Hijioka H.,Field of Oral and Maxillofacial Rehabilitation | Nishihara K.,The University of Okinawa | Suzuki H.,Field of Oral and Maxillofacial Rehabilitation | Ishida T.,Field of Oral and Maxillofacial Rehabilitation | And 5 more authors.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | Year: 2015

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare odontogenic malignant tumor, and the origin is considered remnant odontogenic epithelium, odontogenic cyst, and rarely benign odontogenic tumors. We report an extremely rare case of PIOSCC arising from ameloblastoma. A 62-year-old man complained a large hard mass at the sublingual to the submental region. The computed tomography images revealed a large multilocular soft tissue mass extending into the bilateral molar areas with expansion of the mandible and also into the subcutaneous layer at the submental and the submandibular regions. He had received a curettage treatment of unicystic ameloblastoma in the right mandible 23 years ago. Malignant odontogenic tumor was suspected, and sectional mandibulectomy following reconstruction using a titanium plate and pedicle latissimus dorsi flap were performed. Histological examination disclosed a close correlation of intraosseous growth of squamous cell carcinoma and ameloblastoma. PIOSCC arising and dedifferentiated from long term existed ameloblastoma was mostly considered. There has been no recurrence and no metastasis for more than five years after the surgical treatment. © 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Source

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