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Filothei, Greece

Manche A.,FETCS
Malta Medical Journal | Year: 2013

Objectives: To evaluate the early outcomes after coronary surgery in the elderly. Methods: A retrospective analysis (April 1995-January 2012) of mortality, morbidity and hospital stay, derived from a single surgeon's practice. Outcomes of patients over 70 (group A, n=785) were compared with those of controls under 70 (group B, n=2772). Results: Intervention rate was significantly higher (1502/106 vs 467/106, p<0.0001). There were significantly fewer single and quintuple grafts, and significantly more double grafts in group A. The use of an internal thoracic artery (ITA) was lower in group A (748/785, 95.3% vs 2695/2772, 97.2%, p=0.006). Mortality for the entire coronary surgical practice was 1.2%. The overall mortality was 2.7% in group A and 0.8% in group B (p<0.0001). Freedom from any post operative complication occurred in 57.7% in group A and in 75.6% in group B (p<0.0001). Cardiac complications (except for perioperative MI and a trial flutter) were significantly higher in group A, as were major neurological, renal and respiratory complications, as well as minor wound complications. All complications resulted in patient morbidity but cerebrovascular accident had the worst impact, contributing to perioperative death in 8 of the 18 cases in group A and in 4 of the 24 cases in group B (p=0.049). Average length of stay on intensive care was similar (1.19±1.84 days for group A and 1.13±1.48 days for group B, p=0.38). The average HDU stay was longer in group A (1.43±2.70 vs 0.95±3.68 days, p=0.006) as was the average ward stay (4.00±3.33 vs 3.25±2.23 days, p<0.0001). Conclusions: Although mortality and morbidity remain significantly higher, taken in the context of the overall clinical problem, cardiac surgery has much to offer in this select group of patients. Source

Agathos E.A.,FETCS | Agathos E.A.,Perouse Medical Shanghai Co | Agathos E.A.,National and Kapodistrian University of Athens | Shen M.,FETCS | And 14 more authors.
ASAIO Journal | Year: 2012

Biological valves offer significant advantages over mechanical valves, and for this reason, we studied the possibility of using a new animal source such as that of Phoca groenlandica. Four aortic and four pulmonary leaflets were cut radially and their uniaxial tensile testing was evaluated. Three prototype pulmonary valves of Phoca groenlandica preserved in buffered glutaraldehyde solution 0.625% at pH 7.4 were mounted on a 19, 21, and 27 mm novel support system (stent) with heart shape commissural posts covered with polytetrafluoroethylene. The valves were tested in a steady flow system, the peak pressure gradients (PPGs) were measured, and the effective orifice areas (EOAs) were calculated for the flows of 3, 4, 5, 6, and 8 L/min. There were five different measurements for each flow variant. Aortic and pulmonary leaflets present no statistically significant difference in failure strength (p = 0.93). The PPGs across the valves for the flow of 3, 4, 5, 6, and 8 L/min for all three tested valves were low and the corresponding calculated EOAs were large. The new bioprosthetic valve derived from the pulmonary valve of Phoca groenlandica mounted on this novel support system presented a satisfactory hydrodynamic performance in a steady flow system. More research is needed before it can be considered suitable for human cardiac valve replacement. Copyright © 2012 by the American Society for Artificial Internal. Source

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