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Vezzetti E.,Polytechnic University of Turin | Tornincasa S.,Polytechnic University of Turin | Marcolin F.,Polytechnic University of Turin | Moos S.,Polytechnic University of Turin | And 4 more authors.
Proceedings of the 12th IASTED International Conference on Biomedical Engineering, BioMed 2016 | Year: 2016

A 3D automatic facial expression recognition procedure is presented in this work. The method is based on point-by-point mapping of seventeen Differential Geometry descriptors onto the probe facial depth map, which is then partitioned into seventy-nine regions. Then, features such as mean, median, mode, volumes, histograms are computed for each region and for each descriptor, to reach a varied large set of parameters representing the query face. Each set of parameters, given by a geometrical descriptor, a region, and a feature, form a trio, whose featuring numerical values are compared with appropriate thresholds, set via experimentation in a previous phase by processing a limited portion of the public facial Bosphorus database. This allows the identification of the emotion-based expression of the query 3D face among the six basic ones (anger, disgust, fear, joy, sadness, surprise). The algorithm was tested on the Bosphorus database and is suitable for applications in security, marketing, medical. The three-dimensional context has been preferred due to its invariance to different lightening/make-up/camouflage conditions.


Cignini P.,Fetal Maternal Medical Center | Giorlandino M.,Fetal Maternal Medical Center | Brutti P.,University of Rome La Sapienza | Mangiafico L.,Fetal Maternal Medical Center | And 2 more authors.
PLoS ONE | Year: 2016

Objective To establish reference charts for fetal cerebellar vermis height in an unselected population. Methods A prospective cross-sectional study between September 2009 and December 2014 was carried out at ALTAMEDICA Fetalâ€"Maternal Medical Centre, Rome, Italy. Of 25203 fetal biometric measurements, 12167 (48%) measurements of the cerebellar vermis were available. After excluding 1562 (12.8%) measurements, a total of 10605 (87.2%) fetuses were considered and analyzed once only. Parametric and nonparametric quantile regression models were used for the statistical analysis. In order to evaluate the robustness of the proposed reference charts regarding various distributional assumptions on the ultrasound measurements at hand, we compared the gestational age-specific reference curves we produced through the statistical methods used. Normal mean height based on parametric and nonparametric methods were defined for each week of gestation and the regression equation expressing the height of the cerebellar vermis as a function of gestational age was calculated. Finally the correlation between dimension/gestation was measured. Results The mean height of the cerebellar vermis was 12.7mm (SD, 1.6mm; 95% confidence interval, 12.7â€"12.8mm). The regression equation expressing the height of the CV as a function of the gestational age was: height (mm) = -4.85+0.78 x gestational age. The correlation between dimension/gestation was expressed by the coefficient r = 0.87. Conclusion This is the first prospective cross-sectional study on fetal cerebellar vermis biometry with such a large sample size reported in literature. It is a detailed statistical survey and contains new centile-based reference charts for fetal height of cerebellar vermis measurements. © 2016 Cignini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Padula F.,Fetal Maternal Medical Center | Gulino F.A.,University of Catania | Capriglione S.,Biomedical University of Rome | Giorlandino M.,Fetal Maternal Medical Center | And 4 more authors.
Journal of Ultrasound in Medicine | Year: 2015

Objectives-The purpose of this study was to estimate the rate of incomplete fetal anatomic surveys during a second-trimester scan due to an unfavorable fetal position in a nonobese population. Methods-All pregnant women who came to the Altamedica Fetal-Maternal Medical Center, a specialized center for prenatal diagnosis, for a routine second-trimester scan between January 2012 and April 2013 were retrospectively included in the analysis. Patients with a body mass index higher than 30.0 kg/m2 or anterior fibroids larger than 5 cm were not included in the study. Results-Of 4000 pregnant women admitted for a second-trimester scan, 169 (4.2%) came back within 2 weeks to complete the examination because of an unfavorable fetal position. In particular, 104 (2.6%) needed visualization of only 1 view, and 65 (1.6%) needed more than 1 view. The most difficult organ to visualize was the corpus callosum, in 73 cases (1.8%); the face was not visualized in 69 cases (1.7%); the cerebellar vermis was not seen in 47 fetuses (1.1%); and the heart could not be completely examined in 40 fetuses (1.0%). Of the 4000 women, 169 (4.2%) had a nonexhaustive scan; 149 (3.7%) needed a second scan to complete the second-trimester survey; 14 (0.35%) needed a third scan; and 2 (0.05%) remained with a not completely exhaustive scan. Conclusions-There is always a small percentage of incomplete fetal anatomic surveys during a second-trimester scan, which cannot be modified by the sonographer's skill or by technical sonographic innovations. ©2015 by the American Institute of Ultrasound in Medicine.


PubMed | University of Rome La Sapienza, Biomedical University of Rome and Fetal Maternal Medical Center
Type: Journal Article | Journal: PloS one | Year: 2016

To establish reference charts for fetal cerebellar vermis height in an unselected population.A prospective cross-sectional study between September 2009 and December 2014 was carried out at ALTAMEDICA Fetal-Maternal Medical Centre, Rome, Italy. Of 25203 fetal biometric measurements, 12167 (48%) measurements of the cerebellar vermis were available. After excluding 1562 (12.8%) measurements, a total of 10605 (87.2%) fetuses were considered and analyzed once only. Parametric and nonparametric quantile regression models were used for the statistical analysis. In order to evaluate the robustness of the proposed reference charts regarding various distributional assumptions on the ultrasound measurements at hand, we compared the gestational age-specific reference curves we produced through the statistical methods used. Normal mean height based on parametric and nonparametric methods were defined for each week of gestation and the regression equation expressing the height of the cerebellar vermis as a function of gestational age was calculated. Finally the correlation between dimension/gestation was measured.The mean height of the cerebellar vermis was 12.7mm (SD, 1.6mm; 95% confidence interval, 12.7-12.8mm). The regression equation expressing the height of the CV as a function of the gestational age was: height (mm) = -4.85+0.78 x gestational age. The correlation between dimension/gestation was expressed by the coefficient r = 0.87.This is the first prospective cross-sectional study on fetal cerebellar vermis biometry with such a large sample size reported in literature. It is a detailed statistical survey and contains new centile-based reference charts for fetal height of cerebellar vermis measurements.


PubMed | University of Catania, Messina University, Biomedical University of Rome and Fetal Maternal Medical Center
Type: Journal Article | Journal: Facts, views & vision in ObGyn | Year: 2016

To evaluate the accuracy of ultrasound in visualizing placental cord insertion (PCI) at different gestational ages in order to recommend the most feasible period during pregnancy to identify it. Secondary aim was to propose a predictive algorithm for PCI visualization.We performed a single-center, prospective cohort study. We enrolled patients with singleton low-risk pregnancies who underwent fetal ultrasound scan at different gestational ages. We excluded patients with body mass index of 30 Kg/m2 or more, uterine fibroids larger than 5 cm, high-risk pregnancies, fetal weight lower than < 10 percentile or higher than > 90 percentile, increased (deep pocket > 80 mm) or decreased (deep pocket < 20 mm) amniotic fluid.Among the 468 recruited patients, the visualization of PCI was not possible in 5.77% of the cases. Furthermore, we showed that PCI visualization was lower as the gestational age increased (p = 0.049) and more difficult in case of posterior placenta (p = 0.001).PCI should be evaluated in the first trimester or as early as possible during the second trimester. Moreover, we propose a feasible model to predict the possibility of PCI visualization according to gestational age and uterine site of implantation.


Moos S.,Polytechnic University of Turin | Marcolin F.,Polytechnic University of Turin | Tornincasa S.,Polytechnic University of Turin | Vezzetti E.,Polytechnic University of Turin | And 4 more authors.
International Journal on Interactive Design and Manufacturing | Year: 2014

This work proposes a methodology to automatically diagnose and formalize prenatal cleft lip with representative key points and identify the type of defect (unilateral, bilateral, right, or left) in three-dimensional ultrasonography (3D US). Differential Geometry has been used as a framework for describing facial shapes and curvatures. Then, descriptors coming from this field are employed for identifying the typical key points of the defect and its dimensions. The descriptive accurateness of these descriptors has allowed us to automatically extract reference points, quantitative distances, labial profiles, and to provide information about facial asymmetry. Seventeen foetal faces, nine of healthy foetuses and eight with different types of cleft lips, have been obtained through a Voluson system and used for testing the algorithm. In case no defect is present, the algorithm detects thirteen standard facial soft-tissue landmarks. This would help ultrasonographists and future mothers in identifying the most salient points of the forthcoming baby. This algorithm has been designed to support practitioners in identifying and classifying cleft lips. The gained results have shown that differential geometry may be a valuable tool for describing faces and for diagnosis. © 2014 Springer-Verlag France


Vitale S.G.,University of Catania | Padula F.,Fetal Maternal Medical Center | Gulino F.A.,University of Catania
Current Opinion in Obstetrics and Gynecology | Year: 2015

Purpose of review The review analyzes how fibroids may influence pregnancy and how myomas may be modified by pregnancy. The most important clinical aspect concerns the impact of myoma on pregnancy and the possibility of a well tolerated surgical treatment for the mother and her fetus, preserving maternal reproductive capacity. Recent findings Fibroids significantly increase in size during early pregnancy and then decrease in the third trimester. Although most women with uterine fibroids have a regular pregnancy, data from the literature suggest that they may have a higher risk of fertility problems and pregnancy complications. Summary Myomectomy can increase the rate of pregnancy in women with infertility, attempting to restore a normal anatomy and reduce uterine contractility and local inflammation associated with the presence of fibroids, improving the blood supply. Current evidence does not suggest routine myomectomy during pregnancy or at the cesarean birth, as fibroids-related complications are rare and may be overcome by the risks of surgery. However, in selected cases, myomectomy is a feasible and safe technique and associated to a good outcome. The diagnosis of myomas in pregnancy may require attention for the adequate management to preserve maternal and fetal well-being. © 2015 Wolters Kluwer Health, Inc. All rights reserved.


PubMed | Fetal Maternal Medical Center
Type: Journal Article | Journal: Journal of prenatal medicine | Year: 2012

Small supernumerary marker chromosomes (sSMCs) have been described from all human chromosomes with different sizes and shapes. However, it is difficult to know the clinical manifestations associated with them, because such knowledge depends on the size, presence of euchromatic material, degree of mosaicism and/or uniparental disomy (UPD).A case report of a familial small supernumerary marker chromosome (sSMC) through a structural and a segregation study is reported.


PubMed | Fetal Maternal Medical Center
Type: Journal Article | Journal: Journal of prenatal medicine | Year: 2012

Pelvic dilatation is the alteration of the urinary tractmost frequently detected by maternal-fetalultra-sound. Hydronephrosis is not a diagnosis; it is an imagefinding. The diagnosis is the cause that produces it. Since pelvic dilatation is relatively frequent in thenormal fetus, and the definition and diagnosis of hy-dronephrosis are difficult, once it is detected, adequate follow-up is required. Therefore, it is important for the urologist and obstetrician to understanddifferential diagnosis and clinical implications in order to offer an accurate counselling to the parents.

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